All hotels in Southern Illinois, Illinois
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
All hotels in Southern Illinois, Illinois
We have found 1042 Southern Illinois Hotels
- Drury Plaza Hotel Mt. Vernon
- Red Lion Inn & Suites Pontoon Beach
- Drury Inn & Suites Marion
- Drury Inn & Suites St. Louis Fairview Heights
- Days Inn & Suites by Wyndham Caseyville
- La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis
- Super 8 by Wyndham Fairview Heights-St. Louis
- Baymont by Wyndham Marion
- La Quinta Inn & Suites by Wyndham Effingham
- Radisson Hotel Fairview Heights - St. Louis
- Comfort Suites Fairview Heights
- Comfort Suites Mount Vernon
- Drury Inn & Suites St. Louis O'Fallon, IL
- Super 8 by Wyndham Troy IL/St. Louis Area
- Baymont by Wyndham O'Fallon St. Louis Area
- DoubleTree by Hilton Collinsville - St. Louis
- Ramada by Wyndham Effingham
- Days Inn by Wyndham Troy IL
- Holiday Inn Express & Suites Edwardsville by IHG
- Days Inn by Wyndham Mount Vernon
- Americas Best Value Inn Collinsville St. Louis
- La Quinta Inn & Suites by Wyndham Collinsville - St. Louis
- Country View Inn & Suites
- Baymont by Wyndham Chester IL
- The Principal Hotel
- Baymont by Wyndham Effingham
- Econo Lodge Inn & Suites
- Quality Inn & Suites Vandalia near I-70 and Hwy 51
- Walker's Bluff Casino Resort
- DoubleTree by Hilton Mt. Vernon
- Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
- Super 8 by Wyndham Carbondale
- Holiday Inn Effingham by IHG
- Seasons Inn & Suites Highland
- Holiday Inn Carbondale-Conference Center by IHG
- Ramada by Wyndham Vandalia
- Holiday Inn Express Metropolis by IHG
- Super 8 by Wyndham Mt. Vernon IL
- Holiday Inn Express & Suites Mount Vernon by IHG
- Holiday Inn St. Louis Fairview Heights by IHG
- Harrah's Metropolis Hotel & Casino
- Fairfield Inn & Suites by Marriott O'Fallon, IL
- Best Western St. Louis Fairview Heights
- Super 8 by Wyndham Grayville
- Holiday Inn Express & Suites Mattoon by IHG
- Holiday Inn Express & Suites - O'Fallon /Shiloh by IHG
Let Expedia take you to the best Hotels in Southern Illinois. You'll find the largest selection of hotel deals, discount prices, and cheap hotel rates on reservations anywhere in the world. Expedia, the leader in world travel, gives you customer reviews, maps, and the best selection of hotels near landmarks and attractions.