Upstate South Carolina 4 Stars Hotels

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Upstate South Carolina 4 Star Hotels

Our top choices for Upstate South Carolina 4-star hotels

Exterior

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
4.0 star property
Greenville Downtown
9.6 out of 10, Exceptional, (491 reviews)
"Lovely hotel"
United States
Shelley
The price is P21,492
P24,286 total
includes taxes & fees
Jun 7 - Jun 8
Grand Bohemian Lodge Greenville, Autograph Collection
Lobby

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
Clemson
9.8 out of 10, Exceptional, (797 reviews)
"Great location great restaurant"
United States
Jennifer
The price is P10,213
P11,337 total
includes taxes & fees
May 17 - May 18
The Shepherd Hotel Downtown Clemson
Restaurant

Hotel Hartness

Hotel Hartness
4.0 star property
Greenville
9.8 out of 10, Exceptional, (718 reviews)
"One of my favorite hotels, lovely facility and great staff."
United States
Sara
The price is P10,393
P13,511 total
includes taxes & fees
Jun 1 - Jun 2
Hotel Hartness
Living area

Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (826 reviews)
"Great spot"
United States
david
The price is P6,300
P6,930 total
includes taxes & fees
May 31 - Jun 1
Mint House Greenville Downtown by Kasa
Premium bedding, down comforters, pillowtop beds, in-room safe

Greenville Marriott

Greenville Marriott
4.0 star property
Greenville
8.6 out of 10, Excellent, (651 reviews)
"Awesome stay. Staff was super nice"
United States
Joshua
The price is P7,860
P8,931 total
includes taxes & fees
May 31 - Jun 1
Greenville Marriott
In-room safe, desk, blackout drapes, iron/ironing board

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (598 reviews)
"Easy parking, great location. Will stay there again"
United States
William
The price is P8,787
P9,754 total
includes taxes & fees
May 17 - May 18
The Abernathy of Clemson
Exterior

The Westin Poinsett Greenville

The Westin Poinsett Greenville
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (1,000 reviews)
"Beautiful hotel, perfect location for walking downtown Greenville! Easy parking in attached garage, friendly staff!"
United States
Mary
The price is P11,606
P12,951 total
includes taxes & fees
May 25 - May 26
The Westin Poinsett Greenville
Front of property

Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
4.0 star property
Pendleton
10.0 out of 10, Exceptional, (88 reviews)
"The was by far one of the best bed and breakfast places that I have ever stayed in. The house is beautiful, the rooms and spotless and the breakfast is amazing. "
United States
Jennifer Ann
The price is P9,654
P10,716 total
includes taxes & fees
May 28 - May 29
Liberty Hall Bed and Breakfast
Terrace/patio

The Station by Compo Hotels

The Station by Compo Hotels
4.0 star property
Travelers Rest
10.0 out of 10, Exceptional, (19 reviews)
"Swamp rabbit trail and restaurants very close "
United States
Martin
The price is P15,190
P21,775 total
includes taxes & fees
May 18 - May 19
The Station by Compo Hotels
Courtyard

Hotel Domestique

Hotel Domestique
4.0 star property
Travelers Rest
9.8 out of 10, Exceptional, (33 reviews)
"Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away."
United States
Chuck
The price is P25,115
P27,627 total
includes taxes & fees
May 18 - May 19
Hotel Domestique
Lobby

Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek
4.0 star property
Greer
Landing Apartments Greer - Sugar Creek
Front of property

Tee Times & Lake Days! Luxe Keowee Key Living

Tee Times & Lake Days! Luxe Keowee Key Living
4.0 star property
Salem
Tee Times & Lake Days! Luxe Keowee Key Living
Interior

Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
4.0 star property
Salem
10.0 out of 10, Exceptional, (1 review)
"Property is in a great community, and it was very clean and beautifully decorated."
United States
Anonymous traveler
Designer Retreat w/ Pool, Golf + Beach Access!
Individually decorated, individually furnished, desk, laptop workspace

Landing Furnished Apartments - Spartanburg, SC

Landing Furnished Apartments - Spartanburg, SC
4.0 star property
Spartanburg
Landing Furnished Apartments - Spartanburg, SC
Interior

Private Balcony: Lake Keowee Home w/ Pool Access

Private Balcony: Lake Keowee Home w/ Pool Access
4.0 star property
Salem
Private Balcony: Lake Keowee Home w/ Pool Access
Interior

Keowee Key Condo w/ Lake Access & Community Pools!

Keowee Key Condo w/ Lake Access & Community Pools!
4.0 star property
Salem
Keowee Key Condo w/ Lake Access & Community Pools!
Front of property

Views, Pools & Marina: Lake Keowee Condo!

Views, Pools & Marina: Lake Keowee Condo!
4.0 star property
Salem
Views, Pools & Marina: Lake Keowee Condo!
Interior

Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!
4.0 star property
Salem
Salem Vacation Rental w/ Lake Keowee Access!
Interior

5 Mi to Memorial Stadium & Beach: Modern Townhome

5 Mi to Memorial Stadium & Beach: Modern Townhome
4.0 star property
Central
5 Mi to Memorial Stadium & Beach: Modern Townhome
Private kitchen

Park Place Apartments by Landing

Park Place Apartments by Landing
4.0 star property
Greenville
7.6 out of 10, Good, (46 reviews)
"Loved the apartment! Very spacious, clean, brand new. Access to bike paths. Seemed like a quirky location but everything is close by car or bike. "
United States
Kathie
Park Place Apartments by Landing
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina
Photo by Visit Greenville, South Carolina
Open Photo by Visit Greenville, South Carolina

Top Upstate South Carolina Hotel Reviews

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

10/10 Excellent
"The hotel is centrally located- the staff is attentive, they love my dog!!! The place is clean and the outdoor bar is lovely. Would definitely recommend-"
Marc 1-night trip
Posted 6 days ago
Grand Bohemian Lodge Greenville, Autograph Collection

Frequently asked questions

What are the best 4-star hotels in Upstate South Carolina?
Stay at Greenville Marriott and get ready for upscale comfort and plenty of handy amenities. This 4-star hotel in Greer, Upstate South Carolina, is highly recommended by Expedia guests.
How much does it cost to stay in a 4-star hotel in Upstate South Carolina?
Expedia can help you quickly locate the perfect 4-star hotel for your getaway in Upstate South Carolina. Use our handy filter tool to tailor your search by things like amenities, budget and property star rating and get access to fabulous deals in a few clicks.

  • Search for the lowest price from P6,930

What's the difference between 5-star and 4-star hotels in Upstate South Carolina?
Offering a friendly guest experience and upmarket décor, 4-star hotels are a wonderful option for your Upstate South Carolina trip. These kinds of accommodations generally come with loads of handy amenities that make it simple to kick back and relax — think large beds, bathrobes, restaurants and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. Full-service health clubs, premium toiletries and fine dining are typically featured at these deluxe retreats.

Explore a world of travel with Expedia