Photo by Michelle Hendrix

Upstate South Carolina 4 Stars Hotels

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Check availability on Upstate South Carolina 4 Star Hotels

Tonight
Dec 28 - Dec 29
Tomorrow
Dec 29 - Dec 30
Next weekend
Jan 2 - Jan 4
In two weeks
Jan 9 - Jan 11

Our top choices for Upstate South Carolina 4-star hotels

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Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
4.0 star property
Greenville Downtown
9.6 out of 10, Exceptional, (424)
"Absolutely one of the best hotels to stay at. "
United States
stephen
The price is P18,447
P20,845 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Grand Bohemian Lodge Greenville, Autograph Collection
Meeting facility
The Westin Poinsett Greenville

The Westin Poinsett Greenville

The Westin Poinsett Greenville
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (1004)
"Great historic hotel. Great location and awesome staff."
United States
John
The price is P10,516
P11,567 total
includes taxes & fees
Jan 11 - Jan 12, 2026
The Westin Poinsett Greenville
In-room safe, blackout drapes, soundproofing, iron/ironing board
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
Clemson
9.8 out of 10, Exceptional, (745)
"Staff was amazing and our room was clean and comfortable. "
United States
Amanda R
The price is P9,928
P11,020 total
includes taxes & fees
Dec 30 - Dec 31
The Shepherd Hotel Downtown Clemson
Restaurant
Hotel Hartness

Hotel Hartness

Hotel Hartness
4.0 star property
Greenville
9.8 out of 10, Exceptional, (633)
"The hotel was clean staff was amazing room was outstanding."
United States
Clifford
The price is P8,891
P11,764 total
includes taxes & fees
Dec 30 - Dec 31
Hotel Hartness
Premium bedding, down comforters, pillowtop beds, in-room safe
Greenville Marriott

Greenville Marriott

Greenville Marriott
4.0 star property
Greenville
8.6 out of 10, Excellent, (612)
"Bed was SO comfortable, I slept all through the night!!! Staff incredible especially the girls at breakfast and Adam at the bar. "
United States
LYNNE
The price is P6,168
P6,785 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Greenville Marriott
Laptop workspace, iron/ironing board, free WiFi, bed sheets
Mint House Greenville - Downtown

Mint House Greenville - Downtown

Mint House Greenville - Downtown
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (781)
"Spotless wonderful stay"
United States
Tanganica
Mint House Greenville - Downtown
Meeting facility
The Abernathy of Clemson

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (558)
"location is amazing! "
United States
colleen
The Abernathy of Clemson
Living area
Park Place Apartments by Landing

Park Place Apartments by Landing

Park Place Apartments by Landing
4.0 star property
Greenville
7.6 out of 10, Good, (44)
"Loved the apartment! Very spacious, clean, brand new. Access to bike paths. Seemed like a quirky location but everything is close by car or bike. "
United States
Kathie
Park Place Apartments by Landing
Terrace/patio
The Station by Compo Hotels

The Station by Compo Hotels

The Station by Compo Hotels
4.0 star property
Travelers Rest
10.0 out of 10, Exceptional, (15)
"great place perfect for more privacy vs. a standard hotel"
United States
John
The price is P10,522
P16,420 total
includes taxes & fees
Jan 5 - Jan 6, 2026
The Station by Compo Hotels
Bar (on property)
Hotel Domestique

Hotel Domestique

Hotel Domestique
4.0 star property
Travelers Rest
9.8 out of 10, Exceptional, (31)
"Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away."
United States
Chuck
The price is P16,155
P17,771 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Hotel Domestique
Restaurant
Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
4.0 star property
Pendleton
10.0 out of 10, Exceptional, (78)
"The owners are amazing. Comfy rooms, stellar breakfast and good people. "
United States
Renee
The price is P7,389
P11,139 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Liberty Hall Bed and Breakfast
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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina
The view from Caesars Head after a storm
Photo by Michelle Hendrix
Open Photo by Michelle Hendrix

Top Upstate South Carolina Hotel Reviews

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

10/10 Excellent
"It was a lovely hotel and we enjoyed our stay!"
Joel 1-night trip
Posted 4 days ago
Grand Bohemian Lodge Greenville, Autograph Collection
The Westin Poinsett Greenville

The Westin Poinsett Greenville

10/10 Excellent
"Great historic hotel. Great location and awesome staff."
John 2-night trip
Posted 6 days ago
The Westin Poinsett Greenville

Frequently asked questions

What are the best 4-star hotels in Upstate South Carolina?
Stay at Greenville Marriott and get ready for upscale comfort and plenty of handy amenities. This 4-star hotel in Greer, Upstate South Carolina, is highly recommended by Expedia guests.
How much does it cost to stay in a 4-star hotel in Upstate South Carolina?
Expedia can help you quickly locate the perfect 4-star hotel for your getaway in Upstate South Carolina. Use our handy filter tool to tailor your search by things like amenities, budget and property star rating and get access to fabulous deals in a few clicks.

  • Search for the lowest price from P6,785

What's the difference between 5-star and 4-star hotels in Upstate South Carolina?
Offering a friendly guest experience and upmarket décor, 4-star hotels are a wonderful option for your Upstate South Carolina trip. These kinds of accommodations generally come with loads of handy amenities that make it simple to kick back and relax — think large beds, bathrobes, restaurants and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. Full-service health clubs, premium toiletries and fine dining are typically featured at these deluxe retreats.

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