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Our top choices for Upstate South Carolina hotels

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Hampton Inn & Suites Clinton - I-26

Clinton

Bobby

P8,138 total

includes taxes & fees

Jul 29 - Jul 30

Best Western Spartanburg I-26

Spartanburg

Daniel

P5,950 total

includes taxes & fees

Jul 17 - Jul 18

The Inn at Patrick Square

Clemson

Karyn

P10,177 total

includes taxes & fees

Jul 12 - Jul 13

Holiday Inn Express Gaffney by IHG

Gaffney

melvin

P6,134 total

includes taxes & fees

Aug 2 - Aug 3

Best Western Plus Clemson Hotel & Conference Center

Clemson

Tammy

P6,502 total

includes taxes & fees

Jul 15 - Jul 16

Hampton Inn Greer Greenville, SC

Greer

Trina

P9,323 total

includes taxes & fees

Jul 12 - Jul 13

Clemson University's James F. Martin Inn

Clemson

Jesse

P9,835 total

includes taxes & fees

Jul 12 - Jul 13

Deluxe Inn

Mauldin

Diane

P4,569 total

includes taxes & fees

Jul 12 - Jul 13

Egyptian cotton sheets, premium bedding, pillowtop beds, in-room safe

Days Inn by Wyndham Greenville South/Mauldin

Mauldin

Scott

P4,776 total

includes taxes & fees

Jul 26 - Jul 27

Microtel Inn & Suites by Wyndham Anderson/Clemson

Anderson

Kathryn A

P5,748 total

includes taxes & fees

Jul 14 - Jul 15

Hampton Inn Anderson/ Alliance Business Park

Anderson

Kelly

P7,754 total

includes taxes & fees

Aug 1 - Aug 2

Clarion Greenville Airport Inn

Greenville

Gladys

P4,718 total

includes taxes & fees

Aug 1 - Aug 2

Premium bedding, individually decorated, desk, laptop workspace

Comfort Inn & Suites Clemson - University Area

Clemson

Lon

P7,489 total

includes taxes & fees

Aug 9 - Aug 10

Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

Spartanburg

Thomas

P5,622 total

includes taxes & fees

Jul 26 - Jul 27

Best Western Plus Greenville I-385 Inn & Suites

Greenville

Shabana

P5,577 total

includes taxes & fees

Jul 19 - Jul 20

Quality Inn Clinton - Laurens I-26

Clinton

"We were there for a quick overnight stay and I would say it was a good experience for a very good price. We needed a pet friendly place and the room rate + the pet fee was still very reasonable. The property is older, but VERY clean and the bed was comfortable. The lady who checked us in and the gentleman who checked us out the next morning were both very nice. The complimentary breakfast was good. We would stay here again. I will add that we did not use the pool, but that area is very...

Emily

P4,535 total

includes taxes & fees

Aug 1 - Aug 2

Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Janet

P7,410 total

includes taxes & fees

Aug 2 - Aug 3

Comfort Inn & Suites Greer - Greenville

Greer

David

P7,319 total

includes taxes & fees

Aug 9 - Aug 10

Days Inn by Wyndham Anderson

Anderson

Eli

P4,006 total

includes taxes & fees

Jul 27 - Jul 28

Best Western Spartanburg Northwest

Spartanburg

Shatima

P5,796 total

includes taxes & fees

Jul 19 - Jul 20

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Vacation Rentals in Upstate South Carolina

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Awesome place "

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Apartment

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Great deal for the location. Apartment needed a little bit of love/attention."

Aparthotel

Full-size fridge, microwave, oven, stovetop

stayAPT Suites Greenville-Haywood Mall

Greenville

"This is a great hotel for the price!!"

Mobile Home

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Apartment

Lake Keowee Resort Condo: Waterfront Balcony

Salem

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Cottage

Families Welcome, Fenced Yard: Inviting Greer Home

Greer

"This property is such an amazing find. Three large bedrooms, very clean and well maintained. Close to town of Greer and all amenities. Very easy check-in. Beds very comfortable. Kitchen well equipped for the week we were there."

Cottage

Cozy Greenville Bungalow ~ 2 Mi to Downtown!

Greenville

"Amazing place. Great host. "

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

Hilton Greenville

10/10 Excellent

"10/10"

Hotel Hartness

8/10 Good

"I have loved this hotel since it opened, and I have given it rave reviews in the past. I stay at least once a year, but this trip was definitely a surprise. If you are a repeat guest and you haven’t been around since December, then you’ll be sad to find as I was that the vibe has changed from what I think made it so special into much more of a Corporate hotel. There was always a breakfast that was free and everybody would gather around eat together, Chat, meet each other like a community. It truly represented the vibe and feel of this property. Sadly that is gone now to almost a Starbucks like counter with prices behind the board and a shopping area.. While I appreciate having an area where I can buy popcorn and drinks if I would like that, it completely changes what made this hotel so special. You can get past that with the amazing restaurant fantastic spa gorgeous ROOMS and refreshing Pool. Sadly, the pool service, which used to have amazing food, with a person there and a bar downstairs seems now at least during the week,, (also Friday) not available any longer. There was just a small little menu and everybody walking all the way up to the building to bring their own drinks down. Not the end of the world but definitely another change that isn’t the spirit of this hotel and both of these decisions made this particular trip, lacking. The property is beautiful, beds are comfortable. Restaurant is fantastic. The staff iA+ it was just better before. Solid B+ to A~"

Best Western Plus Clemson Hotel & Conference Center

8/10 Good

"Room was clean as taff was nice our bathroom pipes were making sounds in the room so they let us Change rooms with no issues. The new girl at the front desk was new and very kind but charged us after we had reservation with Expedia but that is being credited to us. Expedia helped in that situation. But all in all it was a nice comfortable hotel and I would stay again. It was a good location as well."