Hotels near 21c Museum Hotel

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Dec 25 - Dec 26
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Dec 26 - Dec 27
This weekend
Dec 26 - Dec 28
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Jan 2 - Jan 4

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Our top choices for 21c Museum Hotel hotels

Free daily full breakfast
Market Street Inn

Market Street Inn

Market Street Inn
3.5 star property
2.1 km from 21c Museum Hotel
9.8 out of 10, Exceptional, (120)
"I enjoyed my stay, however the breakfast portion was very small even for a petite person like myself, I was still very hungry after breakfast. There was a cleaning issue with the bathroom that was overlooked by the cleaning staff that I alerted the owners to that will hopefully be fixed for future visitors. The house is great and very clean overall. The owners are very nice."
United States
Megan
The price is P10,881
P12,296 total
includes taxes & fees
Dec 28 - Dec 29
Market Street Inn
Front of property
DuPont Mansion Bed & Breakfast

DuPont Mansion Bed & Breakfast

DuPont Mansion Bed & Breakfast
3.0 star property
Old Louisville, 2.8 km from 21c Museum Hotel
9.8 out of 10, Exceptional, (97)
"Breakfast was wonderful, great place to stay!"
United States
Janie
The price is P8,389
P9,737 total
includes taxes & fees
Dec 27 - Dec 28
DuPont Mansion Bed & Breakfast
Exterior
Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
4.0 star property
Downtown Louisville, 0.9 km from 21c Museum Hotel
9.6 out of 10, Exceptional, (428)
"Great location. Great restraunt, great staff. Pleasurable experience!"
United States
Harrison
The price is P10,286
P12,102 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hotel Distil, Autograph Collection
Premium bedding, down comforters, memory foam beds
Stellar Suites

Stellar Suites

Stellar Suites
4.5 star property
East Market District, 2.2 km from 21c Museum Hotel
9.6 out of 10, Exceptional, (117)
"Clean and great location "
United States
Greg
The price is P6,930
P11,111 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Stellar Suites
View from room
The Grady

The Grady

The Grady
4.0 star property
Downtown Louisville, 0.1 km from 21c Museum Hotel
9.4 out of 10, Exceptional, (1003)
"Such an amazing hotel...restaurant is delicious! "
United States
Craig
The price is P8,510
P10,013 total
includes taxes & fees
Jan 1 - Jan 2, 2026
The Grady
Dining
Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row
3.0 star property
Downtown Louisville, 1.2 km from 21c Museum Hotel
9.4 out of 10, Exceptional, (1000)
"The staff and lobby were top tier!"
United States
Emily
The price is P5,591
P6,579 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Cambria Hotel Louisville Downtown-Whiskey Row
Lobby
The Brown Hotel

The Brown Hotel

The Brown Hotel
4.5 star property
Downtown Louisville, 1.2 km from 21c Museum Hotel
9.4 out of 10, Exceptional, (1160)
"Fantastic place to stay in Louisville."
United States
Nathaniel
The Brown Hotel
2 restaurants, breakfast served
Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu
3.5 star property
Phoenix Hill, 2 km from 21c Museum Hotel
9.4 out of 10, Exceptional, (832)
"Clean, quiet and great location "
United States
Kristine
The price is P6,025
P7,089 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Tempo By Hilton Louisville Downtown Nulu
Exterior detail
Central Park Bed & Breakfast

Central Park Bed & Breakfast

Central Park Bed & Breakfast
4.0 star property
Old Louisville, 2.9 km from 21c Museum Hotel
9.4 out of 10, Exceptional, (57)
"Our stay here was excellent in every way! The owners were very sweet and went out of their way to assist us in every way, the rooms were very cozy, and the breakfasts were fantastic. This is the best B&B we've ever stayed."
United States
John
The price is P7,963
P9,243 total
includes taxes & fees
Dec 28 - Dec 29
Central Park Bed & Breakfast
Exterior
Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY
3.0 star property
Downtown Louisville, 0.1 km from 21c Museum Hotel
9.2 out of 10, Wonderful, (1001)
"The room was wonderful and the staff exceptional."
United States
Daniel
The price is P6,020
P7,083 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Homewood Suites by Hilton Louisville Downtown, KY
Front of property
21c Museum Hotel Louisville

21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville, < 0.1 km from 21c Museum Hotel
9.2 out of 10, Wonderful, (1001)
"Staff was very kind, the art was fantastic, location was perfect to explore Whiskey Row, and we had a gorgeous room. Loved our time away there!"
United States
Tammy
The price is P8,164
P9,899 total
includes taxes & fees
Jan 1 - Jan 2, 2026
21c Museum Hotel Louisville
Lobby
Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown
3.0 star property
Downtown Louisville, 0.3 km from 21c Museum Hotel
9.2 out of 10, Wonderful, (517)
"Accommodations were perfect. Staff excellent. Food was very good."
United States
Bennett
The price is P5,697
P6,703 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Towneplace Suites By Marriott Louisville Downtown
Sauna, body treatments, aromatherapy, hot stone massages
Omni Louisville Hotel

Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville, 0.8 km from 21c Museum Hotel
9.2 out of 10, Wonderful, (1739)
"This is a beautiful hotel in a great location. Very kind staff and helpful with directions."
United States
Bonnie
The price is P9,820
P11,554 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Omni Louisville Hotel
Bar (on property)
Moxy Louisville Downtown

Moxy Louisville Downtown

Moxy Louisville Downtown
3.5 star property
Downtown Louisville, 0.9 km from 21c Museum Hotel
9.2 out of 10, Wonderful, (700)
"Awesome location and the staff was super friendly"
United States
Kelly
The price is P6,108
P7,187 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Moxy Louisville Downtown
Exterior
Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
4.0 star property
Downtown Louisville, 0.8 km from 21c Museum Hotel
9.2 out of 10, Wonderful, (57)
"Amazing property! Best hotel in Louisville! Will be staying there again!"
United States
Norman
The price is P9,887
P11,633 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Property amenity
AC Hotel Louisville Downtown

AC Hotel Louisville Downtown

AC Hotel Louisville Downtown
3.5 star property
East Market District, 2 km from 21c Museum Hotel
9.2 out of 10, Wonderful, (607)
"Everything was amazing, staff was wonderful "
United States
Ashley
The price is P6,476
P7,620 total
includes taxes & fees
Jan 9 - Jan 10, 2026
AC Hotel Louisville Downtown
Hypo-allergenic bedding, in-room safe, desk, laptop workspace
Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
4.0 star property
East Market District, 2 km from 21c Museum Hotel
9.2 out of 10, Wonderful, (1019)
"Great location and accommodations."
United States
Steve
The price is P7,459
P8,776 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hotel Genevieve part of JdV by Hyatt
View from property
TownePlace Suites by Marriott Louisville North

TownePlace Suites by Marriott Louisville North

TownePlace Suites by Marriott Louisville North
3.0 star property
2.2 km from 21c Museum Hotel
9.2 out of 10, Wonderful, (645)
"Best hotel and staff ever "
United States
Cheryl
The price is P6,284
P7,101 total
includes taxes & fees
Jan 4 - Jan 5, 2026
TownePlace Suites by Marriott Louisville North
4 restaurants, breakfast, lunch, dinner served; American cuisine
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville, 0.5 km from 21c Museum Hotel
9.0 out of 10, Wonderful, (3883)
"Great place to stay! "
United States
Rochelle
The price is P7,829
P9,212 total
includes taxes & fees
Dec 30 - Dec 31
Galt House Hotel Trademark Collection by Wyndham
Dinner served
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown
4.0 star property
Downtown Louisville, 0.8 km from 21c Museum Hotel
9.0 out of 10, Wonderful, (1122)
"Staff was courteous, hotel was beautiful and clean, and breakfast was amazing!"
United States
Shunskis
The price is P7,176
P8,443 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Embassy Suites Louisville Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top 21c Museum Hotel Hotel Reviews

The Brown Hotel

The Brown Hotel

10/10 Excellent
"All of the above! Love the bars, the gift shop, and the Hot Brown!"
Scott 2-night trip
Posted 2 days ago
The Brown Hotel

Hotels near other 21c Museum Hotel attractions

Louisville Science Center

Louisville Science Center

Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.
See properties
Kentucky Center for the Performing Arts

Kentucky Center for the Performing Arts

Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.
See properties

Frequently asked questions

What's the area like around 21c Museum Hotel?
21c Museum Hotel is located in a family-friendly area of Louisville known for its beautiful river views and great live music scene. If you're looking for a convenient place to stay, check out the 295 hotels and other accommodations you'll find within a mile.
What's the best place to stay near 21c Museum Hotel?
Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Omni Louisville Hotel and Holiday Inn Express & Suites Louisville Downtown by IHG.
How many hotels will I find close to 21c Museum Hotel?
Expedia has 295 hotels and other accommodations within a mile from 21c Museum Hotel.
If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?
Yes! Most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals near 21c Museum Hotel.
What can I see and do near 21c Museum Hotel?
You might want to spend some time browsing the exhibits at Louisville Science Center, Muhammad Ali Center, or Louisville Slugger Museum. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can watch performances at Kentucky Center for the Performing Arts, Louisville Palace, and Derby Dinner Playhouse if you're interested in local theater.