Santa Cruz

Travel Guide

San Lorenzo Cathedral showing a park
San Lorenzo Cathedral showing a park
Santa Cruz featuring a city
San Lorenzo Cathedral featuring heritage elements and heritage architecture
Santa Cruz which includes a city

Experience Bolivia as the locals see it in the country’s busiest city, where the museums, public squares and churches give you a glimpse into their everyday lives.

Although Santa Cruz de la Sierra, more commonly known as Santa Cruz, is the most populous city in Bolivia, it is still relatively unknown by tourists. Sample an authentic Bolivian lifestyle in this busy city. Visit Santa Cruz’s churches and museums for an insight into the region’s history or simply soak up the atmosphere over a drink with the friendly locals.

Explore a city that started out in a totally different location. Santa Cruz was founded in 1561, but had to move west after several decades of fending off attacks. Visit the historic heart of the city in Plaza 24 de SeptiembreOpens in a new window, which is more than 400 years old, to relax with the locals, who are known as “cruceños.”

The most distinctive attraction in the city is San Lorenzo CathedralOpens in a new window, which is immediately recognizable for its red-brick frontage featuring two clock towers standing on either side of a pediment. The cathedral hosts the Museum of Sacred Art, with exhibits that display religious icons and Jesuit relics. Climb to the top of the clock tower for panoramic views of the city.

Wander around the Parque Arenal, a green space in the middle of the city. The park has a boating lagoon and the Museo Etnofolklorico (Santa Cruz Ethnographic Museum). Other museums in the city include the Guarani Museum, which examines the culture of the indigenous Guarani people, and the National History Museum.

Take children to the Zoological Gardens, where they can meet animals from around Bolivia. The zoo’s llamas and sloths are always popular with younger visitors.

Fly into the busiest airport in Bolivia, Viru Viru International Airport. Flights arrive here from destinations in both Bolivia and cities in North and South America. Some operators even fly here from cities in Europe, such as Madrid.

Santa Cruz de la Sierra is located in the lowlands of Bolivia in the east of the country, which means that rainfall is high during the summer months around January. Come during the high season, between May and October, for more dependable weather but higher prices.

Where to stay in Santa Cruz

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Hamacas

While Hamacas isn't home to many top sights, Santa Cruz Zoo and Las Brisas Shopping Center are some notable places to visit nearby.

Hamacas
Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is P2,553 per night from Jan 29 to Jan 30
P2,553
P2,553 total
Jan 29 - Jan 30
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
9.4/10 Exceptional! (82 reviews)
Loved the fact we could check in early for a minimal fee. Staff were nice. The room was good but a bit stuffy and the air conditioning unit had a lot of dirt and dust in it. There was also a weird smell that they sprayed that was a bit nauseating. Otherwise the hotel had a great vibe and was decorated ...

Reviewed on Jan 13, 2026

Ibis Santa Cruz DE LA Sierra
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
The price is P7,798 per night from Jan 31 to Feb 1
P7,798
P7,798 total
Jan 31 - Feb 1
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.8/10 Excellent! (354 reviews)
Indeed this is a First Class hotel. Beautiful lobby, great dining area, beautiful pool, ample rooms.

Reviewed on Jan 17, 2026

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Sun Hotel

Sun Hotel

3.5 out of 5
Av. Banzer Km 13 Santa Cruz Santa Cruz
Fully refundable
The price is P5,780 per night from Jan 23 to Jan 24
P5,780
P5,780 total
Jan 23 - Jan 24
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Play Land Amusement Park is ...
8.2/10 Very Good! (333 reviews)
spotless

Reviewed on Dec 9, 2025

Sun Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

3.5 out of 5
Calle Las Begonias Nro 45 Santa Cruz
Book a stay at this business-friendly apartment in Santa Cruz. Enjoy free WiFi, free parking, and room service. Popular attractions Patio Design LifeStyle Center ...
8.6/10 Excellent! (97 reviews)
Yes, staff were very friendly

Reviewed on Dec 29, 2025

Apart Hotel Premium Suites Santa Cruz
Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol

3.5 out of 5
Calle Las Azucenas No. 127 Santa Cruz Santa Cruz
Book a stay at this business-friendly aparthotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Patio Design LifeStyle ...
8.8/10 Excellent! (82 reviews)
Great folks with there. Clean rooms.

Reviewed on Aug 29, 2025

Premium Suites Deluxe Aparthotel Equipetrol
Equipetrol Suites Apart Hotel

Equipetrol Suites Apart Hotel

2.5 out of 5
Equipetrol Santa Cruz Departamento de Santa Cruz
Book a stay at this business-friendly aparthotel in Santa Cruz. Enjoy free breakfast, free WiFi, and a 24-hour front desk. Popular attractions Cine Center and ...
8.6/10 Excellent! (9 reviews)
Great Staff. Great Location

Reviewed on Dec 29, 2025

Equipetrol Suites Apart Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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