Southeast Missouri

Travel Guide

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
A historic building named 'Poplar Bluff' with a red-tiled roof and brick facade.
A river flowing through a rocky landscape with dense green forest in the background.
A brick building with a sign that reads "Welcome to Historic Downtown Poplar Bluff."
A river surrounded by dense green forest.
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
The price is P6,368 per night from Nov 15 to Nov 16
P6,368
P7,184 total
Nov 15 - Nov 16
includes taxes & fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Drury Plaza Hotel Cape Girardeau Conference Center
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2.5 out of 5
2420 Crestwood Dr Poplar Bluff MO
The price is P5,684 per night from Dec 6 to Dec 7
P5,684
P6,364 total
Dec 6 - Dec 7
includes taxes & fees
Stay at this hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
9.4/10 Exceptional! (1,000 reviews)
"Breakfast very good!"

Reviewed on Nov 13, 2026

Hampton Inn Poplar Bluff
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
The price is P3,464 per night from Nov 23 to Nov 24
P3,464
P3,962 total
Nov 23 - Nov 24
includes taxes & fees
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,004 reviews)
"The room was comfortable. The breakfast was well prepared and well stocked. The parking lot could use more adequate security lighting."

Reviewed on Nov 14, 2026

Baymont Inn and Suites by Wyndham Farmington, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

2 out of 5
7555 State Hwy Y French Village MO
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Lake Wappapello

Lake Wappapello

2 out of 5
8005 Missouri 172 Williamsville MO
Stay at this cabin in Williamsville. Enjoy free parking. Popular attractions Poplar Bluff History Museum and North Main Street Historic District are located ...
Lake Wappapello
Urban Lofts

Urban Lofts

3 out of 5
102 N Jackson St Perryville MO
Stay at this aparthotel in Perryville. Enjoy free WiFi, free parking, and dry cleaning or laundry services. Popular attractions Feltz Street Park and Perryville ...
9.4/10 Exceptional! (22 reviews)
"Beautiful, clean property in the heart of city center. Many options for food and shopping within short walking distance."

Reviewed on Jun 11, 2026

Urban Lofts
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Southeast Missouri attractions

Things to do