Family friendly Hotels in Santee, South Carolina

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Our top choices for Santee family-friendly hotels

Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
2.5 star property
Santee
9.8 out of 10, Exceptional, (1000)
"Staff very friendly, room super clean"
United States
Karine
The price is P7,118
P7,901 total
includes taxes & fees
Jan 21 - Jan 22, 2026
Fairfield Inn & Suites by Marriott Santee

Baymont by Wyndham Santee

Baymont by Wyndham Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1416)
"Room was very nice and staff was very nice"
United States
Rupert
The price is P4,411
P4,896 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Baymont by Wyndham Santee

Hampton Inn Santee-I-95

Hampton Inn Santee-I-95
2.5 star property
Santee
9.6 out of 10, Exceptional, (1001)
"Great place to stop on a road trip! Breakfast was great, pets allowed, friendly staff. "
United States
Stephanie
The price is P7,936
P8,809 total
includes taxes & fees
Jan 20 - Jan 21, 2026
Hampton Inn Santee-I-95

Comfort Inn & Suites Santee

Comfort Inn & Suites Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1008)
"It was quite and comfortable stay"
United States
Shankar
The price is P6,050
P6,716 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Comfort Inn & Suites Santee

Best Western Plus Santee Inn

Best Western Plus Santee Inn
2.5 star property
Santee
8.8 out of 10, Excellent, (1000)
"Nice rooms and very good breakfast items."
United States
Stephen
The price is P6,950
P7,715 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Best Western Plus Santee Inn

Travelodge by Wyndham Santee

Travelodge by Wyndham Santee
2.0 star property
Santee
7.0 out of 10, Good, (683)
"Nice quiet room and a delicious breakfast at a reasonable rate."
United States
Joseph B
The price is P3,590
P3,985 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Travelodge by Wyndham Santee

Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95
2.0 star property
Santee
6.4 out of 10, (545)
"The grounds and property were clean and you could tell they take pride in what they're offering."
United States
Eric
The price is P4,631
P5,140 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Ramada by Wyndham Santee I-95

Econo Lodge Santee

Econo Lodge Santee
2.0 star property
Santee
6.4 out of 10, (310)
"Last minute arrangements stay was quiet and peaceful "
United States
Iasia
The price is P3,722
P4,132 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Econo Lodge Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Santee Hotel Reviews

Frequently asked questions

What's Santee like for family-friendly vacations?
The welcoming destination of Santee is a great choice if you've been thinking about a vacation with the kids. The excursions, lake views, and golfing are just a few things that make this an attractive vacation spot for families. Arrange a flight into Columbia Metropolitan Airport (CAE), which is located 49 mi (78.8 km) from the city center.
What's the best place to stay for families in Santee?
Fairfield Inn & Suites by Marriott Santee is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Comfort Inn & Suites Santee is another choice for your stay with the kids.
When's the best time to book a family-friendly vacation in Santee?
The hottest months are usually July and August with an average temp of 79°F, while the coldest months are January and February with an average of 52°F. Average annual precipitation for Santee is 55 inches.
What's there to see and do with your family in Santee?
While you and your family are visiting Santee, you might want to check out some kid-friendly attractions such as Santee Indian Mound and Fort Watson Site and Orangeburg County Library Mentor Branch. Make sure you have lots of time for activities like Lake Marion and Santee National Wildlife Refuge.

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