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Santa Cruz Vacation Rentals

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Check prices for these dates

In two weeks
Sep 18 - Sep 20
In two months
Oct 30 - Nov 1
In three months
Nov 27 - Nov 29
In four months
Dec 25 - Dec 27

Our top choices for Santa Cruz vacation rentals

A spacious room with a flat-screen TV, a sofa, a small table, a window with curtains, a kitchen area with stools, and a door.

1. la casa de Matias

la casa de Matias
2.0 star property
Volcán
The price is P2,507
P2,757 total
includes taxes & fees
Sep 18 - Sep 19
la casa de Matias
A swing hanging from a tree in a grassy area with a view of a mountain and clouds in the background.

2. Linda Vista Cabins

Linda Vista Cabins
3.0 star property
Alto Boquete
9.2 out of 10, Wonderful, (18 reviews)
"Property was the best local accommodation I have had in Panama. The host was outstanding. "
United States
Don
The price is P3,172
P3,489 total
includes taxes & fees
Sep 6 - Sep 7
Linda Vista Cabins
A covered seating area with two white plastic chairs and a small table, surrounded by neatly trimmed hedges and a palm tree.

3. Casa Little Italy

Casa Little Italy
3.0 star property
Tijeras
6.0 out of 10, (1 review)
"Didn't accept credit card payment "
Mexico
ANGELO
The price is P4,564
P5,020 total
includes taxes & fees
Sep 7 - Sep 8
Casa Little Italy
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

Hotel Faranda Bambito Chiriquí, a member of Radisson Individuals

Hotel Faranda Bambito Chiriquí, a member of Radisson Individuals

10/10 Excellent
"Me gusto todo. La habitación con una vista increíble, el restaurante muy bien atendido y buena cómida. La piscina climatizada es genial"
Dean 9-night trip
Posted 6 days ago
Hotel Faranda Bambito Chiriquí, a member of Radisson Individuals

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

  • View our selection of featured holiday rentals in Santa Cruz
  • Use the map to find apartments and other holiday homes in the Santa Cruz neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Santa Cruz while they last

Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we give you a choice of vacation rentals near top local attractions in Santa Cruz, or you can select a secluded option if you're looking for relaxation.

What's the top vacation rental that Santa Cruz has to offer?

La casa de Matias: This vacation home rental outside of Santa Cruz offers a garden and free WiFi to help you feel comfortable in your new surroundings.

What’s there to see and do in Santa Cruz?

While you're exploring the area, Las Cavernas de Corredores and Área Silvestre Protegida Lagunas de Volcán are a couple of picturesque spots to get outside and enjoy nature. Sitio Barriles Museum and Paradise Tropical Garden are a couple of places you'll find in the larger area.

What’s a vacation rental in Santa Cruz like?

A vacation rental is a private property you can book for a couple of days or more in Santa Cruz. Vacation rentals provide amenities like kitchens and laundry facilities so you'll have everything you want. If you're concerned about a clean environment, a vacation rental can provide a sense of safety away from public hotel elevators and bustling concierge desks while still allowing you to travel. You'll also get more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is an attractive choice for a family trip.