A colonial-style building with a bell tower, palm trees, and a paved walkway.

Luxury Hotels in Santa Cruz, Santa Cruz

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Check availability on Santa Cruz Luxury Hotels

This weekend
Jul 10 - Jul 12
Next weekend
Jul 17 - Jul 19

Our top choices for Santa Cruz luxury hotels

Outdoor pool, pool umbrellas, sun loungers

Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel
5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (236 reviews)
  • cleanliness
    Luxury escape in Santa Cruz's business district offers full-service spa treatments, outdoor pool relaxation, and upscale dining.
The price is P7,505
P7,505 total
Jul 18 - Jul 19
Marriott Santa Cruz de la Sierra Hotel
Reception

Camino Real Hotel

Camino Real Hotel
4.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (430 reviews)
  • cleanliness
    Waterside luxury retreat with full-service spa offers poolside cocktails, garden-view dining, and indoor-outdoor swimming pools.
The price is P8,912
P8,912 total
Aug 4 - Aug 5
Camino Real Hotel
Lobby sitting area

Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra
5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (118 reviews)
  • cleanliness
    Indulge in art deco elegance at this Santa Cruz hotel with luxurious pools and concierge service.
The price is P8,145
P8,145 total
Aug 2 - Aug 3
Novotel Santa Cruz De La Sierra
Massages

Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (87 reviews)
  • cleanliness
    Indulge in spa treatments, outdoor pool relaxation, and friendly concierge service at this entertainment district luxury retreat.
The price is P6,182
P6,182 total
Jul 21 - Jul 22
Swissôtel Santa Cruz De La Sierra
Lounge

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (279 reviews)
  • cleanliness
    Indulge in luxury and convenience at this 4.5-star Bolivia hotel offering fine dining, fitness amenities, and garden views.
The price is P4,521
P4,521 total
Aug 1 - Aug 2
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Exterior detail

TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz
4.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (166 reviews)
The price is P6,026
P6,026 total
Jul 8 - Jul 9
TRYP by Wyndham Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

Frequently asked questions

Are you looking for a luxury hotel for your Santa Cruz vacation?
Travel to Santa Cruz (SRZ-El Trompillo) Airport or Santa Cruz (VVI-Viru Viru Intl.) Airport, and then treat yourself to a stay at one of 6 Santa Cruz luxury hotels. Santa Cruz has some interesting things to see and do including Plaza 24 de Septiembre and Ethno-folkloric Museum, so you might want to take in the local sights during your visit.
What's the best luxury hotel in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Camino Real Hotel and Novotel Santa Cruz De La Sierra are two other upscale options for your stay.
How many luxury hotels will I find in Santa Cruz?
Lie in the lap of luxury during your getaway to Santa Cruz in one of Expedia's 6 luxury hotels.
When can I expect good weather in Santa Cruz?
Planning for the weather is a good way to make your trip to Santa Cruz relaxing and enjoyable, especially when you're splurging. The hottest months are usually October and November with an average temp of 79°F, while the coldest months are June and July with an average of 70°F. Average annual precipitation for Santa Cruz is 48 inches.
What's there to see and do in Santa Cruz?
Enjoy all that Santa Cruz has to offer when you visit Plaza 24 de Septiembre, Ethno-folkloric Museum, and Ramon Tahuichi Aguilera Stadium. If you have a little extra time during your trip, you might want to make a stop at Cine Center and Santa Cruz Zoo.
How can I get around Santa Cruz?
It's easier to get around town comfortably when you know your options. To see more of the larger area, hop on a train at Santa Cruz de la Sierra Station.