A colonial-style building with a bell tower, palm trees, and a paved walkway.

Luxury Hotels in Santa Cruz, Santa Cruz

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Check availability on Santa Cruz Luxury Hotels

Tonight
Oct 4 - Oct 5
Tomorrow
Oct 5 - Oct 6
Next weekend
Oct 9 - Oct 11
In two weeks
Oct 16 - Oct 18

Our top choices for Santa Cruz luxury hotels

A spacious lobby with high ceilings, modern furniture, and large windows allowing natural light.
A restaurant with a long counter, dark chairs, and hanging lights.
A large, illuminated swimming pool surrounded by palm trees and pathways.
A hot tub with a wooden deck and stone walls, surrounded by a pool.

1. Camino Real Hotel

Camino Real Hotel
Santa Cruz
  • Waterside luxury retreat with full-service spa offers poolside cocktails, garden-view dining, and indoor-outdoor swimming pools.
P10,084
P10,084 total
Oct 11 - Oct 12
Camino Real Hotel
A modern restaurant with a city view, featuring glass tables, white chairs, and a large window with curtains.
A hotel room with a large bed, a desk, a chair, a telephone, and a view of the city through large windows.
A modern hotel lobby with a bar area, seating arrangements, and a television.
A small, enclosed garden area with various potted plants and a gravel path.

2. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Santa Cruz
  • Indulge in luxury and convenience at this 4.5-star Bolivia hotel offering fine dining, fitness amenities, and garden views.
P4,604
P4,604 total
Oct 10 - Oct 11
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
A modern hotel with a rooftop pool featuring illuminated blue and purple lights, lounge chairs, and a palm tree.
A luxurious banquet hall with ornate chandeliers, floral arrangements, and elegant table settings.
A modern lobby with a dining area, sofas, and a decorative wall.
A modern lobby with a curved staircase, seating area, and a large wooden bookshelf.

3. Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel
Santa Cruz
  • Luxury escape in Santa Cruz's business district offers full-service spa treatments, outdoor pool relaxation, and upscale dining.
P6,617
P6,617 total
Nov 1 - Nov 2
Marriott Santa Cruz de la Sierra Hotel
A hotel room with a bed, a desk with a chair, a television, and a window with a city view.
A corridor with tiled flooring, potted plants, and a view of a building with a thatched roof.
An aerial view of a residential area with a swimming pool, a playground, and a large building with a red roof.
A lobby with a marble floor, an elevator, and a view of the outdoor seating area.

4. Gran Hotel Santa Cruz

Gran Hotel Santa Cruz
Centro Histórico
P4,053
P4,053 total
Oct 5 - Oct 6
Gran Hotel Santa Cruz
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Top Santa Cruz Hotel Reviews

Frequently asked questions

Are you looking for a luxury hotel for your Santa Cruz vacation?
Travel to Santa Cruz (SRZ-El Trompillo) Airport or Santa Cruz (VVI-Viru Viru Intl.) Airport, and then treat yourself to a stay at one of 7 Santa Cruz luxury hotels. Santa Cruz has some interesting things to see and do including Plaza 24 de Septiembre and Blacutt Square, so you might want to take in the local sights during your visit.
What's the best luxury hotel in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Camino Real Hotel and Hampton by Hilton Santa Cruz/Equipetrol, Bolivia are two other upscale options for your stay.
How many luxury hotels will I find in Santa Cruz?
Lie in the lap of luxury during your getaway to Santa Cruz in one of Expedia's 7 luxury hotels.
When can I expect good weather in Santa Cruz?
Planning for the weather is a good way to make your trip to Santa Cruz relaxing and enjoyable, especially when you're splurging. The hottest months are usually October and November with an average temp of 79°F, while the coldest months are June and July with an average of 70°F. Average annual precipitation for Santa Cruz is 48 inches.
What's there to see and do in Santa Cruz?
Enjoy all that Santa Cruz has to offer when you visit Plaza 24 de Septiembre, Blacutt Square, and Ramon Tahuichi Aguilera Stadium. If you have a little extra time during your trip, you might want to make a stop at Santa Cruz Zoo and Ventura Mall.
How can I get around Santa Cruz?
It's easier to get around town comfortably when you know your options. To see more of the larger area, hop on a train at Santa Cruz de la Sierra Station.