A colonial-style building with a bell tower, palm trees, and a paved walkway.

Luxury Hotels in Santa Cruz, Santa Cruz

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Check availability on Santa Cruz Luxury Hotels

Tonight
Aug 20 - Aug 21
Tomorrow
Aug 21 - Aug 22
This weekend
Aug 21 - Aug 23
Next weekend
Aug 28 - Aug 30

Our top choices for Santa Cruz luxury hotels

1. Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra
Santa Cruz
  • Indulge in spa treatments, outdoor pool relaxation, and friendly concierge service at this entertainment district luxury retreat.
P10,138
P10,138 total
Sep 3 - Sep 4
Swissôtel Santa Cruz De La Sierra

2. Camino Real Hotel

Camino Real Hotel
Santa Cruz
  • Waterside luxury retreat with full-service spa offers poolside cocktails, garden-view dining, and indoor-outdoor swimming pools.
P8,969
P8,969 total
Sep 14 - Sep 15
Camino Real Hotel

3. Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel
Santa Cruz
  • Luxury escape in Santa Cruz's business district offers full-service spa treatments, outdoor pool relaxation, and upscale dining.
P6,539
P6,539 total
Aug 28 - Aug 29
Marriott Santa Cruz de la Sierra Hotel

4. Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra
Santa Cruz
  • Indulge in art deco elegance at this Santa Cruz hotel with luxurious pools and concierge service.
P7,962
P7,962 total
Sep 1 - Sep 2
Novotel Santa Cruz De La Sierra

5. TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz
Santa Cruz
P6,065
P6,065 total
Aug 21 - Aug 22
TRYP by Wyndham Santa Cruz

6. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Santa Cruz
  • Indulge in luxury and convenience at this 4.5-star Bolivia hotel offering fine dining, fitness amenities, and garden views.
P4,550
P4,550 total
Aug 27 - Aug 28
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
View all properties

Top Santa Cruz Hotel Reviews

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

10/10 Excellent
"Great breakfast and beautiful property. Would come here again. Felt safe and comfortable."
Andrew 4-night trip
Posted 4 days ago
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Frequently asked questions

Are you looking for a luxury hotel for your Santa Cruz vacation?
Travel to Santa Cruz (SRZ-El Trompillo) Airport or Santa Cruz (VVI-Viru Viru Intl.) Airport, and then treat yourself to a stay at one of 6 Santa Cruz luxury hotels. Santa Cruz has some interesting things to see and do including Plaza 24 de Septiembre and Ramon Tahuichi Aguilera Stadium, so you might want to take in the local sights during your visit.
What's the best luxury hotel in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Camino Real Hotel and Hampton by Hilton Santa Cruz/Equipetrol, Bolivia are two other upscale options for your stay.
How many luxury hotels will I find in Santa Cruz?
Lie in the lap of luxury during your getaway to Santa Cruz in one of Expedia's 6 luxury hotels.
When can I expect good weather in Santa Cruz?
Planning for the weather is a good way to make your trip to Santa Cruz relaxing and enjoyable, especially when you're splurging. The hottest months are usually October and November with an average temp of 79°F, while the coldest months are June and July with an average of 70°F. Average annual precipitation for Santa Cruz is 48 inches.
What's there to see and do in Santa Cruz?
Enjoy all that Santa Cruz has to offer when you visit Plaza 24 de Septiembre, Ramon Tahuichi Aguilera Stadium, and Cine Center. If you have a little extra time during your trip, you might want to make a stop at Santa Cruz Zoo and Ventura Mall.
How can I get around Santa Cruz?
It's easier to get around town comfortably when you know your options. To see more of the larger area, hop on a train at Santa Cruz de la Sierra Station.