Santa Clara

Panama City

Things to do

Panama Hop-On Hop-Off Bus Tour

City Sightseeing Panama City Hop-On Hop-Off Bus Tour

P1,688
per adult
82% of travellers recommend
City Sightseeing Panama City Hop-On Hop-Off Bus Tour
All Inclusive Taboga Island Catamaran Tour from Panama City

All Inclusive Taboga Island Catamaran Tour from Panama City

P6,177
per adult
90% of travellers recommend
All Inclusive Taboga Island Catamaran Tour from Panama City
From Panama City: San Blas Island Hopping Day Tour

From Panama City: San Blas Island Hopping Day Tour

P9,047
per adult
98% of travellers recommend
From Panama City: San Blas Island Hopping Day Tour
Half day of Panama city and canal tour: shared and private

Half day of Panama city and canal tour: shared and private

P4,168
per adult
96% of travellers recommend
Half day of Panama city and canal tour: shared and private
Slingshot Tour Panama

Slingshot Tour Panama

P7,474
per adult
92% of travellers recommend
Slingshot Tour Panama
Panama Canal Half Transit Experience

Panama Canal Partial Transit

P9,112
per adult
86% of travellers recommend
Panama Canal Partial Transit
See all activities in Panama City

Top hotels in Santa Clara

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
The price is P8,631 per night from Sep 27 to Sep 28
P8,631
P9,495 total
Sep 27 - Sep 28
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
Hotel Riu Plaza Panama
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Plaza de la Independencia Casco Viejo Panama City Panama
The price is P11,501 per night from Oct 12 to Oct 13
P11,501
P12,651 total
Oct 12 - Oct 13
includes taxes & fees
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
9/10 Wonderful! (1,015 reviews)
"Loved my stay! The staff was extremely helpful and the amenities were great!"

Reviewed on Sep 13, 2026

Central Hotel Panama Casco Viejo
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
The price is P7,964 per night from Sep 27 to Sep 28
P7,964
P9,174 total
Sep 27 - Sep 28
includes taxes & fees
Book a stay at this family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
Crowne Plaza Panama Airport by IHG
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz Veracruz Panama
The price is P17,452 per night from Oct 1 to Oct 2
P17,452
P17,452 total
Oct 1 - Oct 2
includes taxes & fees
Book a stay at this beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
Dreams Playa Bonita Panama - All Inclusive
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
The price is P10,954 per night from Sep 16 to Sep 17
P10,954
P12,049 total
Sep 16 - Sep 17
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Megapolis Hotel Panamá
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

4 out of 5
Via Espana 111 Panama City Panama
The price is P5,917 per night from Oct 7 to Oct 8
P5,917
P6,508 total
Oct 7 - Oct 8
includes taxes & fees
Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
7.8/10 Good! (1,004 reviews)
"PÉSIMO en yodos"

Reviewed on Sep 11, 2026

Hotel El Panama by Faranda Grand, a member of Radisson Individuals
See all 1,816 properties in Santa Clara
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Clara

Find the best Santa Clara areas and neighborhoods for the activities you enjoy most.
A coastal cityscape with buildings, a hill with a church, and a clear blue sky.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

A coastal cityscape with high-rise buildings and a curved bay.
Photo by Freddy Dominguez
Open Photo by Freddy Dominguez

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station.

A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

A bridge over a body of water with several boats.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

A coastal cityscape with high-rise buildings, a calm sea, and a rocky shoreline.

Calidonia

You might enjoy the shopping while in Calidonia. Via Espana is a notable sight, and you can get around town at Lotería Station or Santo Tomás Station to see more of the city.

Santa Clara