Santa Clara Vacation Rentals

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Apr 3 - Apr 5
In two months
May 15 - May 17
In three months
Jun 12 - Jun 14
In four months
Jul 10 - Jul 12

Our top choices for Santa Clara vacation rentals

50-inch LED TV with satellite channels

Aparthotel in Costa del Este

Arcadia Condo Suites
2.5 star property
9.4 out of 10, Exceptional, (247 reviews)
"The stay was wonderful and seamless they are very friendly and efficient as always"
United States
Clifford
The price is P7,176
P10,656 total
includes taxes & fees
Mar 27 - Mar 28
Arcadia Condo Suites
TV

Apartment in San Francisco

Living 73 Panamá by Boutique Apartments
3.0 star property
The price is P2,314
P11,316 total
includes taxes & fees
Mar 30 - Mar 31
Living 73 Panamá by Boutique Apartments
Private beach

Villa in Vacamonte

Habitación con entrada Privada en Playa Dorada + Kitchenette y baño.
3.0 star property
10.0 out of 10, Exceptional, (3 reviews)
"Really recommended! Omar is a superhost, very helpfull and lovely! Good facilities and there is a swimmingpool and a nice little beach."
United States
Cynthia
The price is P1,435
P2,210 total
includes taxes & fees
Mar 27 - Mar 28
Habitación con entrada Privada en Playa Dorada + Kitchenette y baño.
Living area

Apartment in Veracruz

Centriqo by Wynwood house
3.0 star property
The price is P8,181
P10,972 total
includes taxes & fees
Apr 19 - Apr 20
Centriqo by Wynwood house
Restaurant

Aparthotel in Casco Viejo

Las Clementinas
3.5 star property
9.4 out of 10, Exceptional, (183 reviews)
"Best of the best, as always!"
United States
Rebecca
The price is P7,629
P8,392 total
includes taxes & fees
Apr 8 - Apr 9
Las Clementinas
Living area

Apartment in San Francisco

Boutique Apartments Panamá Coco del Mar
3.5 star property
7.6 out of 10, Good, (174 reviews)
"The best place "
United States
Julio
The price is P2,960
P11,640 total
includes taxes & fees
Apr 1 - Apr 2
Boutique Apartments Panamá Coco del Mar
Outdoor pool

Apartment in San Francisco

Boutique Apartments Atlapa
3.0 star property
7.6 out of 10, Good, (34 reviews)
"The place was clean nice an its comfortable an the view is to kill for amazing ‼️"
United States
Odaine
Boutique Apartments Atlapa
Free WiFi, bed sheets

Apartment in Amador

La Palma Aparta Suite
3.0 star property
8.4 out of 10, Very Good, (7 reviews)
"All ways clean and ready to used ,no buddy "
United States
Alberto
The price is P4,587
P5,763 total
includes taxes & fees
Mar 23 - Mar 24
La Palma Aparta Suite
Interior detail

Aparthotel in Casco Viejo

La Isabela Suites
3.5 star property
10.0 out of 10, Exceptional, (185 reviews)
"Staying and active in rural Boquete Panama is both a treat and a retreat of relaxation."
United States
Jerry
La Isabela Suites
Exterior

Apartment in Bella Vista

Yoo Panamá by Boutique Apartments
3.5 star property
8.0 out of 10, Very Good, (72 reviews)
"Great Apartment clean, excellent ocean view. "
United States
John
The price is P4,575
P13,344 total
includes taxes & fees
Apr 1 - Apr 2
Yoo Panamá by Boutique Apartments
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Santa Clara Hotel Reviews

Waldorf Astoria Panama

Waldorf Astoria Panama

10/10 Excellent
"The BEST!"
Essence 6-night trip
Posted 6 hours ago
Waldorf Astoria Panama

Find out more about Santa Clara

Search for holiday rentals in Santa Clara on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Clara using one of the methods below:

  • View our selection of featured holiday rentals in Santa Clara
  • Use the map to find apartments and other holiday homes in the Santa Clara neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Santa Clara while they last

Look no further and take a look at our great range of rental properties in Santa Clara!

Frequently asked questions

Can I find vacation rentals in Santa Clara?

Yes, there are vacation rentals close to popular attractions in Santa Clara, or you can choose a secluded option if you'd like a relaxing place to stay. Santa Clara is known for its monuments.

What can I see and do in Santa Clara?

While exploring the area, visit family-friendly sights like Summit Botanical Gardens & Zoo, or get outside and enjoy nature at Culebra Cut. In the larger area, you’ll find Albrook Shopping Mall and Gamboa Rainforest Resort.

What are vacation rentals like in Santa Clara?

Vacation rentals are privately owned properties you can book for several days or longer in Santa Clara. Vacation rentals offer extras such as hot tubs, fire pits, and patios so you'll be comfy for your stay. If you're concerned about cleanliness, a vacation rental can offer a sense of seclusion away from shared hotel elevators and busy reception areas while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a standard hotel, which makes a vacation rental an attractive choice for families.