Santa Clara Vacation Rentals

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Nov 18 - Nov 19
Tomorrow
Nov 19 - Nov 20
This weekend
Nov 21 - Nov 23
Next weekend
Nov 28 - Nov 30

Vacation Rentals in Santa Clara

50-inch LED TV with satellite channels
Arcadia Condo Suites

Arcadia Condo Suites

2.5 star property
Costa del Este
9.4 out of 10, Exceptional, (132)
"Wonderful place great staff "
United States
Shantia
The price is P3,659
P6,748 total
includes taxes & fees
Dec 9 - Dec 10
Arcadia Condo Suites
Terrace/patio
Yoo Panamá by Boutique Apartments

Yoo Panamá by Boutique Apartments

3.5 star property
Bella Vista
8.2 out of 10, Very Good, (44)
"Great place , very clean all good "
United States
harley
The price is P2,916
P11,398 total
includes taxes & fees
Nov 19 - Nov 20
Yoo Panamá by Boutique Apartments
Outdoor pool
Boutique Apartments Panama

Boutique Apartments Panama

3.5 star property
Bella Vista
7.8 out of 10, Good, (202)
"The view was amazing and the place was great could stay here again "
United States
Yonnette
Boutique Apartments Panama
Lobby sitting area
San Francisco by Wynwood House

San Francisco by Wynwood House

3.0 star property
San Francisco
9.2 out of 10, Wonderful, (52)
"This area was perfect for us to walk and check out the local restaurants and coffee shops was really an amazing time! Very close to other major areas so driving and getting around was very convenient:))) all around great stay! "
United States
mario
The price is P6,146
P8,381 total
includes taxes & fees
Nov 19 - Nov 20
San Francisco by Wynwood House
Terrace/patio
La Isabela Suites

La Isabela Suites

3.5 star property
Casco Viejo
10.0 out of 10, Exceptional, (165)
"The room was spotless, the location perfect, and the staff was absolutely superb!"
United States
Gregory
La Isabela Suites
Living area
Torres de Alba Hotel & Suites

Torres de Alba Hotel & Suites

3.5 star property
Bella Vista
8.8 out of 10, Excellent, (478)
"Good location, quick walk to the subway."
United States
Lynden
Torres de Alba Hotel & Suites
Premium bedding, in-room safe, individually decorated
Las Clementinas

Las Clementinas

3.5 star property
Casco Viejo
9.4 out of 10, Exceptional, (168)
"Our stay at Las Clementinas was amazing. The ambiance, decor, and central location to all things in Casco Viejo made our trip magical. Not only was the hotel beautiful, the staff was incredibly warm, helpful and welcoming. The restaurant in the hotel was absolutely delicious. I would stay here ten times over. "
United States
Amanda
The price is P7,628
P8,391 total
includes taxes & fees
Dec 10 - Dec 11
Las Clementinas
Outdoor pool
Studio Apartment with Ocean View

Studio Apartment with Ocean View

3.0 star property
Calidonia
10.0 out of 10, Exceptional, (1)
"Muy amables en general "
Mexico
Algis
Studio Apartment with Ocean View
Outdoor pool
Wanders Panama by Boutique Apartments

Wanders Panama by Boutique Apartments

4.0 star property
San Francisco
10.0 out of 10, Exceptional, (1)
"I will go again thank you so much"
United States
GISY ITZEL
Wanders Panama by Boutique Apartments
Iron/ironing board, free WiFi
Living 73 Panamá by Boutique Apartments

Living 73 Panamá by Boutique Apartments

3.0 star property
San Francisco
Living 73 Panamá by Boutique Apartments
Beach nearby
Habitación Privada en Playa Dorada

Habitación Privada en Playa Dorada

2.0 star property
Vacamonte
The price is P1,414
P2,178 total
includes taxes & fees
Nov 20 - Nov 21
Habitación Privada en Playa Dorada
Living area
Casa del Horno

Casa del Horno

3.0 star property
Casco Viejo
8.6 out of 10, Excellent, (9)
"When I arrived at 3 pm no one was there! i emailed several times with no response, I tries finding a number and there was none, for the hotel or for Hotels.com"
United States
Dave
The price is P4,508
P7,316 total
includes taxes & fees
Nov 19 - Nov 20
Casa del Horno
Balcony
Casa Contemporanea by Wynwood House

Casa Contemporanea by Wynwood House

4.0 star property
Casco Viejo
8.6 out of 10, Excellent, (19)
"Great place!"
United States
Jad
The price is P5,115
P7,099 total
includes taxes & fees
Nov 19 - Nov 20
Casa Contemporanea by Wynwood House
Outdoor pool
Yoo by Wynwood House

Yoo by Wynwood House

4.0 star property
Calidonia
9.2 out of 10, Wonderful, (5)
"I will be back!"
United States
Jeffrey
The price is P5,880
P9,060 total
includes taxes & fees
Nov 25 - Nov 26
Yoo by Wynwood House
Balcony
Casco View Apartments

Casco View Apartments

3.5 star property
Santa Ana
9.2 out of 10, Wonderful, (50)
"Great stay, would recommend."
United States
Brooke
Casco View Apartments
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Santa Clara Hotel Reviews

W Panama

W Panama

10/10 Excellent
"Everything about W Panama Hotel was amazing. I stayed here to celebrate my birthday. The staff was so helpful and polite and went out their way to make sure we enjoyed our stay. Its the small details that make a huge impact. The rooms are beautiful with amazing views. The food was delicious. I have absolutely no complaints and definitely recommend to anyone looking for a great vacation!"
Alvia 6-night trip
Posted 2 days ago
W Panama

Find out more about Santa Clara

Search for holiday rentals in Santa Clara on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Clara using one of the methods below:

  • View our selection of featured holiday rentals in Santa Clara
  • Use the map to find apartments and other holiday homes in the Santa Clara neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Santa Clara while they last

Look no further and take a look at our great range of rental properties in Santa Clara!

Frequently asked questions

Can I find vacation rentals in Santa Clara?

Yes, there are vacation rentals close to popular attractions in Santa Clara, or you can choose a secluded option if you'd like a relaxing place to stay. Santa Clara is known for its monuments.

What can I see and do in Santa Clara?

While exploring the area, visit family-friendly sights like Summit Botanical Gardens & Zoo, or get outside and enjoy nature at Culebra Cut. In the larger area, you’ll find Albrook Shopping Mall and Gamboa Rainforest Resort.

What are vacation rentals like in Santa Clara?

Vacation rentals are privately owned properties you can book for several days or longer in Santa Clara. Vacation rentals offer extras such as hot tubs, fire pits, and patios so you'll be comfy for your stay. If you're concerned about cleanliness, a vacation rental can offer a sense of seclusion away from shared hotel elevators and busy reception areas while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a standard hotel, which makes a vacation rental an attractive choice for families.