Sanctuary Hotels near Sanibel

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Nov 7 - Nov 8
Tomorrow
Nov 8 - Nov 9
This weekend
Nov 7 - Nov 9
Next weekend
Nov 14 - Nov 16

Filter by

Guest rating
Guest rating
Star rating

Top Trending Hotels Near Sanctuary, Sanibel

On the beach, white sand, kayaking, motor boating
Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa

4.0 star property
15.6 km from Sanctuary
8.4 out of 10, Very Good, (1002)
"It is a beautiful resort! It had everything, dining , pool, very relaxing. The staff and rooms were incredible."
United States
Christine
The price is P11,736
P14,560 total
includes taxes & fees
Nov 30 - Dec 1
Marriott Sanibel Harbour Resort & Spa
View from room
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

2.5 star property
21.5 km from Sanctuary
8.8 out of 10, Excellent, (1001)
"This place is a gem! Rooms are so cute and the beach vibe is wonderful. Staff is very friendly and so accommodating. Looking forward to staying again."
United States
Sharon
The price is P10,682
P11,911 total
includes taxes & fees
Dec 6 - Dec 7
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
Aerial view
DiamondHead Beach Resort

DiamondHead Beach Resort

3.5 star property
22.3 km from Sanctuary
9.0 out of 10, Wonderful, (1002)
"Awesome stay "
United States
Suzan
DiamondHead Beach Resort
Interior entrance
Allure Suites

Allure Suites

3.0 star property
27.2 km from Sanctuary
7.6 out of 10, Good, (1001)
"Was clean staff was very nice"
United States
Richard J
The price is P4,713
P5,255 total
includes taxes & fees
Nov 19 - Nov 20
Allure Suites
Outdoor pool
Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel

3.0 star property
19.3 km from Sanctuary
8.6 out of 10, Excellent, (1001)
"Hotel and room very clean, spacious, and a great value for the price "
United States
SYED
The price is P5,589
P6,232 total
includes taxes & fees
Nov 9 - Nov 10
Residence Inn by Marriott Fort Myers Sanibel
Exterior
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

2.5 star property
23.1 km from Sanctuary
9.4 out of 10, Exceptional, (1000)
"Great spot, good staff refreshing "
United States
Roland
The price is P4,942
P5,510 total
includes taxes & fees
Nov 23 - Nov 24
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
Exterior
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

3.0 star property
19.9 km from Sanctuary
8.0 out of 10, Very Good, (1006)
"Clean and comfortable room, friendly staff!!"
United States
Timothy
The price is P5,614
P6,260 total
includes taxes & fees
Dec 1 - Dec 2
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
View from room
Matlacha on Shoreview

Matlacha on Shoreview

2.0 star property
20.2 km from Sanctuary
9.6 out of 10, Exceptional, (200)
"This place is a slice of paradise. We'll be definitely booking again here. "
United States
steve
The price is P3,824
P8,200 total
includes taxes & fees
Nov 8 - Nov 9
Matlacha on Shoreview
Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

3.0 star property
22.9 km from Sanctuary
8.4 out of 10, Very Good, (1000)
"Great stay - really friendly staff"
Germany
Monika
The price is P6,072
P6,770 total
includes taxes & fees
Dec 6 - Dec 7
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
Terrace/patio
Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

3.5 star property
21.8 km from Sanctuary
8.8 out of 10, Excellent, (1009)
" Nice place to stay "
United States
Timothy
The price is P10,952
P13,524 total
includes taxes & fees
Nov 10 - Nov 11
Lani Kai Beachfront Resort
Beach/ocean view
Edison Beach House

Edison Beach House

3.5 star property
21.2 km from Sanctuary
9.4 out of 10, Exceptional, (1548)
"All around great place to stay"
United States
David
The price is P11,814
P14,938 total
includes taxes & fees
Nov 9 - Nov 10
Edison Beach House
Terrace/patio
Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers

3.0 star property
29.5 km from Sanctuary
8.6 out of 10, Excellent, (1034)
"Great hotel loved it"
United States
Jacqueline
The price is P6,542
P7,295 total
includes taxes & fees
Dec 7 - Dec 8
Hilton Garden Inn Ft Myers
Exterior
Candlewood Suites Fort Myers Sanibel Gateway by IHG

Candlewood Suites Fort Myers Sanibel Gateway by IHG

3.0 star property
25.4 km from Sanctuary
7.4 out of 10, Good, (1002)
"It was a great place to stay"
United States
Donald
The price is P4,718
P5,261 total
includes taxes & fees
Nov 24 - Nov 25
Candlewood Suites Fort Myers Sanibel Gateway by IHG
Outdoor pool
Sanibel Island Beach Resort

Sanibel Island Beach Resort

3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (1394)
"Very clean and food was amazing can’t wait to go back "
United States
Donna
The price is P11,944
P14,788 total
includes taxes & fees
Nov 13 - Nov 14
Sanibel Island Beach Resort
Outdoor pool, open 8:00 AM to 10:00 PM, cabanas (surcharge)
The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village

4.0 star property
18.1 km from Sanctuary
9.0 out of 10, Wonderful, (1001)
"It was absolutely a beautiful place!!!"
United States
Paul
The price is P8,606
P11,832 total
includes taxes & fees
Nov 17 - Nov 18
The Westin Cape Coral Resort At Marina Village
Outdoor pool, open 7:30 AM to 9:30 PM, free cabanas, sun loungers
Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina

3.0 star property
22 km from Sanctuary
8.6 out of 10, Excellent, (895)
"Unusual check in and check out and very unique room staff was friendly and helpful "
United States
Gary
Latitude 26 Waterfront Resort & Marina
Free buffet breakfast
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

2.5 star property
23.9 km from Sanctuary
9.2 out of 10, Wonderful, (1000)
"Great stay"
United States
Ubaldo
The price is P6,354
P7,085 total
includes taxes & fees
Nov 23 - Nov 24
Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2 outdoor pools
The Lighthouse Resort Inn & Suites

The Lighthouse Resort Inn & Suites

3.0 star property
21.5 km from Sanctuary
8.6 out of 10, Excellent, (1526)
"Love Lighthouse resort and will ALWAYS go back"
United States
Tracy
The Lighthouse Resort Inn & Suites
Exterior
Sanibel Inn

Sanibel Inn

3.0 star property
East End, 13.8 km from Sanctuary
9.0 out of 10, Wonderful, (1001)
"The reception was welcoming and the room we stayed in was excellent."
United States
Steven
The price is P15,499
P20,692 total
includes taxes & fees
Dec 8 - Dec 9
Sanibel Inn
Bar (on property)
Matanzas Inn Bayside Resort and Marina

Matanzas Inn Bayside Resort and Marina

3.0 star property
21.6 km from Sanctuary
9.2 out of 10, Wonderful, (1000)
"Nice place very enjoyable "
United States
James
The price is P7,501
P9,835 total
includes taxes & fees
Nov 16 - Nov 17
Matanzas Inn Bayside Resort and Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.
Fort Myers which includes a beach
Photo by Sanibel Captiva Chamber of Commerce/Milissa Sprecher Photography
Open Photo by Sanibel Captiva Chamber of Commerce/Milissa Sprecher Photography

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Shell Harbor

Though Shell Harbor might not have many top sights, you can venture to the surrounding area to see attractions like Bailey's Beach and Sanibel Sea School.

Top Sanctuary Hotel Reviews

DiamondHead Beach Resort

DiamondHead Beach Resort

10/10 Excellent
"Everything was great"
Luis 1-night trip
Posted 2 days ago
DiamondHead Beach Resort

Explore a world of travel with Expedia

Frequently asked questions

What is Sanctuary like?
Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels are there in the Sanctuary area?
With 13 Expedia hotels and other accommodations in Sanctuary to choose from, this is a good starting point for exploring the greater Sanibel area.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.
What is there to do around this Sanibel neighborhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.