Sanctuary Hotels near Sanibel

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Dec 22 - Dec 23
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Dec 23 - Dec 24
This weekend
Dec 26 - Dec 28
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Jan 2 - Jan 4

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Our top choices for Sanctuary hotels

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Matlacha on Shoreview

Matlacha on Shoreview

Matlacha on Shoreview
2.0 star property
20.2 km from Sanctuary
9.6 out of 10, Exceptional, (213)
"Place was great. Nice and neat perfect for what i needed."
United States
Michael
The price is P3,230
P7,530 total
includes taxes & fees
Dec 23 - Dec 24
Matlacha on Shoreview
Outdoor pool, open 8:00 AM to 10:00 PM, cabanas (surcharge)
The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village
4.0 star property
18.1 km from Sanctuary
9.0 out of 10, Wonderful, (1004)
"Excellent stay over Thanksgiving holiday!"
United States
Nicole
The price is P9,670
P13,131 total
includes taxes & fees
Dec 23 - Dec 24
The Westin Cape Coral Resort At Marina Village
Balcony view
OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
2.5 star property
25.2 km from Sanctuary
5.8 out of 10, (1004)
"Beautiful place "
United States
Blaine
The price is P7,754
P9,057 total
includes taxes & fees
Jan 2 - Jan 3, 2026
OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
Exterior
Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
2.5 star property
22.6 km from Sanctuary
8.6 out of 10, Excellent, (1002)
"The rooms were clean, staff were very friendly and accommodating."
United States
Sandra
The price is P7,175
P8,000 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
Terrace/patio
Dolphin Key Resort

Dolphin Key Resort

Dolphin Key Resort
3.0 star property
23.8 km from Sanctuary
8.8 out of 10, Excellent, (1210)
"Nice room, helpful staff, nice heated pool, bar/restaurant on site has good prices and live entertainment most nights. Overall, a fun place to stay."
United States
Jacob
The price is P5,872
P6,548 total
includes taxes & fees
Dec 23 - Dec 24
Dolphin Key Resort
Free buffet breakfast
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.4 out of 10, Exceptional, (1071)
"Is great place to stay."
United States
Anastassia
The price is P7,575
P8,446 total
includes taxes & fees
Dec 23 - Dec 24
Holiday Inn Express Cape Coral-Fort Myers Area by IHG
Exterior
Off the Charts Inn & Out Island Resort

Off the Charts Inn & Out Island Resort

Off the Charts Inn & Out Island Resort
2.5 star property
8.8 km from Sanctuary
9.6 out of 10, Exceptional, (144)
"great boutique hotel in an amazing area on Pine Island Fl. Great restaurants and bars walkable and great fishing. "
United States
Pat
The price is P11,163
P14,411 total
includes taxes & fees
Dec 23 - Dec 24
Off the Charts Inn & Out Island Resort
Outdoor pool, a heated pool, sun loungers
Resort Harbour Properties

Resort Harbour Properties

Resort Harbour Properties
3.5 star property
15.7 km from Sanctuary
9.6 out of 10, Exceptional, (364)
"10/10 would stay there again"
United States
Kristie
Resort Harbour Properties
Terrace/patio
White Orchid Apartments

White Orchid Apartments

White Orchid Apartments
2.0 star property
20 km from Sanctuary
8.0 out of 10, Very Good, (49)
"Place was nice and private. "
United States
Dawn
The price is P3,817
P6,155 total
includes taxes & fees
Dec 23 - Dec 24
White Orchid Apartments
Private kitchen
Summerwind Studios

Summerwind Studios

Summerwind Studios
2.0 star property
22.6 km from Sanctuary
8.0 out of 10, Very Good, (11)
"Very clean and roomy. Quiet neighborhood. Loves the shower; so relaxing. Only complaint is that we could have used some drinking glasses. I would stay here again. "
United States
Micki
The price is P3,641
P5,958 total
includes taxes & fees
Dec 24 - Dec 25
Summerwind Studios
Private kitchen
TriLuxe Inn & Studios

TriLuxe Inn & Studios

TriLuxe Inn & Studios
2.0 star property
22.7 km from Sanctuary
8.2 out of 10, Very Good, (17)
"Everything was great, will definitely be coming back"
United States
Ruben
The price is P3,876
P6,220 total
includes taxes & fees
Dec 25 - Dec 26
TriLuxe Inn & Studios
Outdoor pool
Sanibel Island Beach Resort

Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (1479)
"Great place."
United States
Michael
The price is P15,209
P18,426 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Sanibel Island Beach Resort
On the beach, white sand, kayaking, motor boating
Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa
4.0 star property
15.6 km from Sanctuary
8.4 out of 10, Very Good, (1003)
"This was thr best place that we have ever stayed at. "
United States
Matthew
The price is P14,035
P17,117 total
includes taxes & fees
Dec 23 - Dec 24
Marriott Sanibel Harbour Resort & Spa
Exterior
Candlewood Suites Fort Myers Sanibel Gateway by IHG

Candlewood Suites Fort Myers Sanibel Gateway by IHG

Candlewood Suites Fort Myers Sanibel Gateway by IHG
3.0 star property
25.4 km from Sanctuary
7.4 out of 10, Good, (1003)
"Great place to stay."
United States
David
The price is P5,441
P6,066 total
includes taxes & fees
Dec 25 - Dec 26
Candlewood Suites Fort Myers Sanibel Gateway by IHG
Outdoor pool
Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.6 out of 10, Excellent, (1002)
"The property was clean and the breakfast was excellent the staff was friendly and convenient to Sanibel Island"
United States
robert
The price is P7,927
P8,839 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Residence Inn by Marriott Fort Myers Sanibel
Lobby lounge
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
3.0 star property
30.1 km from Sanctuary
8.6 out of 10, Excellent, (789)
"Clean room and very nice staff "
United States
Michael
The price is P5,049
P5,629 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
Terrace/patio
Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers
3.0 star property
29.5 km from Sanctuary
8.8 out of 10, Excellent, (1002)
"Great amenities, pool and spa, clean room, beautiful lobby and good on site restaurant "
United States
Aleksandar
The price is P6,171
P6,880 total
includes taxes & fees
Dec 28 - Dec 29
Hilton Garden Inn Ft Myers
Exterior
Sanibel Inn

Sanibel Inn

Sanibel Inn
3.0 star property
East End, 13.8 km from Sanctuary
9.0 out of 10, Wonderful, (1000)
"Very nice hotel/resort. Clean, quiet, nice pool, attentive staff. Love the screened in balcony. "
Canada
Jonathan
The price is P20,741
P26,531 total
includes taxes & fees
Dec 23 - Dec 24
Sanibel Inn
Exterior
Homewood Suites by Hilton - Fort Myers

Homewood Suites by Hilton - Fort Myers

Homewood Suites by Hilton - Fort Myers
3.0 star property
30.9 km from Sanctuary
9.2 out of 10, Wonderful, (1003)
"Great stay. Excellent staff cleanliness and breakfast was best at any hotel stay"
United States
chad
The price is P7,875
P8,780 total
includes taxes & fees
Dec 24 - Dec 25
Homewood Suites by Hilton - Fort Myers
Exterior
Tarpon Tale Inn

Tarpon Tale Inn

Tarpon Tale Inn
3.0 star property
East End, 14.8 km from Sanctuary
9.6 out of 10, Exceptional, (392)
"Great staff, close to the beach. Provided beach chairs, umbrella, & beach cart for stay. Highly recommend"
United States
Thomas
The price is P13,154
P14,666 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Tarpon Tale Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.
Fort Myers which includes a beach
Photo by Sanibel Captiva Chamber of Commerce/Milissa Sprecher Photography
Open Photo by Sanibel Captiva Chamber of Commerce/Milissa Sprecher Photography

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

Shell Harbor

Though Shell Harbor might not have many top sights, you can venture to the surrounding area to see attractions like Sanibel Sea School and Dunes Golf and Tennis Club.

Top Sanctuary Hotel Reviews

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

10/10 Excellent
"Yes, Molly the front desk very helpful"
Yamilet 2-night trip
Posted 17 hours ago
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Frequently asked questions

What is Sanctuary like?
Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels are there in the Sanctuary area?
With 12 Expedia hotels and other accommodations in Sanctuary to choose from, this is a good starting point for exploring the greater Sanibel area.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.
What is there to do around this Sanibel neighborhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

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