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San Francisco Hotels

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Oct 1 - Oct 2
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Oct 2 - Oct 3
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Oct 2 - Oct 4
Next weekend
Oct 9 - Oct 11

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Our top choices for San Francisco hotels

A pool area with lounge chairs and a covered seating area, surrounded by modern buildings.
A spacious lobby with a central water feature, multiple seating areas, and a curved ceiling with hanging lights.
A modern hotel with a prominent entrance, outdoor seating area, and a handicap-accessible parking space.
A spacious lobby with modern seating, a central coffee table, and decorative hanging lights.

1. Hotel Mykonos Panama

Hotel Mykonos Panama
Nuevo Santiago
United States
Ismael
P5,632
P6,196 total
includes taxes & fees
Oct 2 - Oct 3
Hotel Mykonos Panama
A pool surrounded by palm trees and a tiled roof structure.
A hallway with a glass partition leading to a dining area, a stone wall, and a metal gate with decorative patterns.
A spacious room with a high ceiling, a large window, and a wooden door leading to another area. There are several potted plants and a small table with a vase.
A building with a curved facade, a balcony with metal railings, and a door with a sign.

2. Hotel Gran David

Hotel Gran David
Santiago
United States
Roxani
P4,788
P5,266 total
includes taxes & fees
Oct 3 - Oct 4
Hotel Gran David
A swimming pool with a water slide, surrounded by palm trees and lounge chairs.
A spacious dining area with high ceilings, large windows, and natural light. Tables are set with chairs and centerpieces.
A multi-story hotel with balconies, a pool, and a reflection in the water.
A hammock suspended between two white walls in a room with a balcony.

3. HOTEL VISTA LAGO

HOTEL VISTA LAGO
La Pena
United States
Hedwig
P4,788
P5,266 total
includes taxes & fees
Oct 4 - Oct 5
HOTEL VISTA LAGO
A modern lobby with a sofa, armchairs, a desk, and a large window offering a view of the cityscape.
A lobby with a reception desk, two armchairs, a sofa, and a table with a lamp.
A bathroom with a tiled shower wall, a sink, and a towel rack.
A hotel room with two single beds, a desk with a chair, a television, and a door.

4. Hotel Plaza Los Tucanes

Hotel Plaza Los Tucanes
Nuevo Santiago
United States
James
P3,244
P3,569 total
includes taxes & fees
Oct 2 - Oct 3
Hotel Plaza Los Tucanes
Restaurant
A blue building with a tiled porch, surrounded by lush greenery and a garden.
A room with two beds, a refrigerator, and a coat rack.
Hotel Anachoreo with a corrugated metal roof, surrounded by tropical vegetation.

5. Hotel Anachoreo

Hotel Anachoreo
Santa Fe
United States
John
P5,291
P5,821 total
includes taxes & fees
Oct 2 - Oct 3
Hotel Anachoreo
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Top San Francisco Hotel Reviews

HOTEL VISTA LAGO

HOTEL VISTA LAGO

10/10 Excellent
"Todo perfecto"
Michele 2-night trip
Posted 12 days ago
HOTEL VISTA LAGO
La Qhia Eco Retreat

La Qhia Eco Retreat

10/10 Excellent
"This is a beautiful property but remember it is somewhat rustic. The neighborhood roosters make sure to wake you. The rooms are comfortable and with the mountain air and ceiling fan you don’t miss AC. Free breakfast was tasty. Dinner was good but lunch is not available. The best part is the well maintained landscaping. We were fortunate to have a peaceful rainy day that was heaven on the covered patio with hammocks. The staff is friendly & helpful."
Patricia 3-night trip
Posted 3 weeks ago
La Qhia Eco Retreat
Hotel Plaza Los Tucanes

Hotel Plaza Los Tucanes

10/10 Excellent
"Excelente"
Olopilel 1-night trip
Posted 1 month ago
Hotel Plaza Los Tucanes
Hotel Galería

Hotel Galería

10/10 Excellent
"Hay un restaurante en el hotel con desayuno y comida económica y muy sabrosa. La ubicación del hotel es muy céntrica. Es seguro. Tiene centro comercial al lado. Parqueo de carro seguro. Es perfecto para una visita a Santiago."
Lionel 1-night trip
Posted 6 months ago
Hotel Galería

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Frequently asked questions

What's the best place for a stay in San Francisco?
Hotel Mykonos Panama, located 10.4 mi (16.8 km) from the heart of San Francisco, is a top choice for your stay based on our traveler data. Other good options for your trip to the area are Hotel Gran David and HOTEL VISTA LAGO. See all available top hotels, or vacation rentals in San Francisco.
If I need to cancel my hotel reservation in San Francisco, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in San Francisco.
What is staying in San Francisco like?
Visitors to San Francisco are sure to find plenty to explore and enjoy. There are 18 hotels and other accommodations in the surrounding area. Find out more about San Francisco.
What should I see while I'm in San Francisco?
Places to visit in the wider area include Laguna de La Yeguada, Parque Acuatico Italia Guadalupe Panama, and Catedral of Santiago Apostol. You'll also find Los Pozos Termales and Omar Torrijos Herrera Stadium in the area. Check out what more to see and do in Expedia's San Francisco guide.
What's the weather like in San Francisco?
The hottest months are usually March and April with an average temp of 80°F, while the coldest months are January and December with an average of 77°F. The rainiest months in San Francisco are October, August, June, and November, with each month seeing an average of 18 inches of rainfall.