San Francisco Hotels

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Our top choices for San Francisco hotels

Hotel Anachoreo

Hotel Anachoreo
3.0 star property
Santa Fe
9.6 out of 10, Exceptional, (38 reviews)
  • cleanliness
    Set in downtown Santa Fe, this cozy B&B offers massages and authentic meals nearby.
"Wonderful location with absolutely breathing taking views! Room was quite large with a seating area. Beds comfortable but could use slightly better pillows. "
United States
Gwendolyn J
Hotel Anachoreo

Rainforest Yasmin Hotel

Rainforest Yasmin Hotel
2.5 star property
Santa Fe
Rainforest Yasmin Hotel

Hotel Galería

Hotel Galería
3.0 star property
Nuevo Santiago
8.4 out of 10, Very Good, (208 reviews)
  • cleanliness
    Escape to Nuevo Santiago with two outdoor pools and a welcoming bar.
"Everything was nice!"
United States
Daniel
The price is P3,995
P4,395 total
includes taxes & fees
Feb 19 - Feb 20
Hotel Galería

Hotel Mykonos Panama

Hotel Mykonos Panama
3.5 star property
Nuevo Santiago
8.8 out of 10, Excellent, (548 reviews)
  • cleanliness
    Modern spa retreat in Nuevo Santiago with 3 pools and holistic services.
"Everything was nice room, staff, amenities!"
United States
Daniel
The price is P5,223
P5,745 total
includes taxes & fees
Feb 17 - Feb 18
Hotel Mykonos Panama

Hotel Gran David

Hotel Gran David
3.5 star property
Santiago
8.6 out of 10, Excellent, (373 reviews)
  • cleanliness
    Splash into comfort at Santiago's premier hotel with a poolside bar to unwind.
"Clean and pleasant. The restaurant has an excellent menu."
United States
Brenda
Hotel Gran David

HOTEL VISTA LAGO

HOTEL VISTA LAGO
3.0 star property
La Pena
9.2 out of 10, Wonderful, (92 reviews)
  • cleanliness
    Experience a serene oasis with panoramic lake views at this La Pena retreat.
"Great atmosphere around the restaurant and pool. We found it very relaxing in an otherwise busy city. Restaurant makes good meals and the service is great."
Canada
Conrad
The price is P4,439
P4,883 total
includes taxes & fees
Feb 17 - Feb 18
HOTEL VISTA LAGO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

What's the best place for a stay in San Francisco?
Hotel Gran David, located 9.5 mi (15.4 km) from the heart of San Francisco, is a top choice for your stay based on our traveler data. Other good options for your trip to the area are Hotel Mykonos Panama and HOTEL VISTA LAGO. See all available top hotels, or vacation rentals in San Francisco.
If I need to cancel my hotel reservation in San Francisco, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in San Francisco.
What is staying in San Francisco like?
Visitors to San Francisco are sure to find plenty to explore and enjoy. There are 17 hotels and other accommodations in the surrounding area. Find out more about San Francisco.
What should I see while I'm in San Francisco?
Places to visit in the wider area include Laguna de La Yeguada, Parque Acuatico Italia Guadalupe Panama, and Catedral of Santiago Apostol. You'll also find Los Pozos Termales and Omar Torrijos Herrera Stadium in the area. Check out what more to see and do in Expedia's San Francisco guide.
What's the weather like in San Francisco?
The hottest months are usually March and April with an average temp of 80°F, while the coldest months are January and December with an average of 77°F. The rainiest months in San Francisco are October, August, June, and November, with each month seeing an average of 18 inches of rainfall.