San Francisco Hotels

Hotel Mykonos Panama, located 10.4 mi (16.8 km) from the heart of San Francisco, is a top choice for your stay based on our traveler data. Other good options for your trip to the area are Hotel Gran David and Hotel Galería. See all available top hotels, or vacation rentals in San Francisco.

Yes! You'll find that most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in San Francisco.

To find more details about picking new dates or cancelling your trip to San Francisco, click here.

Visitors to San Francisco are sure to find plenty to explore and enjoy. There are 16 hotels and other accommodations in the surrounding area. Find out more about San Francisco.

Places to visit in the wider area include Parque Acuatico Italia Guadalupe Panama, Laguna de La Yeguada, and Parque Nacional Cerro Hoya. You'll also find Catedral of Santiago Apostol and Los Pozos Termales in the area. Check out what more to see and do in Expedia's San Francisco guide.

The hottest months are usually March and April with an average temp of 80°F, while the coldest months are January and December with an average of 77°F. The rainiest months in San Francisco are October, August, June, and November, with each month seeing an average of 18 inches of rainfall.