San Francisco Hotels

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Check prices for these dates

This weekend
May 22 - May 24
Next weekend
May 29 - May 31

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Our top choices for San Francisco hotels

Interior

Hotel Plaza Los Tucanes

Hotel Plaza Los Tucanes
3.0 star property
Nuevo Santiago
10.0 out of 10, Exceptional, (4 reviews)
"This super convenient hotel was a delight and a surprise. Very clean updated and right off the Pan American Highway. Excellent room and the industrial scale but home cooked goodness of the fonda downstairs just perfect. We will 100% plan on staying here every trip."
Canada
Philip
The price is P3,200
P3,520 total
includes taxes & fees
May 19 - May 20
Hotel Plaza Los Tucanes
Outdoor pool

HOTEL VISTA LAGO

HOTEL VISTA LAGO
3.0 star property
La Pena
9.4 out of 10, Exceptional, (112 reviews)
"Great place to stay, quiet…"
United States
Eduardo
The price is P4,722
P5,194 total
includes taxes & fees
May 19 - May 20
HOTEL VISTA LAGO
Outdoor pool, free cabanas, pool umbrellas

Hotel Gran David

Hotel Gran David
3.5 star property
Santiago
8.6 out of 10, Excellent, (401 reviews)
"Good hotel, good service and good breakfast"
Mexico
Kayser
The price is P4,722
P5,194 total
includes taxes & fees
May 19 - May 20
Hotel Gran David
Restaurant

Hotel Anachoreo

Hotel Anachoreo
3.0 star property
Santa Fe
9.6 out of 10, Exceptional, (43 reviews)
"Great stay"
United States
John
The price is P5,219
P5,741 total
includes taxes & fees
May 20 - May 21
Hotel Anachoreo
3 outdoor pools, free cabanas, pool umbrellas

Hotel Mykonos Panama

Hotel Mykonos Panama
3.5 star property
Nuevo Santiago
8.8 out of 10, Excellent, (577 reviews)
"Very nice property and an excellent room "
United States
Larry
The price is P4,938
P5,432 total
includes taxes & fees
May 21 - May 22
Hotel Mykonos Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top San Francisco Hotel Reviews

Hotel Plaza Los Tucanes

Hotel Plaza Los Tucanes

10/10 Excellent
"I had to go downstairs to be served eggs and fruit. Everything was wonderful."
Debprah 1-night trip
Posted 1 hour ago
Hotel Plaza Los Tucanes

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Frequently asked questions

What's the best place for a stay in San Francisco?
Hotel Mykonos Panama, located 10.4 mi (16.8 km) from the heart of San Francisco, is a top choice for your stay based on our traveler data. Other good options for your trip to the area are Hotel Gran David and HOTEL VISTA LAGO. See all available top hotels, or vacation rentals in San Francisco.
If I need to cancel my hotel reservation in San Francisco, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in San Francisco.
What is staying in San Francisco like?
Visitors to San Francisco are sure to find plenty to explore and enjoy. There are 19 hotels and other accommodations in the surrounding area. Find out more about San Francisco.
What should I see while I'm in San Francisco?
Places to visit in the wider area include Parque Acuatico Italia Guadalupe Panama, Laguna de La Yeguada, and Catedral of Santiago Apostol. You'll also find Los Pozos Termales and Omar Torrijos Herrera Stadium in the area. Check out what more to see and do in Expedia's San Francisco guide.
What's the weather like in San Francisco?
The hottest months are usually March and April with an average temp of 80°F, while the coldest months are January and December with an average of 77°F. The rainiest months in San Francisco are October, August, June, and November, with each month seeing an average of 18 inches of rainfall.