Skip to Main Content.
List your propertySupportTrips
Member discount illustration
Members save 10% or more on over 100,000 hotels worldwide when you’re signed in
Sign in
Learn about Expedia Rewards
Feedback

Hotel Sant' Anna

3.0 star property
Hotel with a 24-hour front desk, 9-minute walk to St. Peter's Basilica

Choose dates to view prices

Photo gallery for Hotel Sant' Anna

1 bedroom, hypo-allergenic bedding, minibar, in-room safe
Reception
Front of property
Courtyard
Reception
Hotel Sant' Anna offers a tranquil escape near Vatican Museums and St. Peter's Basilica. Guests love the serene garden, in-room WiFi, and practical amenities like luggage storage. The 24-hour front desk staff consistently earns praise for their helpful service.
VIP Access

Reviews

9.6 out of 10
Exceptional

Popular amenities

  • 24/7 front desk
  • Housekeeping
  • Air conditioning
  • Free WiFi

Get more when you're a member

  • Save 15% or more on select VIP Access properties when you reach Silver tier or higher
  • Experience top-rated quality and exceptional service
  • Get an in-stay perk at select properties, plus free room upgrades, early check-in, and late check-out when available

Room options

Available filters for rooms
Showing 6 of 6 rooms

View all photos for Classic Double Room, 1 Bedroom

1 bedroom, hypo-allergenic bedding, minibar, in-room safe

Classic Double Room, 1 Bedroom

10.0 out of 10
Exceptional
(9 reviews)

Highlights

Air conditioning
Flat-screen TV
Hypo-allergenic bedding
Separate bedroom
Blackout drapes/curtains
Rainfall showerhead
Bidet
Hair dryer
  • 18 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 Queen Bed

View all photos for Classic Triple Room

1 bedroom, hypo-allergenic bedding, minibar, in-room safe

Classic Triple Room

10.0 out of 10
Exceptional
(1 review)

Highlights

Air conditioning
Free cribs/infant beds
Flat-screen TV
Hypo-allergenic bedding
Separate bedroom
Blackout drapes/curtains
Rainfall showerhead
Bidet
  • 25 sq m
  • Sleeps 3
  • 1 Double Bed and 1 Twin Bed

View all photos for Classic Quadruple Room

1 bedroom, hypo-allergenic bedding, minibar, in-room safe

Classic Quadruple Room

10.0 out of 10
Exceptional
(1 review)

Highlights

Air conditioning
Free cribs/infant beds
Flat-screen TV
Hypo-allergenic bedding
Separate bedroom
Blackout drapes/curtains
Rainfall showerhead
Bidet
  • 28 sq m
  • Sleeps 4
  • 1 Queen Bed and 2 Twin Beds

View all photos for Double Room Single Use

1 bedroom, hypo-allergenic bedding, minibar, in-room safe

Double Room Single Use

Highlights

Air conditioning
Flat-screen TV
Hypo-allergenic bedding
Blackout drapes/curtains
Separate bedroom
Rainfall showerhead
Bidet
Hair dryer
  • 18 sq m
  • Sleeps 1
  • 1 Queen Bed

View all photos for Basic Double Room

1 bedroom, hypo-allergenic bedding, minibar, in-room safe

Basic Double Room

10.0 out of 10
Exceptional
(4 reviews)

Highlights

Air conditioning
Flat-screen TV
Hypo-allergenic bedding
Blackout drapes/curtains
Separate bedroom
Rainfall showerhead
Bidet
Hair dryer
  • 16 sq m
  • Sleeps 2
  • 1 Queen Bed

View all photos for Classic Double Room, 1 Bedroom

1 bedroom, hypo-allergenic bedding, minibar, in-room safe

Classic Double Room, 1 Bedroom

9.6 out of 10
Exceptional
(4 reviews)

Highlights

Air conditioning
Flat-screen TV
Hypo-allergenic bedding
Separate bedroom
Blackout drapes/curtains
Rainfall showerhead
Bidet
Hair dryer
  • 18 sq m
  • 1 bedroom
  • Sleeps 2
  • 2 Twin Beds

You may also like

Ad
Reception

Hilton Rome Eur La Lama

EUR
  • Pet friendly
  • Free WiFi
  • Restaurant
  • Air conditioning
8.8 out of 10, Excellent, 249 reviews
The price is P10,280
P12,324 total
includes taxes & fees
Dec 1 - Dec 2
Hilton Rome Eur La Lama
Mod logo
Sign in to view eligible discounts and perks. More rewards for more adventures!
Sign inSign up, it's free

About the neighborhood

Map
via borgo pio 134, Rome, RM, 193

What's nearby

  • St. Peter's Basilica - 7 min walk - 0.6 km
  • Sistine Chapel - 7 min walk - 0.6 km
  • Vatican Museums - 8 min walk - 0.7 km
  • Piazza Navona - 16 min walk - 1.4 km
  • Pantheon - 19 min walk - 1.7 km

Getting around

  • Risorgimento/S. Pietro Tram Stop - 5 min walk
  • Rome San Pietro Station - 15 min walk
  • Ciampino Airport (CIA) - 49 min drive

Restaurants

  • ‪Il Pozzetto - ‬1 min walk
  • ‪Ristorante Venerina - ‬1 min walk
  • ‪Ristorante Interno 92 - ‬1 min walk
  • ‪Arlu - ‬1 min walk
  • ‪Borgosteria - ‬1 min walk

About this property

Hotel Sant' Anna

Hotel near Sistine Chapel
A short walk from St. Peter's Basilica and Vatican Museums, Hotel Sant' Anna provides a garden and more. Guests can connect to free in-room WiFi.
Other perks at this hotel include:
  • Buffet breakfast (surcharge), luggage storage, and a 24-hour front desk
  • Concierge services and smoke-free premises
  • Guest reviews speak highly of the helpful staff and location
Room features
All guestrooms at Hotel Sant' Anna include perks such as air conditioning, in addition to amenities like free WiFi and safes.
Other amenities include:
  • Bidets, free toiletries, and hair dryers
  • Wardrobes/closets, electric kettles, and daily housekeeping

Similar properties

Rooftop terrace

Hotel Isa

  • Pet friendly
  • Free WiFi
  • Air conditioning
  • Business services
9.4 out of 10, Exceptional, 1,028 reviews
Hotel Isa

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • No onsite parking available

Food and drink

  • Daily buffet breakfast available 7:00 AM to 10:00 AM for a fee: EUR 15 per person

Conveniences

  • 24-hour front desk
  • Luggage storage

Guest services

  • Concierge services
  • Housekeeping (daily)

Outdoors

  • Garden

Accessibility

  • Hardwood flooring in room
  • No elevator

More

  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes
  • Hypo-allergenic bedding

Bathroom

  • Bidet
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Entertainment

  • Flat-screen TV

Food and drink

  • Coffee/tea maker
  • Electric kettle
  • Minibar

More

  • Air conditioning (climate-controlled)
  • Desk
  • Free local calls
  • Phone
  • Safe

Policies

Check-in

Check-in start time: 1 PM; Check-in end time: midnight
Late check-in subject to availability
Minimum check-in age: 18

Check-out

Check-out before 10:30 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
If you are planning to arrive after midnight please contact the property in advance using the information on the booking confirmation
For any questions, please contact the property using the information on the booking confirmation
Guests staying at the apartments should go the hotel's main address to check in.

Renovations and closures

The property is closed between August 11 and August 22.

Access methods

Staffed front desk

Pets

Pets not allowed

Children and extra beds

Children are welcome
Rollaway/extra beds are not available

Property payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • A tax is imposed by the city: EUR 6.00 per person, per night, up to 10 nights. This tax does not apply to children under 10 years of age.

We have included all charges provided to us by the property.

Optional extras

  • Fee for buffet breakfast: approximately EUR 15 per person

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards, debit cards, and cash
Safety features at this property include a carbon monoxide detector, a fire extinguisher, and a smoke detector
Please note that cultural norms and guest policies may differ by country and by property; the policies listed are provided by the property
Property Registration Number IT058091A1AJXSQ7XJ

We should mention

This property does not have elevators
All guests, including children, must be present at check-in and show their government-issued photo ID card or passport
Cash transactions at this property cannot exceed EUR 5000, due to national regulations; for further details, please contact the property using information in the booking confirmation
Only registered guests are allowed in the guestrooms

National rating

This property has received its official star rating from the local rating authority.

Property is also known as

Hotel Sant' Anna Rome
Hotel Sant' Anna
Sant' Anna Rome
Sant Anna Rome
Sant Anna Hotel Rome
Hotel Sant' Anna Rome
Hotel Sant' Anna Hotel
Hotel Sant' Anna Hotel Rome

Frequently asked questions

Is Hotel Sant' Anna pet-friendly?

No, pets are not allowed at this property.

How much is parking at Hotel Sant' Anna?

This property doesn't offer parking.

What time is check-in at Hotel Sant' Anna?

Check-in start time: 1 PM; Check-in end time: midnight. Late check-in is available during limited hours.

What time is check-out at Hotel Sant' Anna?

Check-out is at 10:30 AM.

Where is Hotel Sant' Anna located?

Located in Rome City Centre, this hotel is within a 10-minute walk of St. Peter's Square, St. Peter's Basilica, and Sistine Chapel. Vatican Museums and Castel Sant'Angelo are also within 15 minutes. Risorgimento/S. Pietro Tram Stop is only a 5-minute walk and Ottaviano - San Pietro - Musei Vaticani Station is 10 minutes.

Have a question?

AI iconBeta

Get instant answers with AI powered search of property information and reviews.

Reviews

Hotel Sant' Anna Reviews

9.6

Exceptional

9.8

Cleanliness

9.4

Location

9.8

Staff & service

9.2

Eco-friendliness

9.4

Property conditions & facilities
Rating 10 - Excellent. 255 out of 319 reviews
Rating 8 - Good. 49 out of 319 reviews
Rating 6 - Okay. 11 out of 319 reviews
Rating 4 - Poor. 3 out of 319 reviews
Rating 2 - Terrible. 1 out of 319 reviews

Reviews

10/10 Excellent

Stephen

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Wonderful location, very helpful service and staff!
Stayed 4 nights in Aug 2025

10/10 Excellent

Cherry

Liked: Cleanliness, staff & service, property conditions & facilities
Very friendly staff. Free breakfast with the stay.
Stayed 3 nights in Sep 2025

10/10 Excellent

Susan

Liked: Cleanliness, amenities, property conditions & facilities
Great location, amazing staff!
Stayed 1 night in Jun 2025

10/10 Excellent

Cherry

Liked: Cleanliness, staff & service, property conditions & facilities
Very hospitable front desk staff. Will be staying here from now on everytime Rome tugs at my heartstrings!
Stayed 1 night in Oct 2025

10/10 Excellent

DIANE

Liked: Cleanliness, staff & service, property conditions & facilities
This hotel is very quaint near everything to walk. The front desk was very nice and helpful and polite. Nice breakfast in the morning too. I would definitely stay here again.
Stayed 2 nights in Jul 2025

10/10 Excellent

Barry A

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Extremely nice and helpful staff. Room was very quaint and great access to a lot of tourist spots within a mile. Room was cleaned every day. Highly recommend
Stayed 9 nights in Aug 2025

10/10 Excellent

Lynn

Liked: Cleanliness, amenities, property conditions & facilities
Great little hotel very near the Vatican. Very clean and typically Roman. Lovely.
Stayed 2 nights in Jun 2025

10/10 Excellent

Cathy

Liked: Amenities
The staff was outstanding. Very helpful and friendly. Location very walkable, close to Vatican and also short walk to subway, etc the room was comfortable and shower had good water pressure.
Stayed 4 nights in May 2025

10/10 Excellent

Larry

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Wonderful place to stay. Also, very convenient for walking to the Vatican and other sites. Staff is very friendly.
Stayed 3 nights in Aug 2024

10/10 Excellent

Rocio Escobar de

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Nice hotel located in a beautiful historical pedestrian street . Staff is really friendly and helpful.
Stayed 4 nights in Nov 2023

10/10 Excellent

Vidmary

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We were so happy to stay close to the Vatican. Great staff.
Stayed 2 nights in Jun 2024

10/10 Excellent

Jeff

Liked: Cleanliness, staff & service
Employees more than helpful. Great access to Vatican
Stayed 1 night in Oct 2024

10/10 Excellent

JANICE

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
This hotel is a beautiful hotel built in the 16th century. Very close to the Vatican and many other historical sites. Many dining options. The people at the front desk were very helpful for any thing we needed. Highly recommend this hotel!
Stayed 8 nights in Aug 2024

10/10 Excellent

Dave

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Friendly knowledgable helpful team, service is excellent. Breakfast is quite good
Stayed 11 nights in Nov 2023

10/10 Excellent

Robert

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Would stay again

Hotel is convenient as to is very close to Vatican and other attractions. Hotel is historic structure built in the 1500s. It was refurbished appt 1970 and has all the modern features a traveler would want. Staff is very accommodating and helpful. Lots of restaurants are close by. Would stay there again.
Stayed 3 nights in May 2024

10/10 Excellent

Lillian

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
The hotel is wonderfully situated, the staff are friendly and helpful. The room was comfortable. The breakfast is sufficiently varied to suit most any taste. This is my go-to place in Rome.
Stayed 4 nights in Sep 2022

10/10 Excellent

Eleanor

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Splendid, classy property -- very old school and dignified as suits its proximity to the Holy See. We visit Rome often and this is easily one of the best hotels just blocks from St. Peter's basilica. Bravo to discreet and capable hotel team!
Stayed 3 nights in Jul 2023

10/10 Excellent

Daniel

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Perfect location! Only two blocks away from St. Peter's Square with several great restaurants within walking distance. Room was clean and comfortable. Staff was friendly and helpful with local attractions, restaurant options, and tips getting around. Also, best gelato in Rome is next door.
Stayed 1 night in Jul 2023

10/10 Excellent

Anna Luisa

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean. Helpful staff. Close to St. Peter's Basilica
Stayed 4 nights in Jul 2024

10/10 Excellent

Julia

Grazie mille!

We adored our short stay! The staff was so friendly and hospitable. They allowed us to store our bags for a few hours after check-out when our flight out of Rome got delayed, which was greatly appreciated. The room itself was clean and well-appointed with a comfortable bed, and the bathroom was modern! The hotel itself had a lot of character and was close to the Vatican and tons of restaurants and shops. Grazie mille!
Stayed 1 night in Jan 2025

6/10 Okay

Verified traveler

Hotel Near Vatican

Fair hotel for our trip to Italy and specifically for a visit near the Vatican. The hotel does feel aged and could use some updates, but it met our basic needs.
Stayed 2 nights in Nov 2023

10/10 Excellent

Nicholas

Liked: Amenities, property conditions & facilities
Sant Anna is in a fantastic position to explore the city. It’s small and chic. About 2 minute walk to the Vatican and a ten minute walk over the river to the centre. Staff were friendly and helpful. All in all an ideal place to stay when visiting Rome. Would be more than happy to stay there again.
Stayed 7 nights in Sep 2023

10/10 Excellent

fred

Service, cooperation and kindness are extraordinary. Location is superb. Excellent restaurants On the same street. One block from St. Peter’s Basilica. Easy walking distance to Metro. Room is very comfortable, large area, bathroom excellent. Highly recommend based on my world travels I give Sanna an A
Stayed 1 night in Oct 2023

10/10 Excellent

John

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

A lovely old and serene Roman hotel

Sant'Anna is lovely. We had a wonderful stay in this beautifully presented 16th century hotel. Our room was even better than described online. It is very close to the Vatican and only a few minutes stroll from St Peter's. The hotel staff are all really professional and friendly. Marcello made us most welcome and took care of everything we asked about. We loved meeting Nina the dog who calmly dozes near reception and gracefully brings a cozy ambience to the hotel! One of the nicest hotels we've ever stayed in.
Stayed 6 nights in Jun 2024

10/10 Excellent

Laura

Liked: Cleanliness, staff & service, property conditions & facilities
The staff is very welcoming and helpful. We had a late arrival due to flight delays and they were very accomodating.. The breakfast is a simple continental breakfast however the freshly made espresso is amazing. The hotel is situated one street from the Vatican and 10 minute walk from the Castel Sant Angelo. We took the bus from the Airport to the hotel and our location was easy accessible. I highly recommend this hotel and I definitely will stay here again in a future visit to Rome.
Stayed 2 nights in Jul 2022