O Brien Hotels

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Top 10 trending O Brien hotels

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 star property
9.4 out of 10, Exceptional, (1000)
"My family and I loved our stay. "
The price is P6,482
P7,293 total
includes taxes & fees
Aug 24 - Aug 25
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Hampton Inn & Suites Alachua I-75

2.5 star property
9.4 out of 10, Exceptional, (436)
"Friendly staff, bed was comfortable "
The price is P6,636
P7,465 total
includes taxes & fees
Aug 12 - Aug 13
Hampton Inn & Suites Alachua I-75

Americas Best Value Inn Alachua

2.0 star property
4.8 out of 10, (572)
"clean, check in easy"
The price is P3,852
P4,334 total
includes taxes & fees
Aug 7 - Aug 8
Americas Best Value Inn Alachua

La Quinta Inn & Suite by Wyndham Lake City

2.5 star property
8.8 out of 10, Excellent, (1005)
"Great place for the night on way to Sarasota. "
The price is P5,369
P6,041 total
includes taxes & fees
Aug 7 - Aug 8
La Quinta Inn & Suite by Wyndham Lake City

Comfort Suites Lake City

2.5 star property
9.6 out of 10, Exceptional, (1000)
"Amazing place to stay"
The price is P5,339
P6,006 total
includes taxes & fees
Aug 12 - Aug 13
Comfort Suites Lake City

Postcard Cabins Gilchrist Springs

2.0 star property
10.0 out of 10, Exceptional, (67)
"This places was beautiful and perfect for our Family time,"
The price is P6,827
P9,718 total
includes taxes & fees
Aug 10 - Aug 11
Postcard Cabins Gilchrist Springs

Best Western Plus Lake City

2.5 star property
9.2 out of 10, Wonderful, (1002)
"Room was clean, breakfast was good, and staff was very pleasant. "
The price is P4,620
P5,198 total
includes taxes & fees
Aug 12 - Aug 13
Best Western Plus Lake City

Quality Inn Lake City

2.5 star property
7.8 out of 10, Good, (913)
"Great location right off the interstate"
The price is P4,589
P5,163 total
includes taxes & fees
Aug 7 - Aug 8
Quality Inn Lake City

Baymont by Wyndham Lake City

2.5 star property
5.2 out of 10, (1001)
"Easy check-in and friendly front desk staff. The room was very clean and the bed was comfy!"
The price is P3,413
P3,840 total
includes taxes & fees
Aug 12 - Aug 13
Baymont by Wyndham Lake City

Days Inn by Wyndham Lake City I-10

2.0 star property
6.8 out of 10, (1000)
"It s a very nice hotel"
The price is P3,901
P4,389 total
includes taxes & fees
Aug 12 - Aug 13
Days Inn by Wyndham Lake City I-10

High Springs Country Inn

2.0 star property
7.6 out of 10, Good, (5)
"Ive had a stay at this price point with better arrangement such as breakfast included. However, for only one night it wasnt too bad. Room is too dark. Lighter colors in the room luke greish would make it look more cozy."
The price is P4,169
P4,690 total
includes taxes & fees
Aug 13 - Aug 14
High Springs Country Inn

Tru by Hilton Lake City

2.5 star property
9.2 out of 10, Wonderful, (1006)
"The hotel was very clean, the staff as friendly and helpful and the bed was soooo comfortable!"
The price is P4,974
P5,595 total
includes taxes & fees
Aug 21 - Aug 22
Tru by Hilton Lake City

Fairfield Inn & Suites Lake City

2.5 star property
9.0 out of 10, Wonderful, (117)
"The staff was friendly and helpful."
The price is P4,827
P5,431 total
includes taxes & fees
Aug 7 - Aug 8
Fairfield Inn & Suites Lake City

BlueGem Motel

2.0 star property
9.2 out of 10, Wonderful, (361)
"Amazing owners"
The price is P5,757
P6,477 total
includes taxes & fees
Aug 11 - Aug 12
BlueGem Motel

Courtyard By Marriott Lake City

3.0 star property
9.6 out of 10, Exceptional, (124)
"Great hotel "
The price is P5,507
P6,196 total
includes taxes & fees
Aug 17 - Aug 18
Courtyard By Marriott Lake City

Quality Inn White Springs Suwanee

2.5 star property
7.2 out of 10, Good, (563)
"Very nice place to stop for the night "
The price is P4,566
P5,023 total
includes taxes & fees
Aug 27 - Aug 28
Quality Inn White Springs Suwanee

Americas Best Value Inn Lake City

2.0 star property
8.8 out of 10, Excellent, (1000)
"I have been going here on and off for 10 years to see my kids and grandkids. The staff and management are friendly. "
The price is P4,079
P4,589 total
includes taxes & fees
Aug 10 - Aug 11
Americas Best Value Inn Lake City

Holiday Inn & Suites Lake City by IHG

3.0 star property
8.6 out of 10, Excellent, (1000)
"Great place to stay friendly staff clean rooms"
The price is P4,761
P5,357 total
includes taxes & fees
Aug 17 - Aug 18
Holiday Inn & Suites Lake City by IHG

Hampton Inn & Suites Lake City

2.5 star property
9.4 out of 10, Exceptional, (1001)
"Nice stay"
The price is P5,679
P6,389 total
includes taxes & fees
Aug 24 - Aug 25
Hampton Inn & Suites Lake City

Days Inn by Wyndham Lake City I-75

2.0 star property
7.4 out of 10, Good, (1001)
"Nice, clean comfortable place to sleep for a decent price"
The price is P3,852
P4,334 total
includes taxes & fees
Aug 12 - Aug 13
Days Inn by Wyndham Lake City I-75
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Learn more about O Brien

Explore attractions like Suwannee River and Ichetucknee River as you discover things to see and do in O Brien.

Photo by Dr__Vlad
Open Photo by Dr__Vlad

Top O Brien Hotel Reviews

Frequently asked questions

Where is the best place to stay in O Brien?

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG, located 29.9 mi (48.2 km) from the heart of O Brien, is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Postcard Cabins Gilchrist Springs and La Quinta Inn & Suite by Wyndham Lake City. See all available top hotels, or vacation rentals in O Brien.

If I need to cancel my hotel reservation in O Brien, will I receive a refund?

Yes! You'll find that most hotel reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.

Where can I learn more about changing or cancelling my trip to O Brien?

To access more information about picking new dates or cancelling your trip to O Brien, click here.

Where is the best hotel to stay near Ichetucknee Springs State Park?

Escape to Nature - 2 miles from Ichetucknee park is one of the top choices for your stay based on our traveler data, and this property features in-room kitchens and fireplaces. It's located 2.3 mi (3.8 km) from Ichetucknee Springs State Park. Another good choice is A Riverview of a Magical Sunrise every morning, located 5.6 mi (9.1 km) away.

What are some accommodations with pools in O Brien?

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG: Provides buffet, an outdoor pool, and complimentary wired internet access. La Quinta Inn & Suite by Wyndham Lake City and Tru by Hilton Lake City are two additional hotels that feature an onsite pool. View all hotels with pools in O Brien.

What's the best hotel for staying near Gainesville Regional Airport (GNV)?

Hampton Inn & Suites Gainesville Downtown is one of the top choices for your stay and is a popular hotel, featuring free breakfast and an outdoor pool. It's located 3.7 mi (6 km) from Gainesville Regional Airport. Other good choices close to the airport include Sweetwater Branch Inn and Travelers Inn.

How is it to stay in O Brien?

Visitors to O Brien are sure to find plenty to explore and enjoy. In O Brien, there are 10 hotels and other accommodations to choose from. Find out more about O Brien.

What should I see while I'm in O Brien?

Natural beauty is on display at Suwannee River, Ichetucknee River, and Ichetucknee Springs State Park. You'll also find Troy Spring State Park and Wes Skiles Peacock Springs State Park in the area. Check out what more to see and do in Expedia's O Brien guide.

What's the seasonal weather like in O Brien?

The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 58°F. Average annual precipitation for O Brien is 50 inches.