O Brien Hotels

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Nov 19 - Nov 20
Tomorrow
Nov 20 - Nov 21
This weekend
Nov 21 - Nov 23
Next weekend
Nov 28 - Nov 30

Filter by

Guest rating
Guest rating
Star rating

Top 10 trending O Brien hotels

Exterior
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 star property
Alachua
9.4 out of 10, Exceptional, (1000)
"Great clean place to stay. "
United States
Mary
The price is P6,784
P7,632 total
includes taxes & fees
Dec 1 - Dec 2
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Desk, blackout drapes, iron/ironing board, rollaway beds
Americas Best Value Inn Alachua

Americas Best Value Inn Alachua

2.0 star property
Alachua
4.8 out of 10, (595)
"Staff was helpful and so courteous.."
United States
Christian
The price is P4,468
P5,026 total
includes taxes & fees
Nov 27 - Nov 28
Americas Best Value Inn Alachua
Breakfast area
Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75

2.5 star property
Alachua
9.4 out of 10, Exceptional, (466)
"Nice room only there for one night"
United States
Laryssa
The price is P5,994
P6,743 total
includes taxes & fees
Dec 11 - Dec 12
Hampton Inn & Suites Alachua I-75
Exterior
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

2.5 star property
Lake City
8.8 out of 10, Excellent, (1010)
"Excellent hotel. Spacious rooms, comfortable bed, great breakfast and friendly staff. Directly off I-75 for easy on and off. "
United States
Lisa
The price is P5,215
P5,867 total
includes taxes & fees
Dec 1 - Dec 2
La Quinta Inn & Suite by Wyndham Lake City
Lobby
Best Western Plus Lake City

Best Western Plus Lake City

2.5 star property
Lake City
9.2 out of 10, Wonderful, (1005)
"Clean room, friendly staff "
United States
Bill
The price is P4,779
P5,376 total
includes taxes & fees
Dec 1 - Dec 2
Best Western Plus Lake City
Property amenity
Courtyard By Marriott Lake City

Courtyard By Marriott Lake City

3.0 star property
Lake City
9.6 out of 10, Exceptional, (169)
"Nice place for a weekend trip to the springs close by.Would definitely stay here again."
United States
Mary
The price is P6,312
P7,102 total
includes taxes & fees
Nov 30 - Dec 1
Courtyard By Marriott Lake City
Laptop workspace, free WiFi
High Springs Country Inn

High Springs Country Inn

2.0 star property
High Springs
8.6 out of 10, Excellent, (13)
"Great remodel of a retro motel."
United States
Kathleen
The price is P4,619
P5,197 total
includes taxes & fees
Nov 23 - Nov 24
High Springs Country Inn
Lobby
Comfort Suites Lake City

Comfort Suites Lake City

2.5 star property
Lake City
9.6 out of 10, Exceptional, (1002)
"We love to stop here when traveling to Orlando"
United States
Bridget
The price is P5,967
P6,713 total
includes taxes & fees
Dec 7 - Dec 8
Comfort Suites Lake City
Exterior
Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy

2.0 star property
High Springs
9.8 out of 10, Exceptional, (138)
"Amazing getaway ,, I love the amenities and the firewood and everything was amazing great service perfect escape from reality."
United States
Emperesse
The price is P7,012
P10,306 total
includes taxes & fees
Nov 20 - Nov 21
Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy
Exterior
Tru by Hilton Lake City

Tru by Hilton Lake City

2.5 star property
Lake City
9.2 out of 10, Wonderful, (1005)
"Clean room, easy check in and out, staff if very friendly and helpful"
United States
Row
The price is P6,430
P7,235 total
includes taxes & fees
Nov 23 - Nov 24
Tru by Hilton Lake City
Desk, laptop workspace, blackout drapes, iron/ironing board
Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee

2.5 star property
Live Oak
7.2 out of 10, Good, (604)
"Clean rooms, very friendly staff"
United States
Kristin L
The price is P4,012
P4,413 total
includes taxes & fees
Dec 4 - Dec 5
Quality Inn White Springs Suwanee
Individually decorated, desk, laptop workspace, iron/ironing board
Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10

2.0 star property
Lake City
6.8 out of 10, (1001)
"Was quite and clean, a little dated but it was a good place to sleep they are pet friendly "
United States
William
The price is P3,304
P3,717 total
includes taxes & fees
Nov 20 - Nov 21
Days Inn by Wyndham Lake City I-10
Outdoor pool
Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75

2.5 star property
Lake City
5.0 out of 10, (1001)
"Just a perfect place to take a break while traveling. Clean,comfortable and a great staff. "
United States
Cris
The price is P3,410
P3,836 total
includes taxes & fees
Nov 20 - Nov 21
Baymont by Wyndham Lake City I-75
Lobby
Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City

2.5 star property
Lake City
9.0 out of 10, Wonderful, (153)
"Clean property and nice staff"
United States
Thomas
The price is P5,782
P6,504 total
includes taxes & fees
Nov 30 - Dec 1
Fairfield Inn & Suites Lake City
Outdoor pool, sun loungers
Quality Inn Lake City

Quality Inn Lake City

2.5 star property
Lake City
7.8 out of 10, Good, (944)
"Very nice place, would definitely stay there again!"
United States
Gerald
The price is P4,400
P4,950 total
includes taxes & fees
Dec 20 - Dec 21
Quality Inn Lake City
Lobby
Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center

2.0 star property
Lake City
8.4 out of 10, Very Good, (44)
"Great little motel with extremely nice staff. "
United States
Georgiy
The price is P3,079
P3,464 total
includes taxes & fees
Nov 30 - Dec 1
Motel 6 – Lake City, Fl – Medical Center
Reception
BlueGem Motel

BlueGem Motel

2.0 star property
High Springs
9.2 out of 10, Wonderful, (383)
"Great place to stay."
United States
Wesley
The price is P6,579
P7,401 total
includes taxes & fees
Nov 23 - Nov 24
BlueGem Motel
BBQ/picnic area
Americas Best Value Inn Lake City

Americas Best Value Inn Lake City

2.0 star property
Lake City
8.8 out of 10, Excellent, (1001)
"Great value, super polite staff, and clean, comfortable rooms"
United States
chelsea
The price is P4,212
P4,739 total
includes taxes & fees
Nov 20 - Nov 21
Americas Best Value Inn Lake City
Lobby
Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City

2.5 star property
Lake City
9.4 out of 10, Exceptional, (1001)
"It was a great stay "
United States
Miranda
The price is P5,380
P6,053 total
includes taxes & fees
Nov 30 - Dec 1
Hampton Inn & Suites Lake City
Pillowtop beds, in-room safe, desk, blackout drapes
Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75

2.0 star property
Lake City
7.4 out of 10, Good, (1000)
"We stay at this motel several times a year. It is always clean, the staff is always friendly and welcoming. We wouldn’t stay anywhere else."
United States
Troy
The price is P3,962
P4,457 total
includes taxes & fees
Dec 1 - Dec 2
Days Inn by Wyndham Lake City I-75
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida

Top O Brien Hotel Reviews

Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center

10/10 Excellent
"Clean, easy experience. Thanks "
Samantha 1-night trip
Posted 2 days ago
Motel 6 – Lake City, Fl – Medical Center

More cheap stays in O Brien

Best Western Plus Lake City

Best Western Plus Lake City

350 SW Florida Gateway Dr Lake City FL
The price is P4,779 per night from Dec 1 to Dec 2
P4,779
P5,376 total
Dec 1 - Dec 2
includes taxes & fees
9/10 Wonderful! (1,002 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?
Best Western Plus Lake City, located 17.9 mi (28.8 km) from the heart of O Brien, is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are La Quinta Inn & Suite by Wyndham Lake City and Holiday Inn Express & Suites Alachua - Gainesville Area by IHG. See all available top hotels, or vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
What are some accommodations with pools in O Brien?
Best Western Plus Lake City: Offers a snack bar/deli, an indoor pool, and buffet. La Quinta Inn & Suite by Wyndham Lake City and Holiday Inn Express & Suites Alachua - Gainesville Area by IHG are two additional hotels that feature an onsite pool. View all hotels with pools in O Brien.
How is it to stay in O Brien?
Visitors to O Brien are sure to find plenty to explore and enjoy. In O Brien, there are 10 hotels and other accommodations to choose from. Find out more about O Brien.
What should I see while I'm in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River, and Ichetucknee Springs State Park. You'll also find Lafayette Blue Springs State Park and Lake City Mall in the area. Check out what more to see and do in Expedia's O Brien guide.
What's the seasonal weather like in O Brien?
The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 58°F. Average annual precipitation for O Brien is 50 inches.

Explore a world of travel with Expedia