O Brien Hotels
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Go beyond your typical stay in O Brien
Pet friendly
Check prices for these dates
Top 10 trending O Brien hotels

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
9.4 out of 10, Exceptional, (1006)
The price is P6,450
P7,256 total
includes taxes & fees
Aug 24 - Aug 25

Hampton Inn & Suites Alachua I-75
Hampton Inn & Suites Alachua I-75
9.4 out of 10, Exceptional, (440)
The price is P6,398
P7,197 total
includes taxes & fees
Aug 24 - Aug 25

Americas Best Value Inn Alachua
Americas Best Value Inn Alachua
4.8 out of 10, (574)
The price is P3,104
P3,492 total
includes taxes & fees
Aug 20 - Aug 21

Courtyard By Marriott Lake City
Courtyard By Marriott Lake City
9.6 out of 10, Exceptional, (128)
The price is P5,708
P6,421 total
includes taxes & fees
Aug 25 - Aug 26

La Quinta Inn & Suite by Wyndham Lake City
La Quinta Inn & Suite by Wyndham Lake City
8.8 out of 10, Excellent, (1001)
The price is P5,342
P6,010 total
includes taxes & fees
Aug 19 - Aug 20

Comfort Suites Lake City
Comfort Suites Lake City
9.6 out of 10, Exceptional, (1002)
The price is P5,624
P6,327 total
includes taxes & fees
Aug 20 - Aug 21
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Learn more about O Brien
Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

Photo by Dr__Vlad
Open Photo by Dr__Vlad
Top O Brien Hotel Reviews

La Quinta Inn & Suite by Wyndham Lake City
10/10 Excellent
More cheap stays in O Brien
More cheap stays in O Brien

La Quinta Inn & Suite by Wyndham Lake City
165NW CALI DRIVE, Lake City, FL
The price is P5,342 per night from Aug 19 to Aug 20
P5,342
P6,010 total
Aug 19 - Aug 20
includes taxes & fees
8.6/10 Excellent! (1,001 reviews)
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Near an Attraction
Hotels Near O Brien, Florida
- Florida Panhandle Hotels
- Lake City Hotels
- High Springs Hotels
- Gulf Coast Hotels
- Alachua Hotels
- Perry Hotels
- Live Oak Hotels
- White Springs Hotels
- Fort White Hotels
- Southeastern United States Hotels
- Old Town Hotels
- Newberry Hotels
- Central West Coast Florida Hotels
- Madison Hotels
- Branford Hotels
- Northern Florida Hotels
- Jasper Hotels
- Mayo Hotels
- Lake Butler Hotels
- Trenton Hotels
More ways to book
Expedia's Latest Trends
Hotels
- Hotels in South Beach
- Hotels with shuttle in Tinley Park
- Hotels with smoking rooms in Evansville
- 3 Star Hotels in International Drive District
- Hotels in Ithaca
- Hotels in Antioch
- Hotels with free parking in Honolulu
- Hotels in Escondido
- Hotels near Walt Disney World® Resort
- Hotels with smoking rooms in Dubuque
Packages
General