O Brien Hotels

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Jan 4 - Jan 5
Tomorrow
Jan 5 - Jan 6
Next weekend
Jan 9 - Jan 11
In two weeks
Jan 16 - Jan 18

Filter by

Guest rating
Guest rating
Star rating

Our top choices for O Brien hotels

Exterior
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 star property
Alachua
9.4 out of 10, Exceptional, (1007)
"Great stay. Good breakfast. "
United States
Bob
The price is P6,887
P7,748 total
includes taxes & fees
Jan 7 - Jan 8
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Breakfast area
Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
2.5 star property
Alachua
9.4 out of 10, Exceptional, (478)
"Good overnight experience on a car trip. Nice staff."
United States
Luis
The price is P6,130
P6,896 total
includes taxes & fees
Feb 1 - Feb 2
Hampton Inn & Suites Alachua I-75
Exterior
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
2.5 star property
Lake City
8.8 out of 10, Excellent, (1039)
"Very clean property and a full hot breakfast buffet! "
United States
Julie
The price is P5,775
P6,497 total
includes taxes & fees
Feb 1 - Feb 2
La Quinta Inn & Suite by Wyndham Lake City
Exterior
Tru by Hilton Lake City

Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1009)
"Cleanliness friendly service, very good free breakfast."
United States
Marsha
The price is P5,903
P6,640 total
includes taxes & fees
Jan 11 - Jan 12
Tru by Hilton Lake City
Lobby
Best Western Plus Lake City

Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1033)
"Great place to stay"
United States
Jack
The price is P5,816
P6,543 total
includes taxes & fees
Jan 6 - Jan 7
Best Western Plus Lake City
Lobby
Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1006)
"Clean room, staff, everyone super helpful ."
United States
Devang
The price is P7,475
P8,410 total
includes taxes & fees
Jan 11 - Jan 12
Hampton Inn & Suites Lake City
Lobby
Comfort Suites Lake City

Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.6 out of 10, Exceptional, (1001)
"Great staff"
United States
Alison
The price is P6,304
P7,091 total
includes taxes & fees
Jan 11 - Jan 12
Comfort Suites Lake City
Lobby
Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (176)
"Very clean, friendly staff, safe and quiet "
United States
Amy
The price is P5,768
P6,490 total
includes taxes & fees
Jan 11 - Jan 12
Fairfield Inn & Suites Lake City
Exterior
Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
3.0 star property
Lake City
8.6 out of 10, Excellent, (1003)
"Great place"
United States
John
The price is P5,592
P6,291 total
includes taxes & fees
Jan 11 - Jan 12
Holiday Inn & Suites Lake City by IHG
Exterior
Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.2 out of 10, Good, (670)
"It was clean, quiet, safe."
United States
donna
The price is P3,903
P4,390 total
includes taxes & fees
Jan 7 - Jan 8
Super 8 by Wyndham Lake City
BBQ/picnic area
Americas Best Value Inn Lake City

Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.8 out of 10, Excellent, (1004)
"We had a good stay, the room was clean, check in quick and easy, the bed was comfortable."
United States
Alan
The price is P3,953
P4,447 total
includes taxes & fees
Jan 6 - Jan 7
Americas Best Value Inn Lake City
Pillowtop beds, in-room safe, desk, blackout drapes
Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
2.0 star property
Lake City
7.6 out of 10, Good, (1007)
"Staff was great"
United States
Thomas
The price is P3,720
P4,185 total
includes taxes & fees
Jan 6 - Jan 7
Days Inn by Wyndham Lake City I-75
Desk, laptop workspace, blackout drapes, iron/ironing board
Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
2.5 star property
Live Oak
7.2 out of 10, Good, (622)
"Clean rooms, very friendly staff"
United States
Kristin L
The price is P4,003
P4,403 total
includes taxes & fees
Jan 18 - Jan 19
Quality Inn White Springs Suwanee
Exterior
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
2.0 star property
High Springs
10.0 out of 10, Exceptional, (162)
"Fantastic place! Very nice amenities and service was wonderful"
United States
Annette
The price is P4,953
P10,628 total
includes taxes & fees
Jan 13 - Jan 14
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
Terrace/patio
Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
3.0 star property
Lake City
9.4 out of 10, Exceptional, (742)
"This is an excellent hotel while you roadtrip:)"
United States
Desiree Moreno
The price is P6,986
P7,859 total
includes taxes & fees
Jan 11 - Jan 12
Home2 Suites by Hilton Lake City
Outdoor pool, sun loungers
Quality Inn Lake City

Quality Inn Lake City

Quality Inn Lake City
2.5 star property
Lake City
7.8 out of 10, Good, (956)
"very clean room, great staff, we will be staying there again when we come to see our daughter "
United States
Gary
The price is P3,953
P4,447 total
includes taxes & fees
Feb 3 - Feb 4
Quality Inn Lake City
1 bedroom, laptop workspace, free WiFi, bed sheets
Vista Verde Farm Retreat

Vista Verde Farm Retreat

Vista Verde Farm Retreat
2.0 star property
Lake City
9.6 out of 10, Exceptional, (14)
"This is my second time staying on this property and I love it "
United States
brandie
The price is P5,933
P10,593 total
includes taxes & fees
Jan 6 - Jan 7
Vista Verde Farm Retreat
Iron/ironing board, free WiFi, bed sheets
Regal Inn

Regal Inn

Regal Inn
2.5 star property
Lake City
8.6 out of 10, Excellent, (548)
"Comfortable bed, roomy bathroom. Negative:barn door separating bedroom & bathroom (affects privacy), no clothes hangers. "
United States
Linda
The price is P3,652
P4,108 total
includes taxes & fees
Jan 7 - Jan 8
Regal Inn
Reception
BlueGem Motel

BlueGem Motel

BlueGem Motel
2.0 star property
High Springs
9.2 out of 10, Wonderful, (398)
"Beautiful room, very clean and the bed was incredibly soft and comfortable to sleep in! "
United States
Julians
The price is P5,253
P5,910 total
includes taxes & fees
Jan 8 - Jan 9
BlueGem Motel
Property amenity
Courtyard By Marriott Lake City

Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (182)
"Nice place for a weekend trip to the springs close by.Would definitely stay here again."
United States
Mary
The price is P6,298
P7,086 total
includes taxes & fees
Jan 11 - Jan 12
Courtyard By Marriott Lake City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida

Top O Brien Hotel Reviews

Americas Best Value Inn Lake City

Americas Best Value Inn Lake City

10/10 Excellent
"The place was clean. Carpets not sticky. We got a smoking room, my husband is smoke free and he said it didn't smell like a ash tray. Quiet place. "
ReBecca 1-night trip
Posted 1 day ago
Americas Best Value Inn Lake City

More cheap stays in O Brien

Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center

3340 W US Highway 90 Lake City FL
The price is P3,943 per night from Feb 1 to Feb 2
P3,943
P4,436 total
Feb 1 - Feb 2
includes taxes & fees
8/10 Very Good! (89 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?
La Quinta Inn & Suite by Wyndham Lake City, located 18.2 mi (29.3 km) from the heart of O Brien, is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and Tru by Hilton Lake City. See all available top hotels, or vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
What are some accommodations with pools in O Brien?
La Quinta Inn & Suite by Wyndham Lake City: Offers on-the-go, an indoor pool, and free self parking. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and Tru by Hilton Lake City are two additional hotels that feature an onsite pool. View all hotels with pools in O Brien.
How is it to stay in O Brien?
Visitors to O Brien are sure to find plenty to explore and enjoy. In O Brien, there are 11 hotels and other accommodations to choose from. Find out more about O Brien.
What should I see while I'm in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River, and Ichetucknee Springs State Park. You'll also find Wes Skiles Peacock Springs State Park and Lafayette Blue Springs State Park in the area. Check out what more to see and do in Expedia's O Brien guide.
What's the seasonal weather like in O Brien?
The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 58°F. Average annual precipitation for O Brien is 50 inches.

Explore a world of travel with Expedia