Mark Twain Hotels near St. Louis

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Dec 19 - Dec 20
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Dec 20 - Dec 21
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Dec 19 - Dec 21
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Dec 26 - Dec 28

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Our top choices for Mark Twain hotels

Lobby
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch
4.0 star property
Downtown St. Louis, 8.4 km from Mark Twain
8.4 out of 10, Very Good, (4011)
"Everything was great!"
United States
Kathryn
The price is P4,942
P5,828 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Hyatt Regency St. Louis at The Arch
Bar (on property)
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
4.0 star property
Downtown St. Louis, 7.9 km from Mark Twain
8.8 out of 10, Excellent, (1157)
"Really nice hotel!"
United States
DARIN
The price is P4,691
P5,580 total
includes taxes & fees
Dec 23 - Dec 24
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Rooftop terrace
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch
3.0 star property
Downtown St. Louis, 8.4 km from Mark Twain
9.4 out of 10, Exceptional, (3289)
"Our stay was very enjoyable. Location was great and kids loved the indoor pool!"
United States
Christy
The price is P7,906
P9,245 total
includes taxes & fees
Dec 23 - Dec 24
Drury Plaza Hotel St. Louis at the Arch
Exterior
Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown
4.0 star property
Downtown St. Louis, 7.8 km from Mark Twain
8.8 out of 10, Excellent, (1245)
"Great hospitality"
United States
Alejandro
The price is P6,436
P7,654 total
includes taxes & fees
Dec 27 - Dec 28
Embassy Suites by Hilton St. Louis Downtown
Restaurant
Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL
3.0 star property
29.9 km from Mark Twain
9.6 out of 10, Exceptional, (1000)
"Excellent location, clean and spacious room, great morning breakfast with numerous choices and of course helpful and pleasant staff."
United States
David
The price is P5,989
P6,946 total
includes taxes & fees
Dec 28 - Dec 29
Drury Inn & Suites St. Louis O'Fallon, IL
Indoor pool, open 6:00 AM to 10:00 PM, sun loungers
Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Hampton Inn St. Louis-Downtown (At the Gateway Arch)
2.5 star property
Downtown St. Louis, 8.1 km from Mark Twain
8.8 out of 10, Excellent, (1175)
"Breakfast was great and this was my seventh year staying there."
United States
Derick
The price is P5,715
P6,683 total
includes taxes & fees
Dec 27 - Dec 28
Hampton Inn St. Louis-Downtown (At the Gateway Arch)
Exterior
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay
3.5 star property
9.4 km from Mark Twain
8.8 out of 10, Excellent, (3031)
"Clean room, good breakfast and good location "
United States
Martin
The price is P5,267
P6,148 total
includes taxes & fees
Dec 21 - Dec 22
Clayton Plaza Hotel & Extended Stay
Hypo-allergenic bedding, free WiFi, bed sheets
Tru By Hilton St. Louis Downtown

Tru By Hilton St. Louis Downtown

Tru By Hilton St. Louis Downtown
2.5 star property
Downtown West, 7.4 km from Mark Twain
7.6 out of 10, Good, (592)
"Breakfast was delicious and room was comfy "
United States
Ronnesha
The price is P4,755
P5,560 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Tru By Hilton St. Louis Downtown
Exterior
Holiday Inn Express Troy by IHG

Holiday Inn Express Troy by IHG

Holiday Inn Express Troy by IHG
2.5 star property
28.8 km from Mark Twain
9.4 out of 10, Exceptional, (704)
"Great breakfast ! "
United States
Jeanette
The price is P5,461
P6,061 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Holiday Inn Express Troy by IHG
Daily cooked-to-order breakfast for a fee
River City Casino & Hotel

River City Casino & Hotel

River City Casino & Hotel
4.0 star property
17.8 km from Mark Twain
9.0 out of 10, Wonderful, (1449)
"Awesome place to stay!!"
United States
Kaitlyn
The price is P5,798
P7,601 total
includes taxes & fees
Dec 24 - Dec 25
River City Casino & Hotel
Lobby sitting area
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
25.5 km from Mark Twain
8.0 out of 10, Very Good, (1042)
"Everything was clean and friendly staff overall good experience "
United States
dennis
The price is P4,978
P5,750 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Lobby
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport
2.5 star property
12.6 km from Mark Twain
9.4 out of 10, Exceptional, (2745)
"Great place to stay before your early morning flight. "
United States
Henry
The price is P5,271
P6,205 total
includes taxes & fees
Dec 23 - Dec 24
Pear Tree Inn St. Louis Airport
Exterior
Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield
3.0 star property
28.1 km from Mark Twain
9.6 out of 10, Exceptional, (1036)
"Absolutely amazing stay very nice play our family stays there every time very kid friendly"
United States
Matthew
The price is P7,614
P8,831 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Drury Plaza Hotel St. Louis Chesterfield
Free daily buffet breakfast
Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
23.2 km from Mark Twain
9.4 out of 10, Exceptional, (1001)
"Good stay."
United States
Steven
The price is P6,554
P7,532 total
includes taxes & fees
Dec 28 - Dec 29
Country Inn & Suites by Radisson, St. Charles Historic District
Lobby
Pear Tree Inn St. Louis Convention Center

Pear Tree Inn St. Louis Convention Center

Pear Tree Inn St. Louis Convention Center
3.0 star property
Downtown St. Louis, 7.9 km from Mark Twain
9.0 out of 10, Wonderful, (1053)
"It was perfect for our stay in St. Louis to visit the arch."
United States
Jacob
The price is P5,505
P6,437 total
includes taxes & fees
Dec 25 - Dec 26
Pear Tree Inn St. Louis Convention Center
Exterior
Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
29.9 km from Mark Twain
8.0 out of 10, Very Good, (1000)
"Good place to stay with pets"
United States
David
The price is P5,235
P6,016 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Hampton Inn St. Charles St. Peters
Living room
Courtyard by Marriott St. Louis Downtown/Convention Center

Courtyard by Marriott St. Louis Downtown/Convention Center

Courtyard by Marriott St. Louis Downtown/Convention Center
3.0 star property
Downtown St. Louis, 7.7 km from Mark Twain
9.0 out of 10, Wonderful, (1010)
"Was a great stay. "
United States
Lorilyn
The price is P5,924
P7,046 total
includes taxes & fees
Dec 27 - Dec 28
Courtyard by Marriott St. Louis Downtown/Convention Center
Courtyard
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
3.0 star property
20.5 km from Mark Twain
7.4 out of 10, Good, (1000)
"Clean lobby, super friendly staff, effortless check in. There’s even a small market with food and essentials right next to the check in desk. "
United States
Jen
The price is P4,175
P4,842 total
includes taxes & fees
Jan 15 - Jan 16, 2026
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Exterior
The Principal Hotel

The Principal Hotel

The Principal Hotel
3.5 star property
27.7 km from Mark Twain
9.8 out of 10, Exceptional, (191)
"Great place. Very nice rooms, new and clean."
United States
Jeff
The price is P6,607
P7,333 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The Principal Hotel
Exterior
Moonrise Hotel

Moonrise Hotel

Moonrise Hotel
4.0 star property
6.3 km from Mark Twain
9.0 out of 10, Wonderful, (1914)
"Clean rooms, good coffee and fresh muffins and friendly service."
United States
Colleen
The price is P6,912
P8,220 total
includes taxes & fees
Dec 24 - Dec 25
Moonrise Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Mark Twain

Find the best Mark Twain areas and neighborhoods for the activities you enjoy most.

Downtown St. Louis

Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Gateway Arch or Gateway Arch National Park might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.

Clayton

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

St. Charles Historic District

St. Charles Historic District is known for its abundant dining options, and you can plan a trip to Historic Main Street and Missouri River while you're in town.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Saint Louis Abbey while you're in town.

Central West End which includes heritage elements

Central West End

Enjoy this relaxed area, the ultimate destination for a lazy afternoon. Browse unique stores, admire artworks and sip coffee at sidewalk tables shaded by trees.

Top Mark Twain Hotel Reviews

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

10/10 Excellent
"All is perfect except room cleanse "
BINIAM 3-night trip
Posted 1 day ago
Drury Plaza Hotel St. Louis at the Arch

Frequently asked questions

What's it like in Mark Twain?
Travelers will be sure to find plenty to entertain them in St. Louis's Mark Twain neighborhood.
If I need to cancel my hotel reservation in Mark Twain, will I receive a refund?
Yes, you'll find most room reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Add your dates and click on "Search", then use the filter option "fully refundable" to get the best deals available in Mark Twain.
What is there to do around this St. Louis neighborhood?
Bellefontaine Cemetery, Calvary Cemetery, and Julia Davis Branch Library are just a few of the places to visit in and around Mark Twain. Shelley House and The Ville Monument are also worth a visit when you're out sightseeing in St. Louis.