Isle of Palms Trips (flight + hotel)

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Where to stay in Isle of Palms

Find the best Isle of Palms areas and neighborhoods for the activities you enjoy most. Learn more about Isle of Palms
Downtown Jacksonville showing a river or creek, skyline and a city

Downtown Jacksonville

1 out of top 10 points of interest in this area

Enjoy the stunning river views in Downtown Jacksonville. TIAA Bank Field is a worthwhile stop, and you can jump on the metro at Riverplace Station or Kings Avenue Station to see more of Jacksonville.

Find hotel + flight trips in Downtown Jacksonville

Top hotels in Isle of Palms

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3 out of 5
4905 SAN PABLO ROAD SOUTH, Jacksonville, FL
Fully refundableReserve now, pay when you stay
The price is P9,000 per night from 16 Jun to 17 Jun
P9,000
per night
16 Jun - 17 Jun
9.2/10 Wonderful! (257 reviews)
"Cleanliness and transportation to and from the Mayo Clinic"

Reviewed on May 7, 2024

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Margaritaville Jacksonville Beach
Margaritaville Jacksonville Beach
2.5 out of 5
715 1st St N, Jacksonville Beach, FL
Fully refundableReserve now, pay when you stay
The price is P10,393 per night from 27 May to 28 May
P10,393
per night
27 May - 28 May
8.8/10 Excellent! (2,422 reviews)
Last minute Solo Trip
"The hotel and room was amazing. The people amd service was great. If you want entertainment you must go outside the hotel. There is only one place to eat and not much of a breakfast selection."

Reviewed on May 20, 2024

Margaritaville Jacksonville Beach
Hampton Inn Jacksonville Beach/Oceanfront
Hampton Inn Jacksonville Beach/Oceanfront
3 out of 5
1515 1st St N, Jacksonville Beach, FL
Fully refundableReserve now, pay when you stay
The price is P9,824 per night from 30 May to 31 May
P9,824
per night
30 May - 31 May
9/10 Wonderful! (1,484 reviews)
"Beautiful beach. Room was ok. Comfortable. Would come back."

Reviewed on May 20, 2024

Hampton Inn Jacksonville Beach/Oceanfront
See all 3,230 properties in Isle of Palms
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Isle of Palms vacation package cost?
Starting from as low as , you can build your own Isle of Palms vacation package. Simply bundle flights, hotels and car rentals and be rewarded with discounts.
How do I get a cheap travel package to Isle of Palms?
If you love getting a great deal, bundle your bookings into an Isle of Palms vacation package. Whether you need hotels, flights, day tours or rental cars, you can book them all in one place. You’ll have ample choice at your fingertips too. Expedia has over 550 air carriers and 1,000,000 hotels all over the world to take your pick of. Fly with who you prefer, stay wherever you like and save precious money — now that’s the ideal escape!
Where should I stay in Isle of Palms?
Make sightseeing a breeze by staying someplace right around the corner from Isle of Palms’s big attractions. St. Johns Town Center and University of North Florida are two traveler favorites.
What are the top hotels in Isle of Palms?
Get your trip off to a great start by locking in a room at The Retreat Close To Mayo Clinic. It’s one of most sought-after hotels in Isle of Palms. Another top option is Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How far in advance should I book my Isle of Palms vacation?
Your best bet is to book early. Airlines usually advertise flights nearly 12 months prior to departure, and this is a perfect opportunity to land some of the lowest prices. Boss just told you to take your vacation time next week? No sweat. Expedia are never short on fantastic deals to whisk you away on the getaway of your dreams, at a price you can afford.
What does an Expedia Isle of Palms travel package include?
From hotels and flights to car rentals, Expedia can help you shape an Isle of Palms package that’s perfect for you. Vacationing for a while? Look into a rental car, flight and hotel bundle. If you can only squeeze in a quick getaway, a hotel and airfare deal could suit you better. Experiences can also be added once you’ve made your booking. Our vacation packages make it a breeze to save and plan.
What should I know before booking an Isle of Palms travel package?
A travel package can be easier on the hip pocket than individually booking everything you need for your adventure. For example, bundle your hotels, flights and rental cars and save a pretty penny. Whatever sort of vacation you’re planning, there’s sure to be a package that matches your budget.
Can I choose my airline with an Isle of Palms Expedia vacation package?
Yes, the choice is all yours. We have access to over 550 partner airlines throughout the world, so you can design your Isle of Palms trip according to your travel needs.
If I'm not able to travel, can I cancel my Isle of Palms vacation package?
Because we understand life is full of surprises, the answer is yes. To find out more, check out our Customer Service Portal. But generally speaking, if you’ve booked your package in the last 24 hours, you may be able to cancel or change it with no penalties. Your airline, hotel or car rental company may charge a fee if your booking is older than that.

Popular places to visit

Image for Mayo Clinic Florida

Mayo Clinic Florida

Though Mayo Clinic Florida might be what brings you to town, perhaps you'll have a chance to explore more of Jacksonville while you are here.

Mayo Clinic Florida
Image for Jacksonville Naval Air Station

Jacksonville Naval Air Station

After visiting Jacksonville Naval Air Station, make a plan to see the other sights and activities in Jacksonville. Experience the great live music or attend a sporting event in this family-friendly area.

Jacksonville Naval Air Station
Image for EverBank Stadium

EverBank Stadium

Capable of seating over 80,000 fans, this modern football stadium is the exciting home of the Jacksonville Jaguars, international soccer games and music events.

EverBank Stadium

Things to do

Image for Self-Guided Kayaking: Real Florida Adventure

Self-Guided Kayaking: Real Florida Adventure

P2,490
Per adult
100% of travellers recommend
Self-Guided Kayaking: Real Florida Adventure
See all activities in Jacksonville

More trip options

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.