South Central Houston
Houston
Visit South Central Houston
Popular places to visit
MD Anderson Cancer Center
Though MD Anderson Cancer Center might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Rice University
Enjoy the collegiate vibe when you visit Rice University, during your travels in Houston. Experience the area's lively festivals and fascinating museums.
Houston Zoo
With a huge collection of animals, a water park and a cinema, Houston Zoo is a great day out for the family.
University of Houston
Enjoy the collegiate vibe when you visit University of Houston, during your travels in Houston. Experience the great live music and lively festivals in this vibrant area.
Children's Museum of Houston
You can take time to visit Children's Museum of Houston during your travels to Houston. Experience the area's entertainment choices and acclaimed theater scene.
Houston Natural Science Museum
You can spend time studying the exhibits at Houston Natural Science Museum in Houston. Experience the area's great live music and acclaimed theater scene.
Things to do
Houston's Official City & Mural Tour!
Houston Museum of Natural Sciences: Planetarium Ticket
Houston: Houston Botanic Garden Entry Ticket
Astroville Tunnel Tour of Downtown Houston (Air-Conditioned)
From Houston: Crocodile Encounter Entry Ticket
Houston: Museum of Natural Science General Admission Ticket
Top hotels in South Central Houston
Hotel Zaza Houston Museum District
Great property!
Reviewed on Apr 2, 2026
Hilton Houston Plaza/Medical Center
InterContinental Houston by IHG
Everyone is always friendly as usual!
Reviewed on Mar 27, 2026
The Westin Houston Medical Center/Museum District
Wonderful place, highly recommended
Reviewed on Apr 3, 2026
Americas Best Value Inn Medical Center Downtown
Horrible waiting on my money back
Reviewed on Apr 2, 2026
DoubleTree by Hilton Houston Medical Center Hotel & Suites
Just use the room for sleeping. The bed was a little firmer than I prefer
Reviewed on Apr 3, 2026
Other neighbourhoods around South Central Houston
Greater Third Ward
While you're in Greater Third Ward, take in top sights like Barbara Jordan & Mickey Leland Archives or Fertitta Center, and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Midtown
The restaurants and live music are just a few things visitors like about Midtown. Houston Fire Museum and Midtown Arts and Theater Center Houston are worthwhile spots to check out, and you can hop on the metro at McGowen Station or Ensemble/HCC Station to get around the larger area.
East Downtown Houston
Get to know East Downtown Houston and its many features like its restaurants and live music. You might want to explore sights like Shell Energy Stadium and Giant Beatles Statues, and you can jump on the metro at Leeland/Third Ward Station or EaDo/Stadium Station to get around the city.
Museum District
Known for its ample dining options and fascinating museums, there's plenty to explore in Museum District. You can visit top attractions like Children's Museum of Houston and Houston Natural Science Museum, and jump on the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
Downtown Houston
Known for its abundant dining options and live music, there's plenty to explore in Downtown Houston. Top attractions like Toyota Center and Daikin Park are major draws, and you can catch the metro at Central Station Main or Main Street Square Station to see more of the city.
