Hotels near Florida Keys National Marine Sanctuary

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Mar 5 - Mar 6
Tomorrow
Mar 6 - Mar 7
This weekend
Mar 6 - Mar 8
Next weekend
Mar 13 - Mar 15

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Florida Keys National Marine Sanctuary hotels

Free daily continental breakfast

Almond Tree Inn Hotel - Adults Only

Almond Tree Inn Hotel - Adults Only
3.5 star property
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
10.0 out of 10, Exceptional, (1,004 reviews)
"Excellent hotel in a great location just off Duval Street. The staff were very attentive, rooms clean. "
United Kingdom
Stephen
The price is P29,309
P32,973 total
includes taxes & fees
Apr 5 - Apr 6
Almond Tree Inn Hotel - Adults Only
Property grounds

Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only
3.5 star property
Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1,002 reviews)
"Clean room, great breakfast and nice staff"
United States
Tari
The price is P29,046
P32,677 total
includes taxes & fees
Apr 5 - Apr 6
Orchid Key Inn - Adults Only
Terrace/patio

The Mermaid & Alligator

The Mermaid & Alligator
3.5 star property
Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (288 reviews)
"Clean great staff wonderful breakfast"
United States
Kat
The Mermaid & Alligator
Exterior

Douglas House

Douglas House
3.0 star property
Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (304 reviews)
"Great place with a perfect location. "
United States
Brandon
The price is P13,851
P17,141 total
includes taxes & fees
Mar 10 - Mar 11
Douglas House
Courtyard

H2O Suites - Adults Only

H2O Suites - Adults Only
3.5 star property
Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (588 reviews)
"Great place!!"
United States
Joel
The price is P36,256
P44,742 total
includes taxes & fees
Apr 5 - Apr 6
H2O Suites - Adults Only
Sports facility

Tropical Inn

Tropical Inn
3.5 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (381 reviews)
"Nice place to stay "
United States
yulio
The price is P21,211
P25,327 total
includes taxes & fees
Mar 8 - Mar 9
Tropical Inn
Balcony view

Island City House Hotel

Island City House Hotel
3.0 star property
Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1,002 reviews)
"Excellent stay"
United States
Emily Barbara
The price is P21,295
P23,957 total
includes taxes & fees
Mar 16 - Mar 17
Island City House Hotel
Front of property

L'Habitation Guest House

L'Habitation Guest House
2.5 star property
Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (947 reviews)
"Great location "
United States
Scott
The price is P17,513
P19,702 total
includes taxes & fees
Apr 5 - Apr 6
L'Habitation Guest House
Courtyard

The Grand Guesthouse

The Grand Guesthouse
2.5 star property
Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1,003 reviews)
"Great location and really nice room. Def stay here again. "
United States
Daniel
The price is P19,214
P23,080 total
includes taxes & fees
Mar 12 - Mar 13
The Grand Guesthouse
Property grounds

Duval House

Duval House
3.0 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,006 reviews)
"Great place! "
United States
David
The price is P20,969
P24,849 total
includes taxes & fees
Mar 8 - Mar 9
Duval House
3 outdoor pools, a heated pool, sun loungers

Ambrosia Key West

Ambrosia Key West
3.5 star property
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,001 reviews)
"Great place to stay"
United States
Melody
The price is P18,355
P20,649 total
includes taxes & fees
Mar 8 - Mar 9
Ambrosia Key West
2 outdoor pools, sun loungers

Santa Maria Suites

Santa Maria Suites
4.0 star property
Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1,001 reviews)
"Great place to stay! Hope to come back!"
United States
Scott G.
The price is P45,519
P55,153 total
includes taxes & fees
Mar 11 - Mar 12
Santa Maria Suites
Front of property

Caribbean House

Caribbean House
3.0 star property
Bahama Village, 0.5 km from Florida Keys National Marine Sanctuary
9.2 out of 10, Wonderful, (328 reviews)
"Cute little place. "
United States
Wendy
The price is P17,622
P21,289 total
includes taxes & fees
Apr 1 - Apr 2
Caribbean House
Front of property - evening/night

Southernmost House

Southernmost House
4.0 star property
Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,005 reviews)
"Excellent location, friendly staff, great amenities. Very happy we stayed there!"
United States
Gregory
The price is P31,501
P42,834 total
includes taxes & fees
Mar 11 - Mar 12
Southernmost House
Property grounds

Paradise Inn Key West - Adults Only

Paradise Inn Key West - Adults Only
3.5 star property
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
9.2 out of 10, Wonderful, (1,006 reviews)
"Great location and very clean and quaint! Great front desk staff as well!"
United States
Krista
Paradise Inn Key West - Adults Only
View from room

Opal Key Resort & Marina, Key West

Opal Key Resort & Marina, Key West
4.0 star property
Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary
9.2 out of 10, Wonderful, (1,065 reviews)
"Awsome resort. Great food and staff"
United States
Doug
The price is P30,692
P36,835 total
includes taxes & fees
Apr 5 - Apr 6
Opal Key Resort & Marina, Key West
Outdoor pool

The Key West Hotel

The Key West Hotel
2.5 star property
Historic Seaport, 0.9 km from Florida Keys National Marine Sanctuary
9.2 out of 10, Wonderful, (534 reviews)
"Great location, very clean, and great staff"
United States
William
The price is P25,293
P31,676 total
includes taxes & fees
Mar 8 - Mar 9
The Key West Hotel
Exterior

The Garden House

The Garden House
3.0 star property
Historic Seaport, 1.1 km from Florida Keys National Marine Sanctuary
9.2 out of 10, Wonderful, (686 reviews)
"Room was spotless, breakfast by the pool is a plus, host is always attentive to making everything right!"
United States
Robert
The price is P20,266
P24,058 total
includes taxes & fees
Mar 8 - Mar 9
The Garden House
Front of property

Winslow's Bungalows - Key West Historic Inns

Winslow's Bungalows - Key West Historic Inns
4.0 star property
Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary
9.2 out of 10, Wonderful, (1,184 reviews)
"The atmosphere was perfect! "
United States
Sheila
The price is P27,459
P33,856 total
includes taxes & fees
Apr 5 - Apr 6
Winslow's Bungalows - Key West Historic Inns
Porch

Heron House - Adult Only

Heron House - Adult Only
3.5 star property
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
9.0 out of 10, Wonderful, (1,149 reviews)
"Loved our stay here! "
United States
Brianna
The price is P18,371
P22,941 total
includes taxes & fees
Mar 10 - Mar 11
Heron House - Adult Only
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Florida Keys National Marine Sanctuary Hotel Reviews

La Concha Key West, Autograph Collection

La Concha Key West, Autograph Collection

10/10 Excellent
"Location is excellent. No need to rent a golf cart. We were able to walk to almost everywhere. The staff were all wonderful. Extremely helpful, and so very nice and friendly - and I do mean all of them from the front desk clerk, to the food and beverage manager - could not have been nicer. The hotel is beautiful, and the complimentary rum punch every afternoon was something you won't get anywhere else that I know of. From now on this is our go-to accommodations in Key West!"
Pamela 2-night trip
Posted 6 hours ago
La Concha Key West, Autograph Collection

Hotels near other Florida Keys National Marine Sanctuary attractions

Florida Keys Eco - Discovery Center which includes interior views

Florida Keys Eco - Discovery Center

4.3/5 (128 reviews)
Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.
See properties
Fort Zachary Taylor Park, Key West. State Park in Florida, USA., Shutterstock ID 761867707, Purchase Order: SP-1891 Wave 0, Client/Licensee: Hotels.com

Fort Zachary Taylor Historic State Park

4.4/5 (1,160 reviews)
The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.
See properties

Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?
Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1546 hotels and other accommodations you'll find within a mile.
Where is the best place to stay close to Florida Keys National Marine Sanctuary?
Adjacent to Florida Keys National Marine Sanctuary, Caribbean House is one of the top choices for your stay based on our traveler data, and this B&B offers free breakfast and private balconies. Other good choices close by include Southernmost Beach Resort and Guesthouses and Hyatt Centric Key West Resort and Spa.
How many hotels will I be able to find near Florida Keys National Marine Sanctuary?
Expedia has 1546 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.
If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?
Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.
What can I see and do near Florida Keys National Marine Sanctuary?
Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Waterfront Playhouse, Key West Film Society, and Red Barn Theater if you're interested in local theater.