Business Hotels in Florida Keys, United States of America

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Check availability on Florida Keys Business Hotels

Tonight
Dec 21 - Dec 22
Tomorrow
Dec 22 - Dec 23
Next weekend
Dec 26 - Dec 28
In two weeks
Jan 2 - Jan 4

Our top choices for Florida Keys business-friendly hotels

Exterior
Lime Tree Bay Resort

Lime Tree Bay Resort

Lime Tree Bay Resort
3.5 star property
Long Key
9.2 out of 10, Wonderful, (1107)
"Great place "
United States
Oscar
Lime Tree Bay Resort
Aerial view
Dove Creek Resort & Marina, Trademark Collection by Wyndham

Dove Creek Resort & Marina, Trademark Collection by Wyndham

Dove Creek Resort & Marina, Trademark Collection by Wyndham
3.0 star property
Key Largo
7.6 out of 10, Good, (1001)
"The rooms are lovely. Once the remodel is done the place will be perfect. "
United States
Deborah
The price is P8,486
P11,409 total
includes taxes & fees
Jan 21 - Jan 22, 2026
Dove Creek Resort & Marina, Trademark Collection by Wyndham
Terrace/patio
Bayside Inn Key Largo

Bayside Inn Key Largo

Bayside Inn Key Largo
3.0 star property
Key Largo
8.6 out of 10, Excellent, (1627)
"Friendly staff, clean room beautiful views from the private beach."
United States
Wanda
The price is P9,630
P12,302 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Bayside Inn Key Largo
Property amenity
Fairfield Inn & Suites by Marriott Marathon Florida Keys

Fairfield Inn & Suites by Marriott Marathon Florida Keys

Fairfield Inn & Suites by Marriott Marathon Florida Keys
2.5 star property
Marathon
9.2 out of 10, Wonderful, (1049)
"Great staff, clean room, good breakfast "
United States
Kelly
The price is P12,860
P14,468 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Fairfield Inn & Suites by Marriott Marathon Florida Keys
Beach/ocean view
Hampton Inn Key Largo Manatee Bay

Hampton Inn Key Largo Manatee Bay

Hampton Inn Key Largo Manatee Bay
2.5 star property
Key Largo
8.8 out of 10, Excellent, (1005)
"Clean hotel, convenient location. Nice little beach area with tiki bar. Room was nice. "
Canada
Troy
The price is P9,663
P10,871 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hampton Inn Key Largo Manatee Bay
Marina
Skipjack Resort & Marina

Skipjack Resort & Marina

Skipjack Resort & Marina
3.0 star property
Marathon
8.6 out of 10, Excellent, (1217)
"Beautiful location clean rooms friendly staff "
United States
Tiffany
Skipjack Resort & Marina
Exterior
Islander Resort

Islander Resort

Islander Resort
4.0 star property
Matecumbe
9.2 out of 10, Wonderful, (1002)
"The resort was perfect Everyone from checking in and during our stay could not have been nicer and helpful"
United States
Theresa
The price is P16,442
P22,461 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Islander Resort
Front of property
Siesta Motel

Siesta Motel

Siesta Motel
2.0 star property
Marathon
7.4 out of 10, Good, (693)
"Excellent motel for visiting nearby marina. A/C did fine even at 92F outdoors. "
United States
Maggie
The price is P10,702
P12,040 total
includes taxes & fees
Dec 23 - Dec 24
Siesta Motel
4 outdoor pools, pool umbrellas, sun loungers
Parrot Key Hotel & Villas

Parrot Key Hotel & Villas

Parrot Key Hotel & Villas
4.0 star property
Northside Resort
9.0 out of 10, Wonderful, (1201)
"Great place to stay 👌 👍 "
United States
james
The price is P11,430
P16,228 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Parrot Key Hotel & Villas
Property grounds
Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa
5.0 star property
Marathon
9.2 out of 10, Wonderful, (1072)
"Beautiful property, staff are very friendly "
United States
Leann
The price is P18,973
P25,090 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Isla Bella Beach Resort & Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Florida Keys Hotel Reviews

Marina Del Mar Resort and Marina

Marina Del Mar Resort and Marina

10/10 Excellent
"Room clean, beautiful setting, pleasant ambiance good restaurants! Staff friendly and courteous"
Linda 2-night trip
Posted 4 days ago
Marina Del Mar Resort and Marina

Frequently asked questions

How much do business-friendly hotels in Florida Keys cost?
Prices for business hotels in Florida Keys range between P10,871 and P25,090 per night. No matter your budget, Expedia can help you locate the ideal space to get your work done. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Florida Keys?
Florida Keys has multiple business-friendly hotels with a total average guest review rating of 8.6. Attending a work-related event in Key West? The Perry Hotel & Marina Key West is a 4-stars stay that comes highly recommended by corporate travelers and includes a nearby waterfront and a garden. Another excellent pick for an official business trip is Silver Palms Inn. Also in Key West, it has a 3.5-stars rating and conveniences such as an electric car charging station and a swimming pool.
How many business-friendly hotels are there in Florida Keys?
Florida Keys has 87 business-friendly hotels to pick from. Whether you're attending a conference or meeting or working remotely, these stays are equipped with the amenities you need to be productive.
What are the best cheap business-friendly hotels in Florida Keys?
That depends on which part of Florida Keys your working visit is taking you. If you're traveling to Key West, Best Western Hibiscus Motel meets the needs of business travelers at an affordable price. A spa tub and a restaurant are among its many conveniences. Meeting with clients in Key Largo? Check in to Coconut Palm Inn. Pool sun loungers and a garden help make this inexpensive property a favorite with corporate guests. Business-friendly hotels start from just P10,871 a night, so your work trip doesn't have to be costly. Want to explore Florida Keys without blowing your budget? Take a break from your business events to visit cool free attractions like Smathers Beach in Key West. Key Largo also has plenty of things to do that won't cost a penny, including Baker's Cay Resort Beach. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Are there any family-friendly hotels in Florida Keys that are also business friendly?
If you're traveling for business in Florida Keys and bringing your family along with you, Expedia will help you find a suitable stay. Eden House in Key West is an ideal option for those juggling work and pleasure. This 3.5-stars property offers all the necessary amenities, like a sauna and a cafe. Hyatt Centric Key West Resort and Spa is another good choice in Key West. Combine corporate travel and quality time with your family at this 4-stars property. A nearby beach and WiFi are two of the many conveniences you'll find here. There are plenty of terrific things to do for the whole family in Key West. Smathers Beach and South Beach promise a great day out.
Are there any 5-star business-friendly hotels in Florida Keys?
While there aren't any 5-star business-friendly hotels in Florida Keys, there are still chic properties to choose from. Work taking you to Key West? The Perry Hotel & Marina Key West is a popular option that has everything you need while you're away from home on business. Amenities at this 4-star property include pillow top mattresses and designer toiletries. Ocean Key Resort - A Noble House Resort is another recommendation that caters to corporate travelers in Key West. Also rated 4 stars and featuring a swimming pool and a resort, you'll find plenty to love about this hotel.
Why book your business-friendly hotel in Florida Keys with Expedia?
Here at Expedia, our top task is to help you land a suitable stay at the right price. From deluxe, corporate-friendly getaways to affordable motels filled with all the amenities you need, you'll have your next work trip planned in a few quick clicks.
How can I find cheap business-friendly hotels in Florida Keys?
When work takes you on the road in Florida Keys, our "business friendly" filter will help you find the ideal hotel. From included breakfast and free WiFi to concierge services and conference spaces, they come with the amenities you need to be productive. You can also refine your search by your budget and preferred star rating to see the cheapest properties.
What is there to do in Florida Keys near my business-friendly hotel?
Whether you like shopping, dining, history or culture, Florida Keys is one place you'll never get bored! The well-known city of Key West has tons of attractions, including Smathers Beach, South Beach and Clarence S. Higgs Memorial Beach Park. If you're planning a work trip to Key Largo, Baker's Cay Resort Beach, Jimmy Johnson's Big Chill and Bluefin Rock Harbor Marina are worth putting on your itinerary.

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