Eastern Panama 4 Stars Hotels

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Eastern Panama 4 Star Hotels

Tonight
Aug 2 - Aug 3
Tomorrow
Aug 3 - Aug 4
Next weekend
Aug 8 - Aug 10
In two weeks
Aug 15 - Aug 17

Top Eastern Panama 4 Stars Hotels

Ordovician Beach Resort
1 bedroom, Egyptian cotton sheets, premium bedding, pillowtop beds

Ordovician Beach Resort

4.5 star property
10.0 out of 10, Exceptional, (2)
"The Ordovician Hotel is a hidden gem on the peaceful west side of Isla Grande. From the moment we booked, the service was personal and seamless—thank you, Yohan! We were welcomed by name, greeted with a delicious tropical drink, and felt like cherished guests from start to finish. We stayed in the Peacock Room, which had stunning views of the pool, restaurant, and beach. The room was beautifully curated, with luxurious bedding, high-end amenities, and thoughtful touches like a handwritten...
Ordovician Beach Resort
Mandalas Ecolodge
Exterior

Mandalas Ecolodge

4.0 star property
Mandalas Ecolodge
El Otro Lado
Outdoor pool

El Otro Lado

4.0 star property
9.8 out of 10, Exceptional, (8)
"Amazing.. Amazing. You need extra words, We loved it. We loved it.Amazing.. Amazing. You need extra words, We loved it. We loved it. Amazing.. Amazing. You need extra words, We loved it. We loved it. "
El Otro Lado
Portobello Historico
Premium bedding, down comforters, individually decorated

Portobello Historico

4.0 star property
Portobello Historico
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about Eastern Panama

Explore attractions like Cayos Holandeses and Chagres National Park as you discover things to see and do in Eastern Panama.

See all hotels in Eastern Panama

Top Eastern Panama Hotel Reviews

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Eastern Panama?
With Expedia's handy filter tool, scoring an awesome deal on a 4-star hotel in Eastern Panama just got simpler. Start by keying in your chosen arrival date and length of your vacation. Then sort the results by price and pick the option that best matches your budget and style.

  • Search for the lowest price

What's the difference between 5-star and 4-star hotels in Eastern Panama?
If you decide to book a stay at a 4-star hotel in Eastern Panama, you'll usually find lots of conveniences to keep you comfortable, such as a pool, restaurant and gym. You can experience top-quality service and upscale accommodations. Go for a 5-star hotel and you'll have access to a few more bells and whistles — think on-site spas, concierge assistance and nightly turndown services. You'll most likely get extra amenities and premium services at a 5-star retreat, but both are terrific options for luxury guests.
Does Eastern Panama have any 4-star all-inclusive resorts?
Use our "All inclusive" filter to find your next getaway in Eastern Panama where just about everything is taken care of, from your meals to your accommodations, activities and entertainment. We can also help you find standard 4-star stays in and around this leading destination.