Photo by Dean Moore

Hotels near St. Lucie Medical Center

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for St. Lucie Medical Center hotels

Holiday Inn Port St. Lucie by IHG

Holiday Inn Port St. Lucie by IHG
3.0 star property
Sandhill Crossing, 1 km from St. Lucie Medical Center
6.8 out of 10, (1001)
"The room was spot less and the staff was very helpful."
United States
Edward
The price is P6,179
P6,920 total
includes taxes & fees
Dec 30 - Dec 31
Holiday Inn Port St. Lucie by IHG

Best Western Port St. Lucie

Best Western Port St. Lucie
2.5 star property
4.3 km from St. Lucie Medical Center
8.6 out of 10, Excellent, (1002)
"Love this place. Great place with a lot of space."
United States
Bradley
The price is P5,884
P6,590 total
includes taxes & fees
Dec 28 - Dec 29
Best Western Port St. Lucie

Home2 Suites by Hilton Stuart

Home2 Suites by Hilton Stuart
3.0 star property
7.9 km from St. Lucie Medical Center
9.4 out of 10, Exceptional, (607)
"Love staying here. The staff are wonderful, the rooms are clean and the breakfast is decent with lots of options. "
United States
Heather
The price is P7,672
P8,555 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Home2 Suites by Hilton Stuart

Hampton Inn & Suites Stuart-North

Hampton Inn & Suites Stuart-North
2.5 star property
8.3 km from St. Lucie Medical Center
8.8 out of 10, Excellent, (1002)
"Staff warm and friendly and helpful with local spots to visit! "
United States
CHRISTY
The price is P7,672
P8,555 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hampton Inn & Suites Stuart-North

Old Colorado Inn

Old Colorado Inn
3.5 star property
10.7 km from St. Lucie Medical Center
9.8 out of 10, Exceptional, (679)
"Perfect location. Quaint place to stay."
United States
Stephen
Old Colorado Inn

The Lucie

The Lucie
3.0 star property
9.5 km from St. Lucie Medical Center
9.0 out of 10, Wonderful, (1002)
"Great stay, excellent staff. "
United States
Steve
The price is P10,133
P13,656 total
includes taxes & fees
Jan 1 - Jan 2, 2026
The Lucie

Hutchinson Shores Resort & Spa

Hutchinson Shores Resort & Spa
4.0 star property
10.7 km from St. Lucie Medical Center
9.4 out of 10, Exceptional, (1000)
"Room was clean and comfortable, staff was very kind and helpful, I will definitely visit again "
United States
Andrekiss
The price is P14,014
P18,262 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hutchinson Shores Resort & Spa

Residence Inn by Marriott Port St. Lucie

Residence Inn by Marriott Port St. Lucie
3.0 star property
11.7 km from St. Lucie Medical Center
9.2 out of 10, Wonderful, (1001)
"Great stay! Very friendly staff "
United States
Giovanni
The price is P7,179
P8,041 total
includes taxes & fees
Dec 28 - Dec 29
Residence Inn by Marriott Port St. Lucie

Vistana Beach Club

Vistana Beach Club
3.5 star property
9.2 km from St. Lucie Medical Center
9.2 out of 10, Wonderful, (119)
"VERY NICE"
United States
Rikke
The price is P13,593
P15,225 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Vistana Beach Club

SpringHill Suites Port St. Lucie

SpringHill Suites Port St. Lucie
3.0 star property
Saint Lucie West, 11.8 km from St. Lucie Medical Center
8.6 out of 10, Excellent, (1001)
"Great stay"
United States
Craig
The price is P5,826
P6,525 total
includes taxes & fees
Dec 29 - Dec 30
SpringHill Suites Port St. Lucie

Tru by Hilton Port St. Lucie Tradition

Tru by Hilton Port St. Lucie Tradition
2.5 star property
Traditions, 13.6 km from St. Lucie Medical Center
9.2 out of 10, Wonderful, (760)
" I’ve stayed twice and it’s been an excellent experience. Clean facilities and great staff. "
United States
Daniel
The price is P5,509
P6,170 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Tru by Hilton Port St. Lucie Tradition

Days Inn & Suites by Wyndham Fort Pierce Midtown

Days Inn & Suites by Wyndham Fort Pierce Midtown
2.0 star property
13.6 km from St. Lucie Medical Center
6.8 out of 10, (1001)
"Location was good"
United States
Chokri
The price is P4,252
P4,762 total
includes taxes & fees
Dec 27 - Dec 28
Days Inn & Suites by Wyndham Fort Pierce Midtown

Best Western Downtown Stuart

Best Western Downtown Stuart
3.0 star property
12.1 km from St. Lucie Medical Center
8.6 out of 10, Excellent, (1001)
"Nice hotel for the money"
United States
Rosemary
The price is P7,388
P8,274 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Best Western Downtown Stuart

Hampton Inn & Suites Port St. Lucie, West

Hampton Inn & Suites Port St. Lucie, West
2.5 star property
11.4 km from St. Lucie Medical Center
8.8 out of 10, Excellent, (1005)
"Amazing stay. "
United States
Florim
The price is P6,118
P6,852 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hampton Inn & Suites Port St. Lucie, West

TownePlace Suites by Marriott Port St. Lucie I-95

TownePlace Suites by Marriott Port St. Lucie I-95
3.0 star property
Traditions, 13.5 km from St. Lucie Medical Center
9.4 out of 10, Exceptional, (1000)
"Room was clean, friendly staff and good complimentary breakfast"
United States
REX
The price is P7,362
P8,245 total
includes taxes & fees
Dec 29 - Dec 30
TownePlace Suites by Marriott Port St. Lucie I-95

Courtyard by Marriott Port St. Lucie Tradition

Courtyard by Marriott Port St. Lucie Tradition
3.0 star property
Traditions, 13.6 km from St. Lucie Medical Center
9.4 out of 10, Exceptional, (487)
"Clean & comfortable!"
United States
Tammy
The price is P8,180
P9,161 total
includes taxes & fees
Dec 28 - Dec 29
Courtyard by Marriott Port St. Lucie Tradition

Holiday Inn Express & Suites Port St. Lucie West by IHG

Holiday Inn Express & Suites Port St. Lucie West by IHG
2.5 star property
Saint Lucie West, 11.7 km from St. Lucie Medical Center
8.6 out of 10, Excellent, (1000)
"Clean room, quite, good breakfast made for a nice stay"
United States
Ronald
The price is P6,297
P7,052 total
includes taxes & fees
Dec 29 - Dec 30
Holiday Inn Express & Suites Port St. Lucie West by IHG

Mainstay Suites at PGA Village

Mainstay Suites at PGA Village
2.5 star property
12.9 km from St. Lucie Medical Center
6.4 out of 10, (825)
"Everything was good"
United States
LIDIA
The price is P3,940
P4,413 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Mainstay Suites at PGA Village

Hilton Garden Inn at PGA Village / Port St. Lucie

Hilton Garden Inn at PGA Village / Port St. Lucie
3.0 star property
12.8 km from St. Lucie Medical Center
8.8 out of 10, Excellent, (1000)
"The room was very clean and the staff was friendly and helpful"
United States
Alan
The price is P6,984
P7,822 total
includes taxes & fees
Dec 28 - Dec 29
Hilton Garden Inn at PGA Village / Port St. Lucie

Sleep Inn Port St. Lucie at PGA Village

Sleep Inn Port St. Lucie at PGA Village
2.5 star property
12.9 km from St. Lucie Medical Center
6.4 out of 10, (369)
"very limited breakfast"
United States
Jerzy
The price is P4,428
P4,960 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Sleep Inn Port St. Lucie at PGA Village
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top St. Lucie Medical Center Hotel Reviews

Hotels near other St. Lucie Medical Center attractions

Frequently asked questions

What's the area like around St. Lucie Medical Center?
St. Lucie Medical Center is located in Port Saint Lucie. If you're looking for a convenient place to stay, check out the 20 hotels and other accommodations you'll find within a mile.
What's the best place to stay close to St. Lucie Medical Center?
Holiday Inn Port St. Lucie by IHG is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. It's located just a short 0.6 mi (1 km) from St. Lucie Medical Center. Another good option is Best Western Port St. Lucie, located 2.7 mi (4.3 km) away.
How many hotels are there close to St. Lucie Medical Center?
Expedia has 20 hotels and other accommodations within a mile from St. Lucie Medical Center.
If I need to cancel the hotel reservation for my stay near St. Lucie Medical Center, will I receive a refund?
Yes, you'll find most hotel room reservations are refundable if you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to view the top deals on offer near St. Lucie Medical Center.
What can I see and do near St. Lucie Medical Center?
Local parks like Port St. Lucie Botanical Gardens, River Park Marina, and Veterans Memorial Park are peaceful spots to stop and take in some fresh air. Dip your toes in the water at Normandy Beach, Fort Pierce Beach, and Herman's Bay Beach. Spend some time exploring the great outdoors at Walton Scrub Preserve, Spruce Bluff Preserve, and Ocean Bay Beachside.