Photo by Southernmost Illinois Tourism Bureau

Hotels with Air Conditioning in Southern Illinois, Illinois

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Check availability on Southern Illinois Hotels with Air Conditioning

Tonight
Dec 25 - Dec 26
Tomorrow
Dec 26 - Dec 27
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

Our top choices for Southern Illinois hotels with air conditioning

Property entrance
Hampton Inn & Suites Effingham

Hampton Inn & Suites Effingham

Hampton Inn & Suites Effingham
2.5 star property
Effingham
9.6 out of 10, Exceptional, (683)
"The room was very clean, the staff was very friendly and helpful. We appreciated the wrapping station so much as we stayed the week of Christmas. "
United States
Angela
The price is P6,213
P6,895 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hampton Inn & Suites Effingham
Exterior
Holiday Inn Express & Suites Effingham by IHG

Holiday Inn Express & Suites Effingham by IHG

Holiday Inn Express & Suites Effingham by IHG
2.5 star property
Effingham
9.4 out of 10, Exceptional, (1000)
"Clean room, excellent staff."
United States
Nancy
The price is P6,108
P6,840 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Holiday Inn Express & Suites Effingham by IHG
Exterior
Drury Inn & Suites Marion

Drury Inn & Suites Marion

Drury Inn & Suites Marion
3.0 star property
Marion
9.4 out of 10, Exceptional, (1001)
"Hotel is very clean and staff is also friendly."
United States
Tonya
The price is P3,817
P4,580 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Drury Inn & Suites Marion
Terrace/patio
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

Comfort Suites Mount Vernon
2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1003)
"Check in was quick, staff was friendly and helpful, room was very nice and clean."
United States
Don
The price is P6,402
P7,222 total
includes taxes & fees
Dec 27 - Dec 28
Comfort Suites Mount Vernon
Desk, soundproofing, iron/ironing board, rollaway beds
Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL
2.5 star property
Effingham
8.8 out of 10, Excellent, (1002)
"Clean rooms and kind staff"
United States
Linda
The price is P5,242
P5,817 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Country Inn & Suites by Radisson, Effingham, IL
Lobby
La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham
3.0 star property
Effingham
9.2 out of 10, Wonderful, (1000)
"Clean, pleasant, fast check in, and warm pool! I have stayed here 2 times before and have already booked a room for my return trip here. Great place to stay!"
United States
Barbara
The price is P5,442
P6,093 total
includes taxes & fees
Jan 4 - Jan 5, 2026
La Quinta Inn & Suites by Wyndham Effingham
Lobby
Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
3.0 star property
Mount Vernon
9.6 out of 10, Exceptional, (1588)
"Great place to stay. Check in is easy and the hotel people are very nice."
United States
Duane
The price is P5,520
P6,244 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Drury Plaza Hotel Mt. Vernon
Iron/ironing board, free WiFi, bed sheets
Quality Inn & Suites Metropolis I-24

Quality Inn & Suites Metropolis I-24

Quality Inn & Suites Metropolis I-24
2.5 star property
Metropolis
8.0 out of 10, Very Good, (1000)
"Courteous staff, clean rooms. "
United States
Jennifer
The price is P3,224
P3,754 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Quality Inn & Suites Metropolis I-24
Free daily continental breakfast
Best Western Delta Inn

Best Western Delta Inn

Best Western Delta Inn
2.5 star property
Effingham
9.2 out of 10, Wonderful, (1001)
"Great breakfast!"
United States
Michele
The price is P4,942
P5,534 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Best Western Delta Inn
Lobby
SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake
2.5 star property
Whittington
8.8 out of 10, Excellent, (910)
"Great place to stay."
United States
Stephen
The price is P3,993
P4,432 total
includes taxes & fees
Dec 31 - Jan 1, 2026
SureStay Hotel by Best Western Whittington Rend Lake
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Southern Illinois Hotel Reviews

Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

10/10 Excellent
"Wonderful stay! Staff was kind, efficient, and informative. Having drinks, appetizers, and a full breakfast was a definite plus. The best night of rest in 2 weeks away from home, the bed was not a board! Definitely choosing Drury again over others!"
Dominique 1-night trip
Posted 2 days ago
Drury Inn & Suites St. Louis Fairview Heights

Frequently asked questions

How much do hotels with air conditioning in Southern Illinois cost?
Prepare to pay between P3,754 and P7,222 per night for hotels with air conditioning in Southern Illinois. Whatever your travel plans and budget, your ideal stay is only a click away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best hotels with air conditioning in Southern Illinois?
Glide straight into vacation mode and take it easy in one of Southern Illinois's multiple hotels with air conditioning. With a total average guest review rating of 9.0, there's something for everyone, no matter your style and budget. Many visitors to O'Fallon love staying at Drury Inn & Suites St. Louis O'Fallon, IL, a highly rated 3-stars retreat with a swimming pool, blackout curtains and air conditioning. Another guest favorite in this popular city is Hampton Inn O'Fallon. This 2.5-stars escape comes with an electric car charging station and a swimming pool.
How many hotels with air conditioning are there in Southern Illinois?
Southern Illinois has 198 hotels with air conditioning to choose from. Enter your travel dates and destination and organize your dream getaway today.
What are the best cheap hotels with air conditioning in Southern Illinois?
Save money on your Southern Illinois vacation by choosing hotels with air conditioning from just P3,754 per night. Planning to explore the must-see attractions of O'Fallon? Unpack your bags at Hampton Inn O'Fallon, an affordable option with in-room AC, an electric car charging station and a swimming pool. If you're basing yourself in Effingham, Holiday Inn Express And Suites Effingham, an IHG Hotel is a superb choice. It offers the air-conditioned comfort your crew needs in addition to a garden and a swimming pool. Discover Southern Illinois on the cheap by filling your travel itinerary with fun and free attractions. St. Clair Bowl in O'Fallon is a must. If your travels take you to Effingham, you won't have to pull out your wallet when visiting Mid America Motorworks, My Garage Museum. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the top motels with air conditioning in Southern Illinois?
Staying in a motel with air conditioning is a terrific way to have a comfortable vacation at an awesome price. If your Southern Illinois travels include time in Alton, Bel Air Motel is a sought-after choice. It's around 8 kilometers southeast of downtown. Offering a barbecue grill and blackout curtains, it's a very pocket-friendly place to recharge after a busy day seeing the sights. Another option with air conditioning is Super 8 by Wyndham Alton. It features a restaurant and front desk services and is around 3 kilometers northeast of the center of Alton.O'Fallon is bursting with fantastic attractions to keep you entertained. Check out The Edge and St. Clair Bowl when you're ready to start exploring.
Are there any family-friendly hotels with air conditioning in Southern Illinois?
You'll find family-friendly hotels with air conditioning in locations across Southern Illinois, including O'Fallon. Drury Inn & Suites St. Louis O'Fallon, IL is one stay that'll fit your needs in this popular city. It has a 3-stars rating and handy amenities like complimentary breakfast and laundry facilities. Alternatively, put your feet up at Drury Inn & Suites St. Louis Fairview Heights. With complimentary breakfast, laundry facilities and AC, this 3-stars favorite in O'Fallon will make your team feel at home. Once you've unpacked your suitcase and settled in, it's time to explore O'Fallon. Look forward to memorable moments together at family-friendly attractions like The Edge and St. Clair Bowl.
Why book your hotel with air conditioning in Southern Illinois with Expedia?
Expedia has unbeatable rates on hotels with air conditioning in Southern Illinois. If you have a set budget, select how much you're willing to spend and the preferred star rating of your hotel. Then take advantage of our filters to search for air-conditioned digs with amenities like a hot tub or a swimming pool. We'll help you find a suitable stay whatever your bank balance or plans.
How can I find cheap hotels with air conditioning in Southern Illinois?
Expedia can help you narrow down your search for cheap hotels with air conditioning in Southern Illinois. Simply click the "air conditioned" box under the amenities filter options to view places that offer this feature. Next, choose your hotel star rating (lower-rated stays are easier on the wallet!) and your budget per night to find the best places with AC at the most affordable price.
What is there to do in Southern Illinois near my hotel with air conditioning?
Wherever you travel in Southern Illinois, you'll find plenty to keep you entertained here. Planning a stop in O'Fallon? The Edge is a great attraction to include in your itinerary.

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