Photo by Southernmost Illinois Tourism Bureau

Business Hotels in Southern Illinois, Illinois

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Check availability on Southern Illinois Business Hotels

Tonight
Jan 5 - Jan 6
Tomorrow
Jan 6 - Jan 7
This weekend
Jan 9 - Jan 11
Next weekend
Jan 16 - Jan 18

Our top choices for Southern Illinois business-friendly hotels

Exterior
Holiday Inn Express & Suites Effingham by IHG

Holiday Inn Express & Suites Effingham by IHG

Holiday Inn Express & Suites Effingham by IHG
2.5 star property
Effingham
9.4 out of 10, Exceptional, (1001)
"Clean room, excellent staff."
United States
Nancy
The price is P5,592
P6,262 total
includes taxes & fees
Jan 9 - Jan 10
Holiday Inn Express & Suites Effingham by IHG
Exterior
Drury Inn & Suites Marion

Drury Inn & Suites Marion

Drury Inn & Suites Marion
3.0 star property
Marion
9.4 out of 10, Exceptional, (1017)
"Very nice hotel! Friendly staff and great amenities. We will definitely stay again during our travels. "
United States
Renee
The price is P3,825
P4,590 total
includes taxes & fees
Jan 17 - Jan 18
Drury Inn & Suites Marion
Free daily continental breakfast
Best Western Delta Inn

Best Western Delta Inn

Best Western Delta Inn
2.5 star property
Effingham
9.2 out of 10, Wonderful, (1001)
"Great breakfast!"
United States
Michele
The price is P4,953
P5,547 total
includes taxes & fees
Feb 3 - Feb 4
Best Western Delta Inn
Lobby
Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
3.0 star property
Mount Vernon
9.6 out of 10, Exceptional, (1613)
"Clean nice people great place to stay"
United States
John
The price is P5,532
P6,258 total
includes taxes & fees
Jan 25 - Jan 26
Drury Plaza Hotel Mt. Vernon
Terrace/patio
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

Comfort Suites Mount Vernon
2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1013)
"It's great for travelers!"
United States
Kerry
The price is P6,660
P7,510 total
includes taxes & fees
Jan 25 - Jan 26
Comfort Suites Mount Vernon
Desk, soundproofing, iron/ironing board, rollaway beds
Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL
2.5 star property
Effingham
8.8 out of 10, Excellent, (1008)
"Clean room, friendly check-in "
United States
Shelley
The price is P5,253
P5,830 total
includes taxes & fees
Feb 1 - Feb 2
Country Inn & Suites by Radisson, Effingham, IL
Lobby
La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham
3.0 star property
Effingham
9.2 out of 10, Wonderful, (1011)
"The staff were friendly and welcoming.the room was perfect. Enjoyed our stay."
United States
Patricia Mahoney
The price is P5,554
P6,219 total
includes taxes & fees
Jan 8 - Jan 9
La Quinta Inn & Suites by Wyndham Effingham
Lobby
SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake
2.5 star property
Whittington
8.8 out of 10, Excellent, (918)
"Great place to stay."
United States
Stephen
The price is P4,237
P4,703 total
includes taxes & fees
Jan 12 - Jan 13
SureStay Hotel by Best Western Whittington Rend Lake
Exterior
Holiday Inn Effingham by IHG

Holiday Inn Effingham by IHG

Holiday Inn Effingham by IHG
3.5 star property
Effingham
9.0 out of 10, Wonderful, (658)
"Nice place with bar and restaurant on site."
United States
Steve
The price is P6,181
P6,921 total
includes taxes & fees
Jan 12 - Jan 13
Holiday Inn Effingham by IHG
Seasonal outdoor pool, pool umbrellas, sun loungers
Quality Inn & Suites Vandalia near I-70 and Hwy 51

Quality Inn & Suites Vandalia near I-70 and Hwy 51

Quality Inn & Suites Vandalia near I-70 and Hwy 51
2.5 star property
Vandalia
8.4 out of 10, Very Good, (1005)
"Great staff, clean rooms"
United States
Hannah
The price is P3,755
P4,093 total
includes taxes & fees
Jan 11 - Jan 12
Quality Inn & Suites Vandalia near I-70 and Hwy 51
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southern Illinois Hotel Reviews

Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

10/10 Excellent
"Great stay"
David 2-night trip
Posted 1 day ago
Drury Inn & Suites St. Louis O'Fallon, IL

Frequently asked questions

How much do business-friendly hotels in Southern Illinois cost?
You'll pay between P4,093 and P7,510 per night for business-friendly hotels in Southern Illinois. Awesome deals on properties that cater to work-related travelers are a few clicks away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Southern Illinois?
That depends on your destination in Southern Illinois. Many business travelers to O'Fallon like to base themselves at Drury Inn & Suites St. Louis O'Fallon, IL. This 3-stars property comes with a swimming pool and complimentary breakfast. Hampton Inn O'Fallon is another top option if you're attending a conference or working remotely in O'Fallon. A swimming pool and an electric car charging station are among the handy amenities at this 2.5-stars getaway. When work takes you on the road, you can choose from multiple business-friendly hotels in Southern Illinois that have a total average guest review rating of 9.0.
How many business-friendly hotels are there in Southern Illinois?
Pick from 149 business-friendly hotels in Southern Illinois. Wherever your job is taking you, Expedia makes it a breeze to find the ideal space with the amenities you want.
What are the best cheap business-friendly hotels in Southern Illinois?
Keep costs low with Expedia's business-friendly hotels in Southern Illinois that start at P4,093 per night. A cheaper property in O'Fallon is Hampton Inn O'Fallon. Corporate guests rate it highly for its many amenities, including an electric car charging station and a swimming pool. If you're basing yourself in Effingham, choose Holiday Inn Express And Suites Effingham, an IHG Hotel. A swimming pool and a garden are among the conveniences provided for both business and leisure travelers. You'll find loads of free and interesting things to do wherever you go in Southern Illinois. If you have a meeting or conference in O'Fallon, try to find time to visit St. Clair Bowl. You can also go sightseeing for a song in Effingham. Mid America Motorworks, My Garage Museum is one of the best free attractions here. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Are there any family-friendly hotels in Southern Illinois that are also business friendly?
You'll discover some terrific family-friendly hotels that are also business friendly in Southern Illinois. If you're traveling to O'Fallon, look up Drury Inn & Suites St. Louis O'Fallon, IL. It offers handy amenities such as complimentary breakfast and a laundry service and has a 3-stars rating. Another property worth considering is Drury Inn & Suites St. Louis Fairview Heights. This 3-stars stay in O'Fallon is ideal for both leisure and business travelers and offers complimentary breakfast, a laundry service and much more. Once you've gotten work out of the way, get out and discover O'Fallon with the kids. Favorite family-friendly attractions include The Edge and St. Clair Bowl.
Why book your business-friendly hotel in Southern Illinois with Expedia?
At Expedia, we make it our job to help you locate an amazing stay at the right price. From luxurious, corporate-friendly properties to affordable hotels filled with handy amenities, you'll have your next work trip booked in a few easy clicks.
How can I find cheap business-friendly hotels in Southern Illinois?
When you're traveling for work in Southern Illinois, our "business friendly" filter will help you find the ideal hotel. From free WiFi to workspaces and meeting rooms, they have the amenities you need to be productive. Another useful tip? Refine your search by your budget and preferred star rating to view the most affordable options.
What is there to do in Southern Illinois near my business-friendly hotel?
Southern Illinois has so much to see and do, it can be tricky to figure out where to start. If you're spending a few nights in O'Fallon, The Edge is a much-loved attraction here.

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