Business Hotels in Southern Illinois, Illinois

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Illinois Business Hotels

Our top choices for Southern Illinois business-friendly hotels

Lobby

Drury Inn & Suites Marion

Drury Inn & Suites Marion
3.0 star property
Marion
9.4 out of 10, Exceptional, (1,008 reviews)
"Lovely hotel with exceptionally nice staff and clean and great room!"
United States
Eileen
The price is P6,058
P7,269 total
includes taxes & fees
May 10 - May 11
Drury Inn & Suites Marion
Lobby lounge

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
3.0 star property
Mount Vernon
9.6 out of 10, Exceptional, (1,667 reviews)
"Beautiful hotel and loved the kickback and breakfast."
United States
Lori
The price is P6,178
P6,977 total
includes taxes & fees
Apr 26 - Apr 27
Drury Plaza Hotel Mt. Vernon
Front of property - evening/night

Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL
2.5 star property
Effingham
8.8 out of 10, Excellent, (1,011 reviews)
"Clean room, comfy beds, easy and friendly check in. "
United States
Renee
The price is P4,559
P5,060 total
includes taxes & fees
May 3 - May 4
Country Inn & Suites by Radisson, Effingham, IL
Exterior

La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham
3.0 star property
Effingham
9.2 out of 10, Wonderful, (1,003 reviews)
" Very pleased with our stay "
United States
Nancy
The price is P5,813
P6,509 total
includes taxes & fees
May 3 - May 4
La Quinta Inn & Suites by Wyndham Effingham
Exterior

Holiday Inn Express & Suites Vandalia by IHG

Holiday Inn Express & Suites Vandalia by IHG
2.5 star property
Vandalia
8.8 out of 10, Excellent, (810 reviews)
"Easy access good breakfast "
United States
Jeff
The price is P6,274
P6,838 total
includes taxes & fees
Apr 19 - Apr 20
Holiday Inn Express & Suites Vandalia by IHG
Sauna, hot tub, body treatments, hot stone massages

Walker's Bluff Casino Resort

Walker's Bluff Casino Resort
4.5 star property
Carterville
9.4 out of 10, Exceptional, (427 reviews)
"Great place!"
United States
Paula
The price is P7,796
P8,652 total
includes taxes & fees
Apr 12 - Apr 13
Walker's Bluff Casino Resort
Lobby

SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake
2.5 star property
Whittington
8.8 out of 10, Excellent, (948 reviews)
"We were looking for a hotel close to Pheasant Hollow Winery in order to attend one of their special events. We hit the jackpot with SureStay... it is only a couple minutes from the winery and is very clean, quiet and apparently efficiently run. We will definitely use in the future. "
United States
Randall
The price is P5,128
P5,692 total
includes taxes & fees
Apr 26 - Apr 27
SureStay Hotel by Best Western Whittington Rend Lake
Exterior

Holiday Inn Effingham by IHG

Holiday Inn Effingham by IHG
3.5 star property
Effingham
9.0 out of 10, Wonderful, (671 reviews)
"easy arrival, nice room"
United States
Susan
The price is P5,796
P6,490 total
includes taxes & fees
Apr 19 - Apr 20
Holiday Inn Effingham by IHG
Indoor pool

Best Western Delta Inn

Best Western Delta Inn
2.5 star property
Effingham
9.2 out of 10, Wonderful, (1,003 reviews)
"Great staff, clean room, and good breakfast!"
United States
Gayle
The price is P5,406
P6,053 total
includes taxes & fees
May 3 - May 4
Best Western Delta Inn
Lobby

Comfort Suites Mount Vernon

Comfort Suites Mount Vernon
2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1,032 reviews)
"Clean room, friendly staff, great rate, and great amenities. Would definitely stay again"
United States
Lisa
The price is P6,755
P7,616 total
includes taxes & fees
May 3 - May 4
Comfort Suites Mount Vernon
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Southern Illinois Hotel Reviews

Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

10/10 Excellent
"Rooms and all public areas were clean and looked fresh and new. Close to the highway without being right on it."
Michelle 1-night trip
Posted 9 hours ago
Comfort Suites Mount Vernon

Frequently asked questions

How much do business-friendly hotels in Southern Illinois cost?
You'll pay between P5,060 and P8,652 per night for business-friendly hotels in Southern Illinois. Awesome deals on properties that cater to work-related travelers are a few clicks away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Southern Illinois?
That depends on your destination in Southern Illinois. Many business travelers to O'Fallon like to base themselves at Drury Inn & Suites St. Louis O'Fallon, IL. This 3-stars property comes with a swimming pool and complimentary breakfast. Hampton Inn O'Fallon is another top option if you're attending a conference or working remotely in O'Fallon. A swimming pool and an electric car charging station are among the handy amenities at this 2.5-stars getaway. When work takes you on the road, you can choose from multiple business-friendly hotels in Southern Illinois that have a total average guest review rating of 9.1.
How many business-friendly hotels are there in Southern Illinois?
Pick from 149 business-friendly hotels in Southern Illinois. Wherever your job is taking you, Expedia makes it a breeze to find the ideal space with the amenities you want.
What are the best cheap business-friendly hotels in Southern Illinois?
Keep costs low with Expedia's business-friendly hotels in Southern Illinois that start at P5,060 per night. A cheaper property in O'Fallon is Hampton Inn O'Fallon. Corporate guests rate it highly for its many amenities, including an electric car charging station and a swimming pool. If you're basing yourself in Effingham, choose Holiday Inn Express And Suites Effingham, an IHG Hotel. A swimming pool and a garden are among the conveniences provided for both business and leisure travelers. You'll find loads of free and interesting things to do wherever you go in Southern Illinois. If you have a meeting or conference in O'Fallon, try to find time to visit St. Clair Bowl. You can also go sightseeing for a song in Effingham. Mid America Motorworks, My Garage Museum is one of the best free attractions here. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Are there any family-friendly hotels in Southern Illinois that are also business friendly?
You'll discover some terrific family-friendly hotels that are also business friendly in Southern Illinois. If you're traveling to O'Fallon, look up Drury Inn & Suites St. Louis O'Fallon, IL. It offers handy amenities such as complimentary breakfast and a laundry service and has a 3-stars rating. Another property worth considering is Drury Inn & Suites St. Louis Fairview Heights. This 3-stars stay in O'Fallon is ideal for both leisure and business travelers and offers complimentary breakfast, a laundry service and much more. Once you've gotten work out of the way, get out and discover O'Fallon with the kids. Favorite family-friendly attractions include The Edge and St. Clair Bowl.
Why book your business-friendly hotel in Southern Illinois with Expedia?
At Expedia, we make it our job to help you locate an amazing stay at the right price. From luxurious, corporate-friendly properties to affordable hotels filled with handy amenities, you'll have your next work trip booked in a few easy clicks.
How can I find cheap business-friendly hotels in Southern Illinois?
When you're traveling for work in Southern Illinois, our "business friendly" filter will help you find the ideal hotel. From free WiFi to workspaces and meeting rooms, they have the amenities you need to be productive. Another useful tip? Refine your search by your budget and preferred star rating to view the most affordable options.
What is there to do in Southern Illinois near my business-friendly hotel?
Southern Illinois has so much to see and do, it can be tricky to figure out where to start. If you're spending a few nights in O'Fallon, The Edge is a much-loved attraction here.

Explore a world of travel with Expedia