Business Hotels in Southern Illinois, Illinois

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Illinois Business Hotels

Tonight
Feb 25 - Feb 26
Tomorrow
Feb 26 - Feb 27
This weekend
Feb 27 - Mar 1
Next weekend
Mar 6 - Mar 8

Our top choices for Southern Illinois business-friendly hotels

Lobby lounge

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
3.0 star property
Mount Vernon
9.6 out of 10, Exceptional, (1,663 reviews)
"Hotel is very clean, nicely furnished and the beds were so comfy!"
United States
Christina
The price is P6,505
P7,334 total
includes taxes & fees
Mar 6 - Mar 7
Drury Plaza Hotel Mt. Vernon
Exterior

Holiday Inn Express & Suites Effingham by IHG

Holiday Inn Express & Suites Effingham by IHG
2.5 star property
Effingham
9.4 out of 10, Exceptional, (1,000 reviews)
"Room was clean, staff was very pleasant, breakfast was delicious and plentiful and we were able to enjoy all amenities. "
United States
Laura
The price is P5,961
P6,676 total
includes taxes & fees
Feb 28 - Mar 1
Holiday Inn Express & Suites Effingham by IHG
Lobby

Drury Inn & Suites Marion

Drury Inn & Suites Marion
3.0 star property
Marion
9.4 out of 10, Exceptional, (1,006 reviews)
"All of the above, enjoyed the evening meal and breakfast, also staff was very friendly. "
United States
Barbara
The price is P5,699
P6,837 total
includes taxes & fees
Mar 13 - Mar 14
Drury Inn & Suites Marion
Exterior

La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham
3.0 star property
Effingham
9.2 out of 10, Wonderful, (1,007 reviews)
"Staff was amazing and the brekfast was good too!"
United States
Kevin
The price is P5,598
P6,269 total
includes taxes & fees
Mar 1 - Mar 2
La Quinta Inn & Suites by Wyndham Effingham
Meeting facility

Holiday Inn Effingham by IHG

Holiday Inn Effingham by IHG
3.5 star property
Effingham
9.0 out of 10, Wonderful, (663 reviews)
"Nice place with bar and restaurant on site."
United States
Steve
The price is P5,268
P5,899 total
includes taxes & fees
Feb 28 - Mar 1
Holiday Inn Effingham by IHG
Front of property - evening/night

Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL
2.5 star property
Effingham
8.8 out of 10, Excellent, (1,002 reviews)
"Clean, friendly staff and good breakfast. Location is excellent. "
United States
Maria
The price is P5,156
P5,722 total
includes taxes & fees
Mar 22 - Mar 23
Country Inn & Suites by Radisson, Effingham, IL
Free daily continental breakfast

Best Western U. S. Inn

Best Western U. S. Inn
2.5 star property
Nashville
8.6 out of 10, Excellent, (402 reviews)
"Good staff "
United States
Jose Diego
The price is P5,065
P5,520 total
includes taxes & fees
Feb 27 - Feb 28
Best Western U. S. Inn
Lobby

SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake
2.5 star property
Whittington
8.8 out of 10, Excellent, (933 reviews)
"Great place to stay."
United States
Stephen
The price is P4,403
P4,887 total
includes taxes & fees
Mar 3 - Mar 4
SureStay Hotel by Best Western Whittington Rend Lake
Lobby

Comfort Suites Mount Vernon

Comfort Suites Mount Vernon
2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1,002 reviews)
"Very clean and safe stay!"
United States
Dale
The price is P6,226
P7,025 total
includes taxes & fees
Mar 8 - Mar 9
Comfort Suites Mount Vernon
Exterior

Best Western Plus Parkside Inn & Suites

Best Western Plus Parkside Inn & Suites
2.5 star property
Olney
9.8 out of 10, Exceptional, (331 reviews)
"Awesome staff, room and breakfast "
United States
Marjorie
The price is P6,825
P7,574 total
includes taxes & fees
Mar 6 - Mar 7
Best Western Plus Parkside Inn & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Southern Illinois Hotel Reviews

Fairfield Inn & Suites St. Louis Pontoon Beach/Granite City

Fairfield Inn & Suites St. Louis Pontoon Beach/Granite City

10/10 Excellent
"The homeless nice and rooms clean. Nice assortment for breakfast. Definitely will go back. "
Darren 1-night trip
Posted 2 days ago
Fairfield Inn & Suites St. Louis Pontoon Beach/Granite City

Frequently asked questions

How much do business-friendly hotels in Southern Illinois cost?
You'll pay between P4,887 and P7,574 per night for business-friendly hotels in Southern Illinois. Awesome deals on properties that cater to work-related travelers are a few clicks away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Southern Illinois?
That depends on your destination in Southern Illinois. Many business travelers to O'Fallon like to base themselves at Drury Inn & Suites St. Louis O'Fallon, IL. This 3-stars property comes with a swimming pool and complimentary breakfast. Hampton Inn O'Fallon is another top option if you're attending a conference or working remotely in O'Fallon. A swimming pool and an electric car charging station are among the handy amenities at this 2.5-stars getaway. When work takes you on the road, you can choose from multiple business-friendly hotels in Southern Illinois that have a total average guest review rating of 9.2.
How many business-friendly hotels are there in Southern Illinois?
Pick from 149 business-friendly hotels in Southern Illinois. Wherever your job is taking you, Expedia makes it a breeze to find the ideal space with the amenities you want.
What are the best cheap business-friendly hotels in Southern Illinois?
Keep costs low with Expedia's business-friendly hotels in Southern Illinois that start at P4,887 per night. A cheaper property in O'Fallon is Hampton Inn O'Fallon. Corporate guests rate it highly for its many amenities, including an electric car charging station and a swimming pool. If you're basing yourself in Effingham, choose Holiday Inn Express And Suites Effingham, an IHG Hotel. A swimming pool and a garden are among the conveniences provided for both business and leisure travelers. You'll find loads of free and interesting things to do wherever you go in Southern Illinois. If you have a meeting or conference in O'Fallon, try to find time to visit St. Clair Bowl. You can also go sightseeing for a song in Effingham. Mid America Motorworks, My Garage Museum is one of the best free attractions here. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Are there any family-friendly hotels in Southern Illinois that are also business friendly?
You'll discover some terrific family-friendly hotels that are also business friendly in Southern Illinois. If you're traveling to O'Fallon, look up Drury Inn & Suites St. Louis O'Fallon, IL. It offers handy amenities such as complimentary breakfast and a laundry service and has a 3-stars rating. Another property worth considering is Drury Inn & Suites St. Louis Fairview Heights. This 3-stars stay in O'Fallon is ideal for both leisure and business travelers and offers complimentary breakfast, a laundry service and much more. Once you've gotten work out of the way, get out and discover O'Fallon with the kids. Favorite family-friendly attractions include The Edge and St. Clair Bowl.
Why book your business-friendly hotel in Southern Illinois with Expedia?
At Expedia, we make it our job to help you locate an amazing stay at the right price. From luxurious, corporate-friendly properties to affordable hotels filled with handy amenities, you'll have your next work trip booked in a few easy clicks.
How can I find cheap business-friendly hotels in Southern Illinois?
When you're traveling for work in Southern Illinois, our "business friendly" filter will help you find the ideal hotel. From free WiFi to workspaces and meeting rooms, they have the amenities you need to be productive. Another useful tip? Refine your search by your budget and preferred star rating to view the most affordable options.
What is there to do in Southern Illinois near my business-friendly hotel?
Southern Illinois has so much to see and do, it can be tricky to figure out where to start. If you're spending a few nights in O'Fallon, The Edge is a much-loved attraction here.

Explore a world of travel with Expedia