A beach with a pier extending into the ocean, a person standing on the shore, and the sun setting over the water.

South San Diego Vacation Rentals

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Oct 2 - Oct 4
In two months
Nov 13 - Nov 15
In three months
Dec 11 - Dec 13
In four months
Jan 8 - Jan 10

Our top choices for South San Diego vacation rentals

Lobby

1. Little Italy Inn - Limited Service Apart Hotel

Little Italy Inn - Limited Service Apart Hotel
2.5 star property
Downtown San Diego
8.2 out of 10, Very good, (303 reviews)
"Very close to little Italy with tons of good food."
United States
Laura
The price is P6,137
P7,103 total
includes taxes & fees
Sep 28 - Sep 29
Little Italy Inn - Limited Service Apart Hotel
Terrace/patio

2. City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (206 reviews)
"Receptionist was super nice and super helpful. The location was perfect. Everything was super close. Loved the room."
United States
Victor
The price is P7,276
P10,338 total
includes taxes & fees
Sep 30 - Oct 1
City24 Hotel Little Italy Mission Hills
Beach nearby

3. Coronado Beach Resort

Coronado Beach Resort
3.0 star property
Historic Downtown Coronado
9.0 out of 10, Wonderful, (819 reviews)
"The staff was wonderful and they had get togethers in the lobby and activities!"
United States
Phyllis
The price is P13,265
P14,591 total
includes taxes & fees
Sep 27 - Sep 28
Coronado Beach Resort
Lobby sitting area

4. Uptown Inn by Vantaggio - Limited Service Apart-Hotel

Uptown Inn by Vantaggio - Limited Service Apart-Hotel
2.5 star property
Hillcrest
8.4 out of 10, Very good, (466 reviews)
"It's good hotel for small day 1 to 3 nights no more then that due to the size of the room."
Canada
patrick
The price is P6,050
P6,822 total
includes taxes & fees
Oct 12 - Oct 13
Uptown Inn by Vantaggio - Limited Service Apart-Hotel
Exterior

5. Marriott Vacation Club®, San Diego

Marriott Vacation Club®, San Diego
3.5 star property
Downtown San Diego
9.4 out of 10, Exceptional, (1,209 reviews)
"Great for traveling families."
United States
Veronica Dangerfield
The price is P10,608
P12,300 total
includes taxes & fees
Sep 29 - Sep 30
Marriott Vacation Club®, San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top South San Diego Hotel Reviews

The Dana on Mission Bay

The Dana on Mission Bay

10/10 Excellent
"Stayed here for a family getaway and had an amazing time with the kids! The property grounds are absolutely beautiful, but the highlight was the staff. They were incredibly thoughtful, caring, and went out of their way to make sure our family was comfortable. It is the perfect place for a stress-free family vacation. Highly recommend!"
Ani 3-night trip
Posted 1 hour ago
The Dana on Mission Bay

Find out more about South San Diego

Search for holiday rentals in South San Diego on Expedia! You can easily find your home rentals, villas, holiday apartments in South San Diego using one of the methods below:

  • View our selection of featured holiday rentals in South San Diego
  • Use the map to find apartments and other holiday homes in the South San Diego neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in South San Diego while they last

Look no further and take a look at our great range of rental properties in South San Diego!