Hotels near Sioux Empire Medical Museum

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Dec 23 - Dec 24
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Dec 24 - Dec 25
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

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Our top choices for Sioux Empire Medical Museum hotels

Interior detail
Hotel On Phillips

Hotel On Phillips

Hotel On Phillips
2.5 star property
Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum
9.6 out of 10, Exceptional, (1305)
"Great staff and location!"
United States
Gerald
Hotel On Phillips
Terrace/patio
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center
3.0 star property
University Heights, 0.2 km from Sioux Empire Medical Museum
9.4 out of 10, Exceptional, (585)
"This is a great hotel - centrally located and very clean and quiet. Will definitely be staying there again. "
United States
Tracey
The price is P5,923
P6,615 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center
Free daily continental breakfast
Clubhouse Hotel Suites Sioux Falls

Clubhouse Hotel Suites Sioux Falls

Clubhouse Hotel Suites Sioux Falls
3.0 star property
Mall District, 2.8 km from Sioux Empire Medical Museum
9.4 out of 10, Exceptional, (1005)
"Absolutely beautiful places to stay with family excellent service staff great food service great hospitality great "
United States
Rosario
Clubhouse Hotel Suites Sioux Falls
Meeting facility
Canopy By Hilton Sioux Falls Downtown

Canopy By Hilton Sioux Falls Downtown

Canopy By Hilton Sioux Falls Downtown
4.0 star property
Downtown Sioux Falls, 2.5 km from Sioux Empire Medical Museum
9.4 out of 10, Exceptional, (159)
"Room was very clean, great overall stay."
United States
Destiny
The price is P7,656
P8,751 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Canopy By Hilton Sioux Falls Downtown
Front of property - evening/night
Hampton Inn Sioux Falls

Hampton Inn Sioux Falls

Hampton Inn Sioux Falls
2.5 star property
Mall District, 3.1 km from Sioux Empire Medical Museum
9.2 out of 10, Wonderful, (1007)
"It was a very nice stay. "
United States
Lenore
The price is P5,730
P6,403 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Hampton Inn Sioux Falls
Living area
Hilton Garden Inn Sioux Falls Downtown

Hilton Garden Inn Sioux Falls Downtown

Hilton Garden Inn Sioux Falls Downtown
3.0 star property
Downtown Sioux Falls, 2.1 km from Sioux Empire Medical Museum
8.8 out of 10, Excellent, (887)
"Friendly front desk staff, clean room, great location, safe "
United States
Hannah
The price is P6,109
P7,054 total
includes taxes & fees
Dec 29 - Dec 30
Hilton Garden Inn Sioux Falls Downtown
Porch
Historic Victorian Inn

Historic Victorian Inn

Historic Victorian Inn
3.0 star property
Cathedral, 1.5 km from Sioux Empire Medical Museum
8.8 out of 10, Excellent, (56)
"It was a great place to stay and super interesting."
United States
Kathy
The price is P6,890
P8,522 total
includes taxes & fees
Dec 26 - Dec 27
Historic Victorian Inn
Exterior
Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG
2.5 star property
Mall District, 3.1 km from Sioux Empire Medical Museum
8.8 out of 10, Excellent, (1001)
"The breakfast was amazing and plenty of options with cold food and hot. The staff were great too and so was our room. "
United States
JACKIE
The price is P7,516
P8,363 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG
Exterior
Holiday Inn Sioux Falls-City Centre by IHG

Holiday Inn Sioux Falls-City Centre by IHG

Holiday Inn Sioux Falls-City Centre by IHG
3.0 star property
Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum
8.6 out of 10, Excellent, (1001)
"Always a great stay. "
United States
Shawn
The price is P6,048
P6,753 total
includes taxes & fees
Dec 25 - Dec 26
Holiday Inn Sioux Falls-City Centre by IHG
Lobby
Sheraton Sioux Falls Hotel & Convention Center

Sheraton Sioux Falls Hotel & Convention Center

Sheraton Sioux Falls Hotel & Convention Center
4.0 star property
Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum
8.6 out of 10, Excellent, (1002)
"Great hotel. Staff was excellent "
United States
Kristina
The price is P5,690
P6,360 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Sheraton Sioux Falls Hotel & Convention Center
Exterior
Country Inn & Suites by Radisson, Sioux Falls

Country Inn & Suites by Radisson, Sioux Falls

Country Inn & Suites by Radisson, Sioux Falls
3.0 star property
Downtown Sioux Falls, 2 km from Sioux Empire Medical Museum
8.4 out of 10, Very Good, (1160)
"It was a great place to stay!"
United States
Trinity
The price is P4,913
P5,507 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Country Inn & Suites by Radisson, Sioux Falls
Free daily continental breakfast
The Center Inn

The Center Inn

The Center Inn
2.5 star property
All Saints, 2.4 km from Sioux Empire Medical Museum
8.4 out of 10, Very Good, (703)
"Room and staff were great. "
United States
Annette
The Center Inn
Desk, free WiFi, wheelchair access
Valley Inn

Valley Inn

Valley Inn
2.5 star property
University Heights, 0.2 km from Sioux Empire Medical Museum
7.8 out of 10, Good, (1000)
"Room was clean, staff was friendly, very convenient location "
United States
Theresa
Valley Inn
3 indoor pools, open 9:00 AM to 10:00 PM, sun loungers
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
3.0 star property
Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum
7.8 out of 10, Good, (1459)
"staff was friendly "
United States
Rob
The price is P3,772
P4,256 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
Pool
Ramada by Wyndham Sioux Falls Arpt & Suites

Ramada by Wyndham Sioux Falls Arpt & Suites

Ramada by Wyndham Sioux Falls Arpt & Suites
2.0 star property
Northwest Sioux Falls, 3 km from Sioux Empire Medical Museum
7.0 out of 10, Good, (52)
"Very friendly at check in. Great service at bar."
United States
Chris
Ramada by Wyndham Sioux Falls Arpt & Suites
Lobby
Ramada by Wyndham Sioux Falls

Ramada by Wyndham Sioux Falls

Ramada by Wyndham Sioux Falls
2.0 star property
2.6 km from Sioux Empire Medical Museum
5.6 out of 10, (1001)
"Good room for the price."
United States
Michael
The price is P2,995
P3,403 total
includes taxes & fees
Dec 29 - Dec 30
Ramada by Wyndham Sioux Falls
Dining room
Historic Twin Tudors Inn

Historic Twin Tudors Inn

Historic Twin Tudors Inn
3.0 star property
1.4 km from Sioux Empire Medical Museum
8.8 out of 10, Excellent, (3)
"Lovely place! Wish we could have stayed longer. Steve was attentive and helpful. "
United States
Anonymous traveler
The price is P15,802
P17,919 total
includes taxes & fees
Dec 24 - Dec 25
Historic Twin Tudors Inn
Terrace/patio
Hyatt Place Sioux Falls South

Hyatt Place Sioux Falls South

Hyatt Place Sioux Falls South
3.0 star property
Mall District, 3.7 km from Sioux Empire Medical Museum
9.4 out of 10, Exceptional, (1002)
"Great stay!"
United States
Nick
The price is P6,870
P7,654 total
includes taxes & fees
Dec 29 - Dec 30
Hyatt Place Sioux Falls South
Free cribs/infant beds, free WiFi, bed sheets
Staybridge Suites Sioux Falls Southwest by IHG

Staybridge Suites Sioux Falls Southwest by IHG

Staybridge Suites Sioux Falls Southwest by IHG
3.0 star property
South Sioux Falls, 5.2 km from Sioux Empire Medical Museum
9.6 out of 10, Exceptional, (458)
"Staff was great, all very friendly. Room was very clean, and we had a great nights sleep. "
United States
Eric
The price is P5,285
P5,915 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Staybridge Suites Sioux Falls Southwest by IHG
Desk, laptop workspace, soundproofing, iron/ironing board
Comfort Inn & Suites at Sanford Sports Complex

Comfort Inn & Suites at Sanford Sports Complex

Comfort Inn & Suites at Sanford Sports Complex
2.5 star property
Northwest Sioux Falls, 6 km from Sioux Empire Medical Museum
9.6 out of 10, Exceptional, (902)
"Perfect stay. This is what clean, quiet and convenient looks like at an affordable price. "
United States
Tiffany
The price is P5,549
P6,204 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Comfort Inn & Suites at Sanford Sports Complex
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Sioux Empire Medical Museum Hotel Reviews

Canopy By Hilton Sioux Falls Downtown

Canopy By Hilton Sioux Falls Downtown

10/10 Excellent
"A very nice room in a new modern area"
Robert 1-night trip
Posted 4 days ago
Canopy By Hilton Sioux Falls Downtown

Hotels near other Sioux Empire Medical Museum attractions

Great Plains Zoo

4.3/5 (74 reviews)
Why not visit the native and exotic animals who live at Great Plains Zoo during your travels in Sioux Falls? Attend a sporting event or discover the area's beautiful waterfalls.
See properties

University of Sioux Falls

4.1/5 (170 reviews)
Take a campus tour or just explore the area of University of Sioux Falls, during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.
See properties

Frequently asked questions

What's the area like around Sioux Empire Medical Museum?
Sioux Empire Medical Museum is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, check out the 106 hotels and other accommodations you'll find within a mile.
What's the best place to stay close to Sioux Empire Medical Museum?
Adjacent to Sioux Empire Medical Museum, Home2 Suites By Hilton Sioux Falls/Sanford Medical Center is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. Another good choice is Valley Inn, located just 0.1 mi (0.2 km) away.
How many hotels will I be able to find close to Sioux Empire Medical Museum?
Expedia has 106 hotels and other accommodations within a mile from Sioux Empire Medical Museum.
If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund?
Yes, most hotel room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to review the best options available near Sioux Empire Medical Museum.
What can I see and do near Sioux Empire Medical Museum?
Washington Pavilion of Arts and Science, Center for Western Studies, and Old Courthouse Museum feature a variety of fascinating exhibits to see while you're in town. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. You can wander around Falls Park, Sherman Park, or Fawick Park if you want a dose of fresh air.