Top 10 Hotels Near Sioux Empire Medical Museum in Sioux Falls for 2026

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Our top choices for Sioux Empire Medical Museum hotels

A spacious bar area with a large TV screen, a fireplace, and a wine rack.

A spacious living room with a fireplace, large windows, and modern furniture.

A hotel room with a large bed, wooden wardrobe, a TV, and a kitchenette area.

A spacious lobby with modern seating, large windows, and a city view.

1. Highpoint Hotel

University Heights, 0.2 km from Sioux Empire Medical Museum

Diane

P8,568

P9,524 total

includes taxes & fees

Oct 25 - Oct 26

A large, two-story building with a stone facade and multiple windows, illuminated by warm lighting.

A stone pillar with a fire pit in the center, surrounded by blue chairs.

A spacious lobby with a central seating area, a staircase, and a fireplace.

An indoor swimming pool with a water slide, a large umbrella structure, and a frog-shaped water feature.

2. Clubhouse Hotel Suites Sioux Falls

Mall District, 2.8 km from Sioux Empire Medical Museum

Claudine

P8,368

P10,039 total

includes taxes & fees

Oct 8 - Oct 9

A lobby with a large safe, a checkered floor, and a sofa with cushions.

A modern hotel room with a large bed, a decorative wall, a nightstand, a chair, and a large window with a city view.

A lobby with a grand chandelier, blue curtains, and a round glass table with a vase of flowers.

A bar area with high stools and tables, a bar counter with bottles, and a seating area with cushioned chairs.

3. Hotel On Phillips

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Frank

P9,360

P10,394 total

includes taxes & fees

Oct 4 - Oct 5

A patio with wicker chairs and a round table with a fire pit.

An indoor swimming pool with two lanes, safety railings, and lounge chairs.

A modern hotel room with a dining area, a sofa, a desk, and a chair.

A breakfast area with a long table, orange chairs, and various breakfast items displayed on shelves.

4. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

University Heights, 0.2 km from Sioux Empire Medical Museum

Ross

P9,707

P10,773 total

includes taxes & fees

Oct 4 - Oct 5

A Hampton Inn hotel with a modern design, featuring a prominent red sign, a covered entrance, and stone pillars.

A hotel lobby with a bar area, seating, and a television.

A hotel room with a desk, two beds, a TV, and a window with a striped blind.

A swimming pool with clear water, surrounded by a tiled deck and seating areas.

5. Hampton Inn Sioux Falls

Mall District, 3.1 km from Sioux Empire Medical Museum

Derrick

P6,737

P7,516 total

includes taxes & fees

Oct 18 - Oct 19

A modern lobby with a glass fireplace, seating areas, and indoor plants.

A modern building with a sign reading "THE STEEL DISTRICT" and a covered walkway.

A modern kitchen with a central island, bar stools, pendant lights, and a view through large glass doors.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

6. Canopy By Hilton Sioux Falls Downtown

Downtown Sioux Falls, 2.5 km from Sioux Empire Medical Museum

Marius

P12,788

P14,529 total

includes taxes & fees

Oct 4 - Oct 5

A covered outdoor area with a wooden railing, chairs, and tables.

A traditional room with wooden paneling, a sofa, armchairs, a patterned rug, and stained glass windows.

A two-story house with a front porch, a central entrance, and a small garden area.

A kitchen with white cabinets, granite countertops, stainless steel appliances, and a chandelier.

7. Historic Victorian Inn

Cathedral, 1.5 km from Sioux Empire Medical Museum

Jackie

P6,731

P8,411 total

includes taxes & fees

Oct 6 - Oct 7

A long communal dining table with chairs, a bar area with shelves of bottles, and a brick wall with a mirror.

A multi-story hotel with a modern design, featuring balconies on each floor and a visible restaurant named "CRAVE" at the ground level.

A spacious hallway with a patterned carpet, large windows, and seating areas.

A multi-story hotel with a modern design, featuring a central courtyard and a river in front.

8. Hilton Garden Inn Sioux Falls Downtown

Downtown Sioux Falls, 2.1 km from Sioux Empire Medical Museum

Todd

P7,949

P9,221 total

includes taxes & fees

Oct 25 - Oct 26

A buffet with labeled containers of omelets and other dishes.

A reception area with a glass door entrance, a reception desk, and a computer station.

A snack and beverage display with various brands and products.

A Holiday Inn Express & Suites building with a brick facade, illuminated signage, and a covered entrance area.

9. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Mall District, 3.1 km from Sioux Empire Medical Museum

John

P6,585

P7,349 total

includes taxes & fees

Sep 27 - Sep 28

A spacious lobby with multiple seating areas, a bar, and a staircase leading to an upper level.

A modern hotel room with a large window, a round coffee table, a sofa, a chair, and a small table with a lamp.

A hotel room with a bed, a sofa, a chair, a desk, and a large window with a city view.

A large conference room with a central stage, round tables with white chairs, and a patterned carpet.

10. Holiday Inn Sioux Falls-City Centre by IHG

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Rachael

P6,889

P8,622 total

includes taxes & fees

Oct 25 - Oct 26

A multi-level hotel lobby with a central seating area, multiple floors, and a variety of amenities including a bar and dining space.

A multi-level hotel lobby with a central atrium, multiple floors, and a variety of seating areas.

A multi-level hotel lobby with a central courtyard, featuring a patterned floor, multiple levels of balconies, and a rock formation.

An indoor swimming pool with clear windows, chairs, and a tiled floor.

11. Sheraton Sioux Falls Hotel & Convention Center

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

Joan

P6,601

P7,367 total

includes taxes & fees

Oct 4 - Oct 5

A multi-story hotel with a flat roof, a landscaped area with a water feature, and a bridge connecting to another building.

A restaurant with a long wooden table, multiple chairs, a bar area, and a stone wall.

A hotel room with a large bed, a desk with a computer, a chair, a lamp, and three framed pictures on the wall.

A hotel room with a wooden table, a laptop, a telephone, a glass of orange juice, a lamp, and a chair.

12. Country Inn & Suites by Radisson, Sioux Falls

Downtown Sioux Falls, 2 km from Sioux Empire Medical Museum

Hayley

P5,970

P6,675 total

includes taxes & fees

Oct 18 - Oct 19

A hotel room with two beds, a desk with a computer, a television, and a couch.

A black leather chair, a floor lamp, and a window with a view of parked cars.

A restaurant interior with wooden tables and chairs, a 'Welcome' sign, decorative wall art, a TV, and a window view.

A hotel reception area with a Christmas tree, a clock, and a sign indicating a non-smoking policy.

13. The Center Inn

All Saints, 2.4 km from Sioux Empire Medical Museum

Marissa

P5,971

P6,675 total

includes taxes & fees

Oct 24 - Oct 25

An indoor pool area with a slide, seating, and tropical decor.

A lobby with a stone fire feature, seating area, and a reception desk.

A restaurant with booths and tables, a TV screen, and a view of the outdoors.

A modern restaurant with a central bar, red cushioned chairs, and a 'TEAM ROOM' sign.

14. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

Sami

P3,886

P4,388 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with a bed, two bedside lamps, a nightstand, a mirror, and a small desk with a telephone.

A small cafe with a 'Good Morning' sign, a coffee machine, a microwave, and a refrigerator.

A small, cozy room with a sofa, two armchairs, a coffee table, and a desk with a lamp. There are two framed pictures on the wall.

15. Valley Inn

University Heights, 0.2 km from Sioux Empire Medical Museum

Raymond

P5,120

P5,742 total

includes taxes & fees

Oct 25 - Oct 26

A living room with a fireplace, a television, a chandelier, a sofa, and a coffee table.

A cozy living room with a sectional sofa, a wooden coffee table, and a chandelier.

A dining room with a wooden table, six chairs, and a chandelier.

A wooden door with a glass panel, leading to a brick-paved entrance.

16. Historic Twin Tudors Inn

1.4 km from Sioux Empire Medical Museum

Anonymous traveler

P15,918

P18,085 total

includes taxes & fees

Sep 30 - Oct 1

17. Sioux Falls Inn

Northwest Sioux Falls, 3.1 km from Sioux Empire Medical Museum

Stephanie

P3,432

P3,890 total

includes taxes & fees

Oct 6 - Oct 7

A multi-story hotel with a modern design, featuring a central entrance and multiple balconies.

Two vending machines in a hallway with a sign that reads "VENDORS".

A laundry room with multiple white washers and dryers, wooden flooring, and a door on the left.

A hotel room with a bed, a window with blinds, a heater, a nightstand, and a painting on the wall.

18. WoodSpring Suites Sioux Falls

2.8 km from Sioux Empire Medical Museum

Catherine

P4,948

P5,553 total

includes taxes & fees

Sep 27 - Sep 28

A reception area with a counter, a food mart sign, and a security camera.

A breakfast bar with seating, a microwave, toaster, and a coffee maker.

A hotel room with two beds, a desk, a chair, and a TV.

A swimming pool with a tiled floor, a poolside table, and chairs.

19. Ramada by Wyndham Sioux Falls

2.6 km from Sioux Empire Medical Museum

Michael

P3,620

P4,096 total

includes taxes & fees

Oct 25 - Oct 26

A modern hotel room with a kitchenette, a bed, a desk, and a chair.

A modern hotel room with a kitchenette, a bed, a sofa, a dining area, and a view of the outdoors.

A modern living room with a flat-screen TV, a sofa, a coffee table, and a dining area with a table and chairs.

A compact hotel room with a kitchenette, a bed, a TV, and a seating area.

20. Staybridge Suites Sioux Falls Southwest by IHG

South Sioux Falls, 5.2 km from Sioux Empire Medical Museum

P7,892

P8,782 total

includes taxes & fees

Oct 18 - Oct 19

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Compare popular hotels close to Sioux Empire Medical Museum

Property	Property class	Guest rating
Highpoint Hotel	9.8 Exceptional 330 reviews	View
Clubhouse Hotel Suites Sioux Falls	9.6 Exceptional 1,217 reviews	View
Hotel On Phillips	9.6 Exceptional 1,589 reviews	View
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center	9.4 Exceptional 673 reviews	View
Hampton Inn Sioux Falls	9.4 Exceptional 1,004 reviews	View

Top Sioux Empire Medical Museum Hotel Reviews

Country Inn & Suites by Radisson, Sioux Falls

10/10 Excellent

"The room was clean and the bed was comfortable. Breakfast was very good with a nice selection. There were grapes as one of the fruits offered! We haven’t had that offered before so it was a very nice choice. Sharon who works the kitchen was super helpful and very kind."

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

8/10 Good

"No breakfast, hair dryer didn't work in either room. Toilet leaked all night. Price was not good for someone who isn't using the water park"

Valley Inn

8/10 Good

"The cost is very reasonable; conveniently located"

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

8.0/10 (242 reviews)

Take a campus tour or just explore the area of University of Sioux Falls, during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

See properties

Augustana College

8.2/10 (310 reviews)

Take a campus tour or just explore the area of Augustana College, during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Center for Western Studies

You can spend time browsing the exhibits at Center for Western Studies in Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Delbridge Museum of Natural History

6.0/10 (1 review)

You can spend time exploring the galleries in Delbridge Museum of Natural History during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Washington Pavilion

Washington Pavilion is just one of the places to see in Sioux Falls, so why not enjoy the other things to explore during your travels?

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Washington Pavilion of Arts and Science

9.0/10 (132 reviews)

You can enjoy a show at Washington Pavilion of Arts and Science on your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Pettigrew Home and Museum

You can spend time browsing the exhibits at Pettigrew Home and Museum during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Club David

After visiting Club David, make a plan to see the other sights and activities in Sioux Falls.

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Frequently asked questions

What's the area like around Sioux Empire Medical Museum?

Sioux Empire Medical Museum is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, check out the 136 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Sioux Empire Medical Museum?

Adjacent to Sioux Empire Medical Museum, Highpoint Hotel is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and free parking. Other good choices close by include Valley Inn and Home2 Suites By Hilton Sioux Falls/Sanford Medical Center.

How many hotels will I be able to find close to Sioux Empire Medical Museum?

Expedia has 136 hotels and other accommodations within a mile from Sioux Empire Medical Museum.

If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund?

Yes, most hotel room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to review the best options available near Sioux Empire Medical Museum.

What can I see and do near Sioux Empire Medical Museum?

Washington Pavilion of Arts and Science, Old Courthouse Museum, and Center for Western Studies feature a variety of fascinating exhibits to see while you're in town. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. You can enjoy live performances at Edith Mortenson Theatre Center and Orpheum Theatre Center.

Hotels near Sioux Empire Medical Museum

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Treat yourself

Be picky

Check prices for these dates

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Our top choices for Sioux Empire Medical Museum hotels

1. Highpoint Hotel

2. Clubhouse Hotel Suites Sioux Falls

3. Hotel On Phillips

4. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

5. Hampton Inn Sioux Falls

6. Canopy By Hilton Sioux Falls Downtown

7. Historic Victorian Inn

8. Hilton Garden Inn Sioux Falls Downtown

9. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

10. Holiday Inn Sioux Falls-City Centre by IHG

11. Sheraton Sioux Falls Hotel & Convention Center

12. Country Inn & Suites by Radisson, Sioux Falls

13. The Center Inn

14. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

15. Valley Inn

16. Historic Twin Tudors Inn

17. Sioux Falls Inn

18. WoodSpring Suites Sioux Falls

19. Ramada by Wyndham Sioux Falls

20. Staybridge Suites Sioux Falls Southwest by IHG

Compare popular hotels close to Sioux Empire Medical Museum

Top Sioux Empire Medical Museum Hotel Reviews

Country Inn & Suites by Radisson, Sioux Falls

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Valley Inn

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

Augustana College

Center for Western Studies

Delbridge Museum of Natural History

Washington Pavilion

Washington Pavilion of Arts and Science

Pettigrew Home and Museum

Club David

Frequently asked questions