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Business Hotels in São Tomé Island, São Tomé and Príncipe

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Check availability on São Tomé Island Business Hotels

Tonight
Dec 25 - Dec 26
Tomorrow
Dec 26 - Dec 27
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

Our top choices for São Tomé Island business-friendly hotels

View from property
Omali São Tomé – Principe Collection

Omali São Tomé – Principe Collection

Omali São Tomé – Principe Collection
4.0 star property
São Tomé
9.4 out of 10, Exceptional, (62)
"It’s a great resort, with friendly staff who "
United Kingdom
Kim
The price is P12,657
P14,847 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Omali São Tomé – Principe Collection
Lobby sitting area
SH Boutique Hotel

SH Boutique Hotel

SH Boutique Hotel
3.5 star property
São Tomé
8.6 out of 10, Excellent, (10)
"Staff were very accommodating "
United States
Simon Peter
SH Boutique Hotel
Outdoor pool, pool umbrellas, sun loungers
Hotel Praia

Hotel Praia

Hotel Praia
3.5 star property
São Tomé
7.6 out of 10, Good, (17)
"Solid, basic hotel. "
United States
Jonathan
The price is P10,045
P11,551 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Hotel Praia
Coffee shop
Hotel Central

Hotel Central

Hotel Central
3.5 star property
São Tomé
8.2 out of 10, Very Good, (24)
"Great value. Great location. Ok breakfast. Overall good value for money"
Norway
Elisabeth
Hotel Central
Poolside bar
Praia Accommodation

Praia Accommodation

Praia Accommodation
3.0 star property
São Tomé
7.2 out of 10, Good, (17)
"Great place to stay "
United States
Daniel
The price is P7,517
P8,644 total
includes taxes & fees
Dec 26 - Dec 27
Praia Accommodation
Desk, blackout drapes, soundproofing, iron/ironing board
Guest House Quinta Natural

Guest House Quinta Natural

Guest House Quinta Natural
3.0 star property
Trindade
10.0 out of 10, Exceptional, (1)
Guest House Quinta Natural
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top São Tomé Island Hotel Reviews

Frequently asked questions

Why book your business-friendly hotel in São Tomé Island with Expedia?
We're here to help you find a great business-friendly hotel when work takes you away from home. From free parking and WiFi to gyms and on-site restaurants, our stays come with the conveniences you'll need to get the job done.
How can I find cheap business-friendly hotels in São Tomé Island?
Expedia can help you easily locate cheap business-friendly hotels in São Tomé Island. Simply go to our "traveler experience" filter and click on "business friendly." This will show you stays with amenities designed to help you work comfortably, like included breakfast and free WiFi. You can also choose your budget and preferred star rating to keep costs under control.
What is there to do in São Tomé Island near my business-friendly hotel?
São Tomé Island has enough sights and experiences to keep you entertained for weeks, starting with Amelia Lagoon. São Nicolau Waterfall, Pico São Tomé and Bom Sucesso Botanical Garden are other impressive attractions. If your business trip keeps you hanging around town a little longer, Paroquia da Santissima Trindade and Batepa Church are great additions to your itinerary.