Use Expedia to arrange your flight to Isla Baltra (GPS-Seymour) airport, and then choose from a variety of places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you want to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Santiago Island offers. Santiago Island has some interesting things to see and do including Galapagos National Park and Mosquera Island, so you might want to take in the local sights during your visit.