Santa Maria Trips (flight + hotel)

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Where to stay in Santa Maria

Find the best Santa Maria areas and neighborhoods for the activities you enjoy most. Learn more about Santa Maria
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Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

Find hotels in Ecuador

Top hotels in Santa Maria

Oro Verde Guayaquil

Oro Verde Guayaquil

5 out of 5
9 De Octubre Y Garcia Moreno, Guayaquil, Guayas
Fully refundableReserve now, pay when you stay
The price is P5,433 per night from Jul 27 to Jul 28
P5,433
P6,120 total
Jul 27 - Jul 28
9.4/10 Exceptional! (1,007 reviews)
"Was greeted at the airport by hotels transport—with name and friendly driver, a surprise and needed at 10:30 pm! Check in was quick, and upgraded to a very nice suite."

Reviewed on Jul 16, 2025

Oro Verde Guayaquil
Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana

4.5 out of 5
Calle Numa Pompilio Llona S N, Ciudad del Rio - Puerto Santa Ana, Guayaquil, Guayas
Fully refundableReserve now, pay when you stay
The price is P6,331 per night from Aug 3 to Aug 4
P6,331
P7,107 total
Aug 3 - Aug 4
9.2/10 Wonderful! (1,003 reviews)
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Reviewed on Jul 18, 2025

Wyndham Guayaquil Puerto Santa Ana
Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG

3.5 out of 5
Av. de Las Américas,junto al Aeropuerto, Intl. Jose Joaquin de Olmedo, Guayaquil, Guayas
Fully refundable
The price is P5,033 per night from Aug 10 to Aug 11
P5,033
P5,679 total
Aug 10 - Aug 11
9.2/10 Wonderful! (1,003 reviews)
Cerca al aeropuerto, restaurantes y malls.
"hotel al lado del aeropuerto, adecuado para viaje de negocios, la almohada es dura para mi gusto y necesidad, lo demás está bien. Restaurante bueno y con amplia oferta"

Reviewed on Jul 20, 2025

Holiday Inn Guayaquil Airport by IHG
See all 385 properties in Santa Maria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Maria vacation package cost?
Get set to book, because a getaway to Santa Maria starts from a tempting . When you combine your hotels, flights and car rentals into a travel package, you'll enjoy the lowest prices.
How do I get a cheap travel package to Santa Maria?
Bundle your hotels and flights with Expedia to save big on your next trip. With more than 550 air carriers and 1,000,000 hotels worldwide, your Santa Maria vacation package can be customized exactly to suit your travel style. With all that extra cash, why not add a few fun activities and tours? It's an easy way to unlock even more savings. Your dream vacation in Santa Maria is closer than you thought!
Where should I stay in Santa Maria?
Make sightseeing easy by staying someplace right around the corner from Santa Maria's biggest attractions. Malecon 2000 and Banco Pichincha Monumental Stadium are two visitor favorites.
How far in advance should I book my Santa Maria vacation?
Your safest bet is to book early. Airlines usually release flight tickets nearly 12 months prior to departure, and this is a great opportunity to score some rock-bottom prices. Just been told you should take your vacation time next month? No sweat. Expedia are never short on fantastic bargains to help you have the getaway of your dreams, at an affordable price.
What does an Expedia Santa Maria travel package include?
Select from any combination of flights, hotels and rental cars. Once you've made your booking, you can add activities and experiences. Want to pick your airfare class? That's easy to do too. The choice is all yours when it comes to arranging your dream Santa Maria escape.
What should I know before booking a Santa Maria travel package?
Get set to save with an Expedia travel package. Combine your flights, rental cars and hotels and enjoy exciting discounts. Hotels aren't your only choice, however. Book with us and choose from beach villas, creek-side mountain cabins and just about everything in between!
Can I choose my airline with a Santa Maria Expedia vacation package?
Expedia offers access to more than 550 airline partners globally, so you certainly can. Just pick your preferred air carrier and put together your ideal Santa Maria escape.
If I'm not able to travel, can I cancel my Santa Maria vacation package?
Yes, you can cancel your Santa Maria booking if your travel plans have been upended. Whether you'll incur a fee or not depends on your airline, hotel or car rental company. It may be possible to cancel or change your booking for free if you booked in the last 24 hours. Head to our Customer Service Portal to learn more.

Popular places to visit

Santa Ana Hill

Santa Ana Hill

Explore the great outdoors at Santa Ana Hill, a lovely green space in Guayaquil. While you're in the area, find time to visit its shops.

Santa Ana Hill

Guayaquil Historic Park

Guayaquil Historic Park is just one of the places to see in Samborondon, so why not enjoy the other things to explore during your travels? While you're in the area, find time to visit its shops.

Guayaquil Historic Park

Civic Center

Explore the great outdoors at Civic Center, a lovely green space in Guayaquil. While you're in the area, find time to visit its shops.

Civic Center

Things to do

Cocoa Farm

Small Group Guayaquil and Cocoa Farm Full-Day Tour

P10,148
per adult
Small Group Guayaquil and Cocoa Farm Full-Day Tour
Full Day Manuel's Waterfalls from Guayaquil

Full Day Manuel's Waterfalls from Guayaquil

P25,652
per adult
Full Day Manuel's Waterfalls from Guayaquil
Guayaquil: Cloud Forest, Hiking & Canyoning Full Day Tour

Guayaquil: Cloud Forest, Hiking & Canyoning Full Day Tour

P17,421
per adult
Guayaquil: Cloud Forest, Hiking & Canyoning Full Day Tour
See all activities in Guayaquil
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.