Santa Cruz Trips (flight + hotel)

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Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
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Centro Político Administrativo

Visitors to Centro Político Administrativo like its parks and riverfront, and Massairo Okamura Park is a sight worth a stop.

Find hotels in Centro Político Administrativo

Top hotels in Santa Cruz

Amazon Aeroporto Hotel

Amazon Aeroporto Hotel

3 out of 5
Avenida Governador Joao Ponce de Arruda, 50, Varzea Grande, Mato Grosso
Fully refundableReserve now, pay when you stay
The price is P5,263 per night from Aug 1 to Aug 2
P5,263
P5,526 total
Aug 1 - Aug 2
includes taxes & fees
9.4/10 Exceptional! (555 reviews)
"Walking distance from the airport but hotel also provides shuttle. Beautifully decorated lobby. All places in the hotel were spotless. Staff was professional and friendly."

Reviewed on Jul 11, 2025

Amazon Aeroporto Hotel
Delmond Hotel

Delmond Hotel

4 out of 5
Av. Andre Antonio Maggi, 1980, Alvorada, Cuiabá, MT
Fully refundableReserve now, pay when you stay
The price is P3,425 per night from Aug 23 to Aug 24
P3,425
P3,881 total
Aug 23 - Aug 24
includes taxes & fees
9/10 Wonderful! (693 reviews)
"Great place for business."

Reviewed on May 31, 2025

Delmond Hotel
Mato Grosso Palace Hotel

Mato Grosso Palace Hotel

3 out of 5
Rua Joaquim Murtinho, 170, Cuiabá, MT
Fully refundableReserve now, pay when you stay
The price is P3,286 per night from Aug 1 to Aug 2
P3,286
P3,384 total
Aug 1 - Aug 2
includes taxes & fees
8.6/10 Excellent! (506 reviews)
"Helpful stuff and good breakfast"

Reviewed on Jul 2, 2025

Mato Grosso Palace Hotel
See all 117 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Cruz vacation package cost?
From just , you can custom build your Santa Cruz vacation package. Simply combine hotels, flights and car rentals and be rewarded with discounts.
How do I get a cheap travel package to Santa Cruz?
It's easy. Just bundle. Flights, hotels and rental cars — combine whatever you need into a Santa Cruz vacation package to save loads of cash. Score even more discounts when you include extras such as day tours to your booking. But that's not the only impressive part. You have the freedom to customize your trip your own way. We offer over 550 air carriers and 1,000,000 hotel options in all corners of the globe, so that everyone has an opportunity to travel and fulfill those vacation fantasies.
Where should I stay in Santa Cruz?
Tick Arena Pantanal off your must-see list and then stay moments from it. Soak up the exciting vibe around this major attraction and visit whenever you like!
How far in advance should I book my Santa Cruz vacation?
Browse Expedia to compare international flights as soon as possible. In many cases, you can purchase a ticket up to a year before departure. If it's too early for your preferred carrier, or you're booking late, don't worry. Cheap tickets to Santa Cruz sometimes appear within weeks of departure.
What does an Expedia Santa Cruz travel package include?
From hotels and airfares to car rentals, Expedia can help you create a Santa Cruz package that's ideal for you. Heading away for a week or longer? Look into a rental car, hotel and flight bundle. If you're taking a short break, an airfare and hotel deal could suit you better. Activities can also be added after you've booked. Our vacation packages make it easy to save and plan.
What should I know before booking a Santa Cruz travel package?
Locking in all the parts of your trip together is an excellent way to save. Bundle your airfares, rental cars and hotels into a tidy package. But hotels aren't your only option. Expedia offers all types of properties, including vacation rentals such as beach villas and city residences. You've got loads of choices!
Can I choose my airline with a Santa Cruz Expedia vacation package?
Definitely. Expedia has over 550 airline partners to pick from around the globe. With such a big range of choice, finding the perfect carrier to fly you to Santa Cruz will be a breeze.
If I'm not able to travel, can I cancel my Santa Cruz vacation package?
Yes, you can. We totally understand that even the best-laid plans can go awry, so we're here to help if you need to make changes to your Santa Cruz vacation package. You may be able to amend or cancel your itinerary for free if you've booked within 24 hours. Your airline, hotel or car rental company may charge you a fee if you booked more than 24 hours ago. Have a look at our Customer Service Portal for more information. Also, be sure to check your itinerary for the finer details on change fees.

Popular places to visit

Arena Pantanal

Catch an event at Arena Pantanal during your trip to Cuiabá. Stroll along the riverfront or experience the area's museums.

Arena Pantanal

Ze Bolo Flo Park

Explore the great outdoors at Ze Bolo Flo Park, a lovely green space in Cuiabá. Discover the waterfalls while you're in the area.

Ze Bolo Flo Park

Antonio Pires de Campos Park

Explore the great outdoors at Antonio Pires de Campos Park, a lovely green space in Cuiabá. Stroll along the riverfront or experience the area's museums.

Antonio Pires de Campos Park

Things to do

8 Days Jaguars and Pantanal Safari tour

8 Days Jaguars and Pantanal Safari tour

P290,785
per adult
8 Days Jaguars and Pantanal Safari tour
See all activities in Cuiabá
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.