Weather will likely play an important role when you plan your trip to Santa Cruz Barillas, and keep in mind that cheaper options are usually available when the weather isn't as good. The hottest months are usually April and March with an average temp of 59°F, while the coldest months are January and December with an average of 55°F. The rainiest months in Santa Cruz Barillas are June, September, August, and July, with each month seeing an average of 22 inches of rainfall.