Hotels near Sanford USD Medical Center

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Dec 25 - Dec 26
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Dec 26 - Dec 27
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Dec 26 - Dec 28
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Jan 2 - Jan 4

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Our top choices for Sanford USD Medical Center hotels

Interior detail
Hotel On Phillips

Hotel On Phillips

Hotel On Phillips
2.5 star property
Downtown Sioux Falls, 1.8 km from Sanford USD Medical Center
9.6 out of 10, Exceptional, (1304)
"Great staff and location!"
United States
Gerald
Hotel On Phillips
Terrace/patio
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center
3.0 star property
University Heights, 0.1 km from Sanford USD Medical Center
9.4 out of 10, Exceptional, (586)
"This is a great hotel - centrally located and very clean and quiet. Will definitely be staying there again. "
United States
Tracey
The price is P5,887
P6,576 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center
Meeting facility
Canopy By Hilton Sioux Falls Downtown

Canopy By Hilton Sioux Falls Downtown

Canopy By Hilton Sioux Falls Downtown
4.0 star property
Downtown Sioux Falls, 2.4 km from Sanford USD Medical Center
9.4 out of 10, Exceptional, (159)
"Room was very clean, great overall stay."
United States
Destiny
The price is P7,657
P8,753 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Canopy By Hilton Sioux Falls Downtown
Free daily continental breakfast
Clubhouse Hotel Suites Sioux Falls

Clubhouse Hotel Suites Sioux Falls

Clubhouse Hotel Suites Sioux Falls
3.0 star property
Mall District, 2.9 km from Sanford USD Medical Center
9.4 out of 10, Exceptional, (1000)
"Absolutely beautiful places to stay with family excellent service staff great food service great hospitality great "
United States
Rosario
Clubhouse Hotel Suites Sioux Falls
Living area
Hilton Garden Inn Sioux Falls Downtown

Hilton Garden Inn Sioux Falls Downtown

Hilton Garden Inn Sioux Falls Downtown
3.0 star property
Downtown Sioux Falls, 2 km from Sanford USD Medical Center
9.0 out of 10, Wonderful, (889)
"Friendly front desk staff, clean room, great location, safe "
United States
Hannah
The price is P6,110
P7,055 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Hilton Garden Inn Sioux Falls Downtown
Porch
Historic Victorian Inn

Historic Victorian Inn

Historic Victorian Inn
3.0 star property
Cathedral, 1.4 km from Sanford USD Medical Center
8.8 out of 10, Excellent, (56)
"It was a great place to stay and super interesting."
United States
Kathy
The price is P6,394
P7,978 total
includes taxes & fees
Dec 26 - Dec 27
Historic Victorian Inn
Exterior
Holiday Inn Sioux Falls-City Centre by IHG

Holiday Inn Sioux Falls-City Centre by IHG

Holiday Inn Sioux Falls-City Centre by IHG
3.0 star property
Downtown Sioux Falls, 1.8 km from Sanford USD Medical Center
8.6 out of 10, Excellent, (1000)
"Always a great stay. "
United States
Shawn
The price is P5,110
P5,723 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Holiday Inn Sioux Falls-City Centre by IHG
Lobby
Sheraton Sioux Falls Hotel & Convention Center

Sheraton Sioux Falls Hotel & Convention Center

Sheraton Sioux Falls Hotel & Convention Center
4.0 star property
Northwest Sioux Falls, 2.8 km from Sanford USD Medical Center
8.6 out of 10, Excellent, (1000)
"Great hotel. Staff was excellent "
United States
Kristina
The price is P5,702
P6,373 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Sheraton Sioux Falls Hotel & Convention Center
Exterior
Country Inn & Suites by Radisson, Sioux Falls

Country Inn & Suites by Radisson, Sioux Falls

Country Inn & Suites by Radisson, Sioux Falls
3.0 star property
Downtown Sioux Falls, 1.9 km from Sanford USD Medical Center
8.4 out of 10, Very Good, (1161)
"It was a great place to stay!"
United States
Trinity
The price is P4,914
P5,508 total
includes taxes & fees
Dec 29 - Dec 30
Country Inn & Suites by Radisson, Sioux Falls
Free daily continental breakfast
The Center Inn

The Center Inn

The Center Inn
2.5 star property
All Saints, 2.3 km from Sanford USD Medical Center
8.4 out of 10, Very Good, (703)
"Room and staff were great. "
United States
Annette
The Center Inn
3 indoor pools, open 9:00 AM to 10:00 PM, sun loungers
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
3.0 star property
Northwest Sioux Falls, 2.9 km from Sanford USD Medical Center
7.8 out of 10, Good, (1458)
"staff was friendly "
United States
Rob
The price is P3,773
P4,256 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
Desk, free WiFi, wheelchair access
Valley Inn

Valley Inn

Valley Inn
2.5 star property
University Heights, 0.1 km from Sanford USD Medical Center
7.6 out of 10, Good, (1000)
"Room was clean, staff was friendly, very convenient location "
United States
Theresa
Valley Inn
Pool
Ramada by Wyndham Sioux Falls Arpt & Suites

Ramada by Wyndham Sioux Falls Arpt & Suites

Ramada by Wyndham Sioux Falls Arpt & Suites
2.0 star property
Northwest Sioux Falls, 2.9 km from Sanford USD Medical Center
7.0 out of 10, Good, (52)
"Very friendly at check in. Great service at bar."
United States
Chris
Ramada by Wyndham Sioux Falls Arpt & Suites
Lobby
Ramada by Wyndham Sioux Falls

Ramada by Wyndham Sioux Falls

Ramada by Wyndham Sioux Falls
2.0 star property
2.7 km from Sanford USD Medical Center
5.6 out of 10, (1000)
"Good room for the price."
United States
Michael
The price is P2,995
P3,403 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Ramada by Wyndham Sioux Falls
Dining room
Historic Twin Tudors Inn

Historic Twin Tudors Inn

Historic Twin Tudors Inn
3.0 star property
1.3 km from Sanford USD Medical Center
8.8 out of 10, Excellent, (3)
"Lovely place! Wish we could have stayed longer. Steve was attentive and helpful. "
United States
Anonymous traveler
The price is P15,805
P17,922 total
includes taxes & fees
Dec 29 - Dec 30
Historic Twin Tudors Inn
Terrace/patio
Hyatt Place Sioux Falls South

Hyatt Place Sioux Falls South

Hyatt Place Sioux Falls South
3.0 star property
Mall District, 3.8 km from Sanford USD Medical Center
9.4 out of 10, Exceptional, (1000)
"Great stay!"
United States
Nick
The price is P6,872
P7,656 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hyatt Place Sioux Falls South
Free cribs/infant beds, free WiFi, bed sheets
Staybridge Suites Sioux Falls Southwest by IHG

Staybridge Suites Sioux Falls Southwest by IHG

Staybridge Suites Sioux Falls Southwest by IHG
3.0 star property
South Sioux Falls, 5.3 km from Sanford USD Medical Center
9.6 out of 10, Exceptional, (458)
"Staff was great, all very friendly. Room was very clean, and we had a great nights sleep. "
United States
Eric
The price is P5,296
P5,928 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Staybridge Suites Sioux Falls Southwest by IHG
Desk, laptop workspace, soundproofing, iron/ironing board
Comfort Inn & Suites at Sanford Sports Complex

Comfort Inn & Suites at Sanford Sports Complex

Comfort Inn & Suites at Sanford Sports Complex
2.5 star property
Northwest Sioux Falls, 6 km from Sanford USD Medical Center
9.6 out of 10, Exceptional, (903)
"Perfect stay. This is what clean, quiet and convenient looks like at an affordable price. "
United States
Tiffany
The price is P5,560
P6,217 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Comfort Inn & Suites at Sanford Sports Complex
Lobby sitting area
Comfort Inn & Suites Avera Southwest

Comfort Inn & Suites Avera Southwest

Comfort Inn & Suites Avera Southwest
2.5 star property
South Sioux Falls, 5.6 km from Sanford USD Medical Center
9.4 out of 10, Exceptional, (1006)
"Everything was great during our stay. I would definitely stay there again. "
United States
Brandolyn
The price is P6,165
P6,880 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Comfort Inn & Suites Avera Southwest
Front of property - evening/night
Hampton Inn Sioux Falls

Hampton Inn Sioux Falls

Hampton Inn Sioux Falls
2.5 star property
Mall District, 3.2 km from Sanford USD Medical Center
9.2 out of 10, Wonderful, (1009)
"It was a very nice stay. "
United States
Lenore
The price is P5,742
P6,417 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Hampton Inn Sioux Falls
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Sanford USD Medical Center Hotel Reviews

AeroStay Hotel

AeroStay Hotel

10/10 Excellent
"VERY CLEAN ROOM, FRIENDLY AND HELPFUL STAFF, ADEQUATE BREAKFAST"
DUANE 1-night trip
Posted 1 day ago
AeroStay Hotel

Hotels near other Sanford USD Medical Center attractions

Sioux Empire Medical Museum

You can spend time studying the exhibits at Sioux Empire Medical Museum in Sioux Falls. In the area, take in the entertainment choices and beautiful waterfalls.
See properties

University of Sioux Falls

4.1/5 (170 reviews)
Take a campus tour or just explore the area of University of Sioux Falls, during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.
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Frequently asked questions

What's the area like around Sanford USD Medical Center?
Sanford USD Medical Center is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, check out the 110 hotels and other accommodations you'll find within a mile.
Where is the best place to stay close to Sanford USD Medical Center?
Adjacent to Sanford USD Medical Center, Home2 Suites By Hilton Sioux Falls/Sanford Medical Center is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. Another good choice is Valley Inn, located just 0.1 mi (0.1 km) away.
How many hotels should I expect to find close to Sanford USD Medical Center?
Expedia has 110 hotels and other accommodations within a mile from Sanford USD Medical Center.
If I need to cancel the hotel reservation for my stay near Sanford USD Medical Center, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to get the best deals available near Sanford USD Medical Center.
What can I see and do near Sanford USD Medical Center?
Study the collections at Washington Pavilion of Arts and Science, Center for Western Studies, or Old Courthouse Museum. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. Local parks like Falls Park, Fawick Park, and Sherman Park are peaceful spots to stop and take in some fresh air.