San Cosme y Damian Hotels

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
May 22 - May 24
Next weekend
May 29 - May 31

Filter by

Guest rating
Guest rating
Star rating
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular San Cosme y Damian attractions

Guarani Jesuit Ruins of San Cosme and San Damián

Find out about the history of San Cosme y Damian when you take a trip to Guarani Jesuit Ruins of San Cosme and San Damián. Take in the museums while you're in the area.
See properties

Top San Cosme y Damian Hotel Reviews

More cheap stays in San Cosme y Damian

Hotel Puesta del Sol

Hotel Puesta del Sol

14 de Mayo 44 Esq. Av. Francia Encarnacion Itapua
The price is P3,001 per night from May 20 to May 21
P3,001
P3,301 total
May 20 - May 21
includes taxes & fees

Frequently asked questions

If I need to cancel my hotel reservation in San Cosme y Damian, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of check in. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in San Cosme y Damian.
What are the top places to visit in San Cosme y Damian?
A couple of favorite places to visit are Guarani Jesuit Ruins of San Cosme and San Damián and Buenaventura Suarez Planetarium. Check out what more to see and do in Expedia's San Cosme y Damian guide.
What's the weather like in San Cosme y Damian?
The hottest months are usually January and February with an average temp of 80°F, while the coldest months are July and June with an average of 62°F. The rainiest months in San Cosme y Damian are October, November, May, and April, with each month seeing an average of 8 inches of rainfall.