A night scene with a clear sky, a crescent moon, and two silhouetted trees against a twilight sky.

Puxico Hotels

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Check prices for these dates

Tonight
Aug 28 - Aug 29
Tomorrow
Aug 29 - Aug 30
This weekend
Aug 28 - Aug 30
Next weekend
Sep 4 - Sep 6

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Our top choices for Puxico hotels

1. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
Poplar Bluff
United States
Arsenia
P6,257
P7,068 total
includes taxes & fees
Sep 7 - Sep 8
Fairfield Inn & Suites by Marriott Poplar Bluff

2. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
Poplar Bluff
United States
Philip
P5,782
P6,475 total
includes taxes & fees
Sep 13 - Sep 14
Hampton Inn Poplar Bluff

3. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
Poplar Bluff
United States
Paul
P6,287
P7,103 total
includes taxes & fees
Sep 6 - Sep 7
Drury Inn & Suites Poplar Bluff

4. Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
Poplar Bluff
United States
Kathleen
P4,870
P5,454 total
includes taxes & fees
Aug 30 - Aug 31
Motel 6 Poplar Bluff, MO

5. Econo Lodge Dexter

Econo Lodge Dexter
Dexter
United States
Herman
P3,143
P3,530 total
includes taxes & fees
Sep 26 - Sep 27
Econo Lodge Dexter

6. Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
Dexter
United States
Steven
P5,344
P6,001 total
includes taxes & fees
Sep 17 - Sep 18
Travelodge by Wyndham Dexter

7. Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
Dexter
United States
Joyce
P6,015
P6,755 total
includes taxes & fees
Sep 7 - Sep 8
Hampton Inn By Hilton Dexter

8. Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
Poplar Bluff
United States
Paige
P5,178
P5,850 total
includes taxes & fees
Sep 13 - Sep 14
Holiday Inn Poplar Bluff by IHG

9. Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri
Poplar Bluff
United States
Diana
P3,405
P3,838 total
includes taxes & fees
Sep 10 - Sep 11
Super 8 by Wyndham Poplar Bluff Missouri

10. Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North
Poplar Bluff
United States
Muhammad
P4,983
P5,630 total
includes taxes & fees
Sep 20 - Sep 21
Comfort Inn Poplar Bluff North

11. Lake Wappapello

Lake Wappapello
Williamsville
United States
Tonya
P5,548
P5,852 total
includes taxes & fees
Aug 29 - Aug 30
Lake Wappapello

12. Dexter Inn

Dexter Inn
Dexter
United States
Edward
P4,021
P4,515 total
includes taxes & fees
Aug 30 - Aug 31
Dexter Inn

13. OYO Hickory House Inn

OYO Hickory House Inn
Dexter
United States
Tammy
P2,806
P3,433 total
includes taxes & fees
Sep 27 - Sep 28
OYO Hickory House Inn

14. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
Marble Hill
United States
JANEEN
P6,240
P6,793 total
includes taxes & fees
Aug 29 - Aug 30
EC Reed's Mercantile and Hotel
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Learn more about Puxico

Check out the local area in Puxico—home to attractions like Mark Twain National Forest and Mingo Wilderness.

See all hotels in Puxico
A night scene with a clear sky, a crescent moon, and two silhouetted trees against a twilight sky.
Photo by Mike McClain

Top Puxico Hotel Reviews

Dexter Inn

Dexter Inn

8/10 Good
"breakfast was good, staff friendly, pool area needs work"
Edward 2-night trip
Posted 1 day ago
Dexter Inn
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

10/10 Excellent
"loved it!!!"
George 1-night trip
Posted 3 days ago
Fairfield Inn & Suites by Marriott Poplar Bluff
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

10/10 Excellent
"We travel frequently and this is a place we have enjoyed when in this area. We have stayed here several times"
Garth 1-night trip
Posted 5 days ago
Hampton Inn Poplar Bluff
EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel

10/10 Excellent
"Great place! Room was nice and there breakfast in the mercantile was top notch!"
Drew 1-night trip
Posted 5 days ago
EC Reed's Mercantile and Hotel
Econo Lodge Dexter

Econo Lodge Dexter

10/10 Excellent
"Staff are kind, welcoming and helpful! Property is clean and well. For the pri"
Elizabeth 1-night trip
Posted 5 days ago
Econo Lodge Dexter
Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter

10/10 Excellent
"Best Hampton Inn that I have ever stayed in. Excellent service and Wonderful staff. Extremely helpful with disabled husband."
Stephen 2-night trip
Posted 8 days ago
Hampton Inn By Hilton Dexter
Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter

10/10 Excellent
"It’s was clean and very well maintained"
Larry 1-night trip
Posted 11 days ago
Travelodge by Wyndham Dexter
OYO Hickory House Inn

OYO Hickory House Inn

10/10 Excellent
"Nice for overnight stop"
Tammy 1-night trip
Posted 1 month ago
OYO Hickory House Inn

More cheap stays in Puxico

Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri

2831 N Westwood Blvd Poplar Bluff MO
P3,405
P3,838 total
Sep 10 - Sep 11
includes taxes & fees
Super 8 by Wyndham Poplar Bluff Missouri
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO
P4,870
P5,454 total
Aug 30 - Aug 31
includes taxes & fees
8/10 Very Good! (1,000 reviews)
Motel 6 Poplar Bluff, MO
Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North

2582 N Westwood Blvd Poplar Bluff MO
P4,983
P5,630 total
Sep 20 - Sep 21
includes taxes & fees
7.8/10 Good! (436 reviews)
Comfort Inn Poplar Bluff North
Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter

1608 E Business US 60 Dexter MO
P5,344
P6,001 total
Sep 17 - Sep 18
includes taxes & fees
7.6/10 Good! (420 reviews)
Travelodge by Wyndham Dexter
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO
P5,782
P6,475 total
Sep 13 - Sep 14
includes taxes & fees
9.4/10 Exceptional! (921 reviews)
Hampton Inn Poplar Bluff
Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter

2179 Gill Plaza Drive Dexter MO
P6,015
P6,755 total
Sep 7 - Sep 8
includes taxes & fees
9.8/10 Exceptional! (66 reviews)
Hampton Inn By Hilton Dexter

Frequently asked questions

What's the best place for a stay in Puxico?
Motel 6 Poplar Bluff, MO, located 19.4 mi (31.3 km) from the heart of Puxico, is a top choice for your stay based on our traveler data. Two other choices for your trip to the area are Fairfield Inn & Suites by Marriott Poplar Bluff and Drury Inn & Suites Poplar Bluff. See all available top hotels, or vacation rentals in Puxico.
If I need to cancel my hotel reservation in Puxico, will I receive a refund?
Yes, you'll find most hotel bookings are refundable provided that you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Puxico.
What is staying in Puxico like?
Travelers to Puxico will find plenty to explore and enjoy. There are 56 hotels and other accommodations in the surrounding area. Find out more about Puxico.
What is there to see in Puxico?
A couple of favorite places to visit are Mark Twain National Forest and Mingo Wilderness. You'll also find Lake Wappapello and Mo-Ark Regional Railroad Museum in the area. Check out what more to see and do in Expedia's Puxico guide.
What's the seasonal weather like in Puxico?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Puxico is 59 inches.

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