Hotels near Odessa Regional Medical Center

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Our top choices for Odessa Regional Medical Center hotels

Outdoor pool, open 10:00 AM to 10:00 PM, cabanas (surcharge)
Odessa Marriott Hotel & Conference Center

Odessa Marriott Hotel & Conference Center

Odessa Marriott Hotel & Conference Center
4.0 star property
0.2 km from Odessa Regional Medical Center
9.2 out of 10, Wonderful, (467)
"Rooms and hotel were great"
United States
John
The price is P10,454
P12,023 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Odessa Marriott Hotel & Conference Center
Free breakfast
Holiday Inn Express & Suites Odessa I-20 by IHG

Holiday Inn Express & Suites Odessa I-20 by IHG

Holiday Inn Express & Suites Odessa I-20 by IHG
2.5 star property
3.1 km from Odessa Regional Medical Center
8.8 out of 10, Excellent, (470)
"Room was nicely cleaned & staff was very polite. "
United States
Mariano
The price is P5,826
P6,768 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Holiday Inn Express & Suites Odessa I-20 by IHG
Lobby
Motel 6 Odessa, TX - 2nd Street

Motel 6 Odessa, TX - 2nd Street

Motel 6 Odessa, TX - 2nd Street
2.0 star property
1.9 km from Odessa Regional Medical Center
7.8 out of 10, Good, (502)
"Te staff was rude at check in and seem to have an issue with two men checking in."
United States
Michael
The price is P3,529
P4,058 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Motel 6 Odessa, TX - 2nd Street
Desk, laptop workspace, blackout drapes, iron/ironing board
MainStay Suites Odessa I-20

MainStay Suites Odessa I-20

MainStay Suites Odessa I-20
2.5 star property
3 km from Odessa Regional Medical Center
8.2 out of 10, Very Good, (300)
"Very clean very spacious rooms friendly staff loved it"
United States
Jamayea
The price is P4,415
P5,077 total
includes taxes & fees
Jan 11 - Jan 12, 2026
MainStay Suites Odessa I-20
View from room
SureStay Plus Hotel by Best Western Odessa

SureStay Plus Hotel by Best Western Odessa

SureStay Plus Hotel by Best Western Odessa
3.0 star property
2.7 km from Odessa Regional Medical Center
7.4 out of 10, Good, (78)
"Very nice place to stay "
United States
Jerry
The price is P4,941
P5,682 total
includes taxes & fees
Jan 1 - Jan 2, 2026
SureStay Plus Hotel by Best Western Odessa
Rollaway beds, free WiFi
Villa West Inn

Villa West Inn

Villa West Inn
2.0 star property
2.6 km from Odessa Regional Medical Center
7.4 out of 10, Good, (178)
"Clean room, clean toilet and good staffs."
United States
Francis
The price is P3,529
P4,059 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Villa West Inn
Living area
DELUX INN

DELUX INN

DELUX INN
2.5 star property
2.5 km from Odessa Regional Medical Center
6.8 out of 10, (24)
"Best hotel "
United States
Poncho
The price is P3,824
P4,397 total
includes taxes & fees
Jan 1 - Jan 2, 2026
DELUX INN
Blackout drapes, free WiFi, bed sheets
Motel 6 Odessa, TX

Motel 6 Odessa, TX

Motel 6 Odessa, TX
2.0 star property
2.8 km from Odessa Regional Medical Center
6.8 out of 10, (553)
"The room was very clean. And management was very helpful."
United States
Bonnie
The price is P3,764
P4,329 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Motel 6 Odessa, TX
Children's area
Staybridge Suites Odessa - Interstate HWY 20 by IHG

Staybridge Suites Odessa - Interstate HWY 20 by IHG

Staybridge Suites Odessa - Interstate HWY 20 by IHG
3.0 star property
4.6 km from Odessa Regional Medical Center
8.8 out of 10, Excellent, (144)
"Excellent "
United States
Jeannette
The price is P4,649
P5,346 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Staybridge Suites Odessa - Interstate HWY 20 by IHG
Seasonal outdoor pool, open 7:00 AM to 10:00 PM, sun loungers
Hawthorn Extended Stay by Wyndham Odessa

Hawthorn Extended Stay by Wyndham Odessa

Hawthorn Extended Stay by Wyndham Odessa
3.5 star property
4.7 km from Odessa Regional Medical Center
8.6 out of 10, Excellent, (269)
"Clean room, reasonable price and restaurant on site which was perfect after a long day of driving"
United States
Kimberly
The price is P5,241
P6,027 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Hawthorn Extended Stay by Wyndham Odessa
Property amenity
Candlewood Suites Odessa by IHG

Candlewood Suites Odessa by IHG

Candlewood Suites Odessa by IHG
2.5 star property
4.6 km from Odessa Regional Medical Center
8.6 out of 10, Excellent, (190)
"It was a smaller place than i have stayed before, it does not have a pool, but still great place to stay."
United States
Alice
The price is P4,950
P5,692 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Candlewood Suites Odessa by IHG
Desk, laptop workspace, blackout drapes, iron/ironing board
Sleep Inn & Suites Odessa near University

Sleep Inn & Suites Odessa near University

Sleep Inn & Suites Odessa near University
2.5 star property
5.2 km from Odessa Regional Medical Center
8.6 out of 10, Excellent, (466)
"Very good"
United States
Sharmin
The price is P3,750
P4,313 total
includes taxes & fees
Jan 23 - Jan 24, 2026
Sleep Inn & Suites Odessa near University
Exterior
Fairfield Inn & Suites Odessa

Fairfield Inn & Suites Odessa

Fairfield Inn & Suites Odessa
2.5 star property
5.3 km from Odessa Regional Medical Center
8.8 out of 10, Excellent, (412)
"The rooms were clean and spacious. And the free breakfast was the best! I would totally stay here again. "
United States
Tina
The price is P5,473
P6,430 total
includes taxes & fees
Jan 16 - Jan 17, 2026
Fairfield Inn & Suites Odessa
Lobby
Sonesta Essential Hotels Odessa

Sonesta Essential Hotels Odessa

Sonesta Essential Hotels Odessa
2.0 star property
4.3 km from Odessa Regional Medical Center
7.8 out of 10, Good, (752)
"Nice place"
United States
Jose
The price is P3,950
P4,543 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Sonesta Essential Hotels Odessa
Full-size fridge, microwave
Parkway Inn

Parkway Inn

Parkway Inn
2.0 star property
5 km from Odessa Regional Medical Center
8.4 out of 10, Very Good, (35)
"The cleanliness, tv and bed was awesome "
United States
Ellie
The price is P3,707
P4,264 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Parkway Inn
View from room
MCM Elegante Hotel and Conference Center Odessa

MCM Elegante Hotel and Conference Center Odessa

MCM Elegante Hotel and Conference Center Odessa
3.5 star property
6 km from Odessa Regional Medical Center
9.0 out of 10, Wonderful, (1006)
"incredible stay at a 5 star hotel in Odessa Texas. Room was clean; Staff was excellent; Food was delicious. was pleasantly surprised. will stay out there again while visiting family & friends!"
United States
Patricia
The price is P5,886
P6,768 total
includes taxes & fees
Jan 1 - Jan 2, 2026
MCM Elegante Hotel and Conference Center Odessa
Full-size fridge, microwave, stovetop, coffee/tea maker
Studio 6 Odessa, TX

Studio 6 Odessa, TX

Studio 6 Odessa, TX
2.5 star property
4.6 km from Odessa Regional Medical Center
8.0 out of 10, Very Good, (243)
"This property puts several others. I’ve stayed in Odessa to shame. This is a nice property. The rooms are clean and spacious that I’ve been in. There was a door that didn’t open particularly easy in room 102 but that didn’t really interfere with my trip at all. I would stay at this facility again."
United States
JIMMY
The price is P4,705
P5,411 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Studio 6 Odessa, TX
Outdoor pool
Hampton Inn by Hilton Odessa

Hampton Inn by Hilton Odessa

Hampton Inn by Hilton Odessa
2.5 star property
5.3 km from Odessa Regional Medical Center
8.6 out of 10, Excellent, (369)
"Always a great place to stay!!!"
United States
Xavier
The price is P5,499
P6,387 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Hampton Inn by Hilton Odessa
Lobby
Comfort Inn & Suites, Odessa I-20

Comfort Inn & Suites, Odessa I-20

Comfort Inn & Suites, Odessa I-20
2.5 star property
4.6 km from Odessa Regional Medical Center
7.8 out of 10, Good, (571)
"Room was clean and comfortable "
United States
Dolores
The price is P4,405
P5,066 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Comfort Inn & Suites, Odessa I-20
Restaurant
MCM Grande Hotel FunDome Odessa

MCM Grande Hotel FunDome Odessa

MCM Grande Hotel FunDome Odessa
3.0 star property
6.4 km from Odessa Regional Medical Center
8.6 out of 10, Excellent, (1244)
"Thanks to God we had an amazing time "
United States
Ar'Letha
The price is P4,242
P4,879 total
includes taxes & fees
Jan 11 - Jan 12, 2026
MCM Grande Hotel FunDome Odessa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Odessa Regional Medical Center Hotel Reviews

MCM Grande Hotel FunDome Odessa

MCM Grande Hotel FunDome Odessa

10/10 Excellent
"Everything stood out, thanks to God of course!! "
Edward 1-night trip
Posted 6 days ago
MCM Grande Hotel FunDome Odessa

Hotels near other Odessa Regional Medical Center attractions

Odessa Jackrabbit Statue

You can learn about the history of Odessa with a trip to Odessa Jackrabbit Statue. While in this family-friendly area, you can savor the top-notch restaurants.
See properties

White-Pool House

4.3/5 (20 reviews)
You can find out about the history of Odessa with a visit to White-Pool House. Experience the area's entertainment venues or attend a sporting event.
See properties

Frequently asked questions

What's the area like around Odessa Regional Medical Center?
Odessa Regional Medical Center is located in Odessa. This family-friendly area is known for its array of dining options. If you're looking for a convenient place to stay, check out the 15 hotels and other accommodations you'll find within a mile.
What's the best hotel to stay close to Odessa Regional Medical Center?
Adjacent to Odessa Regional Medical Center, Odessa Marriott Hotel & Conference Center is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices within a few miles include MCM Grande Hotel FunDome Odessa and MCM Elegante Hotel and Conference Center Odessa.
How many hotels can I expect to find near Odessa Regional Medical Center?
Expedia has 15 hotels and other accommodations within a mile from Odessa Regional Medical Center.
If I need to cancel the hotel reservation for my stay near Odessa Regional Medical Center, will I receive a refund?
Yes! Most hotel reservations are refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you have a reservation that's non-refundable, it might still be possible to cancel it and receive a refund within 24 hours of booking. Add dates, click "Search", then use the "fully refundable" filter to view the top deals on offer near Odessa Regional Medical Center.
What can I see and do near Odessa Regional Medical Center?
Study the collections at White-Pool House, Ellen Noel Art Museum, or Parker House Museum. Create some family memories at Altitude Trampoline Park and Fun City. Attractions like Globe of the Great Southwest and Presidential Museum and Leadership Library highlight the local culture.