A large eye sculpture in a park surrounded by trees.

Northeast Missouri Hotels

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Oct 5 - Oct 6
Tomorrow
Oct 6 - Oct 7
This weekend
Oct 9 - Oct 11
Next weekend
Oct 16 - Oct 18

Filter by

Star rating

Guest rating

Our top choices for Northeast Missouri hotels

1. Depot Inn and Suites

Depot Inn and Suites
La Plata
United States
JERROD
P5,718
P6,196 total
includes taxes & fees
Oct 25 - Oct 26
Depot Inn and Suites

2. Best Western On The River

Best Western On The River
Hannibal
United States
Raymond
P6,880
P7,936 total
includes taxes & fees
Oct 6 - Oct 7
Best Western On The River

3. Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
Hannibal
United States
Patricia
P6,678
P7,770 total
includes taxes & fees
Nov 2 - Nov 3
Sleep Inn & Suites Hannibal West

4. Hampton Inn Kirksville

Hampton Inn Kirksville
Kirksville
United States
Phillip
P7,595
P8,607 total
includes taxes & fees
Oct 11 - Oct 12
Hampton Inn Kirksville

5. Comfort Inn Sullivan

Comfort Inn Sullivan
Sullivan
United States
Cherie
P7,125
P7,764 total
includes taxes & fees
Oct 25 - Oct 26
Comfort Inn Sullivan

6. Super 8 by Wyndham Kirksville-University Area

Super 8 by Wyndham Kirksville-University Area
Kirksville
United States
David
P4,879
P5,481 total
includes taxes & fees
Oct 6 - Oct 7
Super 8 by Wyndham Kirksville-University Area

7. Pinemark Inn & Suites

Pinemark Inn & Suites
St. Clair
United States
John
P8,409
P9,206 total
includes taxes & fees
Nov 1 - Nov 2
Pinemark Inn & Suites

8. Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
Hannibal
United States
Gayle
P4,745
P5,521 total
includes taxes & fees
Nov 1 - Nov 2
Quality Inn & Suites Hannibal West

9. Oak Hill Inn & Suites

Oak Hill Inn & Suites
Canton
United States
Marie
P6,333
P7,218 total
includes taxes & fees
Oct 18 - Oct 19
Oak Hill Inn & Suites

10. Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
Washington
United States
Shawn
P8,069
P9,187 total
includes taxes & fees
Oct 11 - Oct 12
Best Western Plus Washington Hotel

11. Quality Inn & Suites Quincy - Downtown

Quality Inn & Suites Quincy - Downtown
Quincy
United States
Sandra
P7,725
P8,805 total
includes taxes & fees
Oct 11 - Oct 12
Quality Inn & Suites Quincy - Downtown

12. Baymont by Wyndham Sullivan

Baymont by Wyndham Sullivan
Sullivan
United States
Peggy
P6,868
P7,485 total
includes taxes & fees
Nov 2 - Nov 3
Baymont by Wyndham Sullivan

13. Hampton Inn By Hilton Warrenton I-70

Hampton Inn By Hilton Warrenton I-70
Warrenton
United States
Kaiyla
P8,198
P9,364 total
includes taxes & fees
Nov 1 - Nov 2
Hampton Inn By Hilton Warrenton I-70

14. Holiday Inn Express & Suites St Peters by IHG

Holiday Inn Express & Suites St Peters by IHG
St. Peters
United States
Serah
P7,381
P8,871 total
includes taxes & fees
Oct 25 - Oct 26
Holiday Inn Express & Suites St Peters by IHG

15. Travelier Motel

Travelier Motel
Macon
United States
Jessica
P4,379
P5,215 total
includes taxes & fees
Oct 6 - Oct 7
Travelier Motel

16. Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis
Valley Park
United States
Randy
P7,193
P8,415 total
includes taxes & fees
Oct 11 - Oct 12
Drury Inn & Suites Southwest St. Louis

17. Super 8 by Wyndham Washington

Super 8 by Wyndham Washington
Washington
United States
Kenneth
P5,292
P6,025 total
includes taxes & fees
Oct 11 - Oct 12
Super 8 by Wyndham Washington

18. Comfort Inn Near Six Flags St. Louis

Comfort Inn Near Six Flags St. Louis
Pacific
United States
Gail
P6,072
P6,951 total
includes taxes & fees
Oct 26 - Oct 27
Comfort Inn Near Six Flags St. Louis

19. Best Western Plus Fenton

Best Western Plus Fenton
Fenton
United States
Brian
P6,062
P7,001 total
includes taxes & fees
Oct 7 - Oct 8
Best Western Plus Fenton

20. Hyatt Place St. Louis/Chesterfield

Hyatt Place St. Louis/Chesterfield
Chesterfield
United States
Shane
P7,544
P8,750 total
includes taxes & fees
Oct 18 - Oct 19
Hyatt Place St. Louis/Chesterfield
View all properties

Vacation Rentals in Northeast Missouri

Cabin

Cannon Dam Cabins

Cannon Dam Cabins
Perry
"Amazing place to stay! You can’t beat the indoor pool whether it is storming or feels like the fires from hell are raining on earth you can still enjoy a great swim without worrying about lightning or burning to death. The people are incredibly kind and on top of anything you may need and the cabins are a perfect relaxing get away with nice a/c and plenty of sleeping space! Thank you for another amazing stay!"
Cannon Dam Cabins
Aparthotel

Lighthouse Inn & Suites

Lighthouse Inn & Suites
Hannibal
"Wonderful place to stay!"
Lighthouse Inn & Suites
Aparthotel

The Mercantile on the Katy Trail

The Mercantile on the Katy Trail
Hermann
"It’s an absolute must do! Such a cool little town right on the Katy Trail!"
The Mercantile on the Katy Trail
Cottage

Peaceful Missouri Cabin Rental on 55 Acres!

Peaceful Missouri Cabin Rental on 55 Acres!
Canton
"This is a great place to stay if you want to get away from the city. Rural enough to be quiet, but within easy driving distance to a city. Also perfect if you just want to stay on the property and really get away from city life, just bring your groceries. "
Peaceful Missouri Cabin Rental on 55 Acres!
Apartment

Spacious 3-Bedroom with King Bed

Spacious 3-Bedroom with King Bed
Central West End
"Clean room nice area "
Spacious 3-Bedroom with King Bed
Apartment

White House at Grand Central

White House at Grand Central
Grand Center
"Nice find in the city"
White House at Grand Central
Apartment

Landing Furnished Apartments - Central West End

Landing Furnished Apartments - Central West End
Central West End
"Parking was behind a large mechanical gate which did not always work. Could sometimes be noisy outside in the evening due to college clientele. Had to park on the street most of the time because of gate issues."
Landing Furnished Apartments - Central West End
Vacation Home

Remodeled and Inviting Free EV

Remodeled and Inviting Free EV
Fenton
"It was nice to stay for a weekend but the neighborhood was nice I like the location where it wasn't too far from grocery stores food areas the only thing I was saying is it's nothing for the kids to do but overall I like it"
Remodeled and Inviting Free EV
Cottage

Updated Missouri Cabin Rental on Large Farm

Updated Missouri Cabin Rental on Large Farm
Canton
"The cabin rental was a great stay. Had some connection problems with the t.v. couldn't get past the check out date. The wifi was easy to hook up. The cabin was clean and smelled fresh. Did have some problems with ants on the countertop. Great place to stay, enjoyed our visit."
Updated Missouri Cabin Rental on Large Farm
Apartment

Charming Berger Apt on 42-acre Farm w/ Pool Access

Charming Berger Apt on 42-acre Farm w/ Pool Access
Berger
Charming Berger Apt on 42-acre Farm w/ Pool Access
Apartment

Lakefront Studio Guest Home on Hermann Wine Trail!

Lakefront Studio Guest Home on Hermann Wine Trail!
New Haven
"Loved this property, very clean and well kept! Very pretty, lovely view. "
Lakefront Studio Guest Home on Hermann Wine Trail!
Cottage

Hillside Cabin on 43 Acres w/ Private Lake & View!

Hillside Cabin on 43 Acres w/ Private Lake & View!
Defiance
"We had a wonderful stay. The property is beautiful and well maintained, and the cabin is cute, comfortable, and well equipped. Nick is a very courteous host. We couldn’t have hoped for a better Thanksgiving getaway!"
Hillside Cabin on 43 Acres w/ Private Lake & View!
Apartment

The Merlot Bungalow Defiance Tiny Home on Trail

The Merlot Bungalow Defiance Tiny Home on Trail
Defiance
"We enjoyed our stay very much! The place was very cute and conveniently located to explore Defiance! We will look to stay here again in the future!"
The Merlot Bungalow Defiance Tiny Home on Trail
Cottage

Peaceful Guest Home w/ Patio on 152-acre Farm

Peaceful Guest Home w/ Patio on 152-acre Farm
Berger
"Very clean,family friendly, even though it was 7 miles out of town they were very Accommodating,they came to puck us up at the train station and there's a van that will take you into town and you can take the trolley to all the wineries,shopping, we all loved our stay,i would definitely recommend to anyone who enjoys the fram life, they have lots of history, and animals, thank you Susan and Mike for all that you did to make our stay memorable, we would definitely come back. "
Peaceful Guest Home w/ Patio on 152-acre Farm
Cottage

St Louis Home < 1 Mi to Forest Park!

St Louis Home < 1 Mi to Forest Park!
Dogtown
"We really enjoyed our stay. A great house in a really fun residential area. Close to an area with a main town st with cool restaurants, bars and shops to walk around. "
St Louis Home < 1 Mi to Forest Park!
See all vacation rentals
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Northeast Missouri attractions

The Saint Louis Zoo sign with vines on the wall.

St. Louis Zoo

9.2/10 (4,367 reviews)
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
See properties
A cityscape with a prominent statue in the center, surrounded by various buildings and a large stadium.

Enterprise Center

8.8/10 (1,597 reviews)
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
See properties
A baseball stadium with a large crowd, a prominent arch structure, and various advertisements.
Photo by Carl Guttovz

Busch Stadium

9.4/10 (4,850 reviews)
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
See properties
A cityscape with a prominent arch structure, various high-rise buildings, and a large government building.

Dome at America’s Center

8.4/10 (1,229 reviews)
Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's fascinating museums and acclaimed art scene.
See properties
A stone fountain with water cascading down a tiered structure, surrounded by a pond and a grassy area with a building in the background.

Forest Park

9.2/10 (3,389 reviews)
Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.
See properties
A historic building with a large lawn, a flagpole with flags, and a clear blue sky.

St. Louis University

8.6/10 (526 reviews)
Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its acclaimed theater scene.
See properties
A tightrope walker balancing on a wire between buildings.

City Museum

9.0/10 (3,209 reviews)
A rooftop Ferris wheel, an indoor tree house and a life-size, walk-through model of a whale; just some of the exhibits in this one-of-a-kind children's museum.
See properties

America's Center Convention Complex

8.8/10 (306 reviews)
Learn about the events happening at America's Center Convention Complex during your trip to St. Louis. Experience the area's acclaimed art scene and great live music.
See properties

Learn more about Northeast Missouri

Great live music, sports teams, and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theaters.

See all hotels in Northeast Missouri
A large eye sculpture in a park surrounded by trees.
Photo by Andrew Hershfeld

Top Northeast Missouri Hotel Reviews

Moonrise Hotel

Moonrise Hotel

8/10 Good
"The sheets were stained and dirty, the bed was not well made. The staff at reception, especially Nina, are amazing and extremely helpful!! I wish the hotel were tidier and lobby furniture freshened up some, the location is ideal!"
Thomas 1-night trip
Posted 7 hours ago
Moonrise Hotel
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

10/10 Excellent
"We had a pleasant stay here. Lots to do nearby. Would recommend."
Cassandra 2-night trip
Posted 7 hours ago
Pear Tree Inn St. Louis Airport
Drury Plaza Hotel St. Louis Union Station

Drury Plaza Hotel St. Louis Union Station

10/10 Excellent
"The room was very clean and well-maintained. Staff was friendly and the amenities were very generous. Beautiful historical hotel. Close to the Aquarium and various restaurants."
Juan J. 2-night trip
Posted 7 hours ago
Drury Plaza Hotel St. Louis Union Station
Home2 Suites by Hilton St. Louis Downtown

Home2 Suites by Hilton St. Louis Downtown

10/10 Excellent
"Great location Downtown. Staff were great. Parking on street is fine."
Bobby 1-night trip
Posted 9 hours ago
Home2 Suites by Hilton St. Louis Downtown
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

10/10 Excellent
"Easy parking, friendly staff, and large rooms were the highlights of Ameristar. I picked this hotel for my last night in St. Louis before a depressingly early flight. At 10 minutes to the airport, it was a very easy morning. The casino was an added bonus, giving me a way to unwind before my time home. Unfortunately, it is extremely smoky from the moment you get off the elevator from the parking garage. Even on the non-smoking floor of the casino, there is no refuge from the cigarette smell. That was to be expected though, and my non-smoking room was clean and unexpectedly large with a sunken living room and view of a body of water that I'm too lazy to look up."
Scott 1-night trip
Posted 17 hours ago
Ameristar Casino Resort and Spa
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

10/10 Excellent
"Clean and quiet place to walk from a concert at the theater. No drinking and driving"
Gregory 1-night trip
Posted 19 hours ago
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
The West End

The West End

10/10 Excellent
"Great service, front desk very helpful and since I had a procedure at BJU there was free parking in there garage. No breakfast though. And would love to have had a recliner in the room but will be back."
Starla 1-night trip
Posted 2 days ago
The West End
Tru By Hilton St. Louis Downtown

Tru By Hilton St. Louis Downtown

8/10 Good
"As a standard practice they only clean the room every other day. The coffee at breakfast is always old."
Nancy 3-night trip
Posted 2 days ago
Tru By Hilton St. Louis Downtown

More cheap stays in Northeast Missouri

Best Western St. Louis Inn

Best Western St. Louis Inn

6224 Heimos Industrial Park Dr St. Louis MO
P4,954
P5,697 total
Oct 12 - Oct 13
includes taxes & fees
8.4/10 Very Good! (1,162 reviews)
Best Western St. Louis Inn
Tru By Hilton St. Louis Downtown

Tru By Hilton St. Louis Downtown

1221 Locus Street St. Louis MO
P5,591
P6,537 total
Nov 1 - Nov 2
includes taxes & fees
Tru By Hilton St. Louis Downtown
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

10810 Pear Tree Ln St. Ann MO
P5,629
P6,628 total
Oct 11 - Oct 12
includes taxes & fees
9.2/10 Wonderful! (3,280 reviews)
Pear Tree Inn St. Louis Airport
The West End

The West End

4215 Lindell Blvd St. Louis MO
P5,187
P7,316 total
Oct 6 - Oct 7
includes taxes & fees
8.6/10 Excellent! (663 reviews)
The West End
Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

3720 W Clay St St. Charles MO
P7,424
P8,531 total
Oct 25 - Oct 26
includes taxes & fees
Hampton Inn St. Charles St. Peters
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

227 South Central Ave St. Louis MO
P8,031
P9,375 total
Oct 11 - Oct 12
includes taxes & fees
AC Hotel St. Louis Clayton

Explore a world of travel with Expedia