Top 10 Hotels Near Mississippi River in for 2026

A bridge spanning a body of water with a city skyline in the background during sunset.

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Our top choices for Mississippi River hotels

A Sleep Inn & Suites building with a covered entrance, stone facade, and a flag.

An indoor swimming pool with a lifeguard chair, poolside chairs, and a table with chairs.

A lobby with a reception desk, a seating area with sofas and armchairs, a large potted plant, and a door leading outside.

A hotel room with a bed, a desk, a chair, a sofa, and a TV mounted on the wall.

1. Sleep Inn & Suites Hannibal West

30.3 km from Mississippi River

Patricia

P7,253

P8,439 total

includes taxes & fees

Oct 11 - Oct 12

A gazebo with a table and benches, surrounded by trees and a body of water.

A hotel room with a desk, a television, a chair, a small refrigerator, a lamp, and a plant.

A two-story building with a flat roof and a covered entrance. There are two cars parked in front, and a truck is visible on the left.

A hotel room with a bed, two sofas, a small table, a desk with a chair, a TV, and a potted plant.

2. River's Edge Motel

13.6 km from Mississippi River

Kim

P5,185

P5,888 total

includes taxes & fees

Sep 29 - Sep 30

A restaurant with a bar area, wooden flooring, checkered tablecloths, and a brick wall.

A row of multi-story buildings with a variety of storefronts, including a coffee shop and a restaurant.

A staircase with wooden steps and a wooden handrail, leading up a brick wall.

A bedroom with a brick wall, a wooden bed, two bedside tables with lamps, and a ceiling fan.

3. The Eagles Nest Inn

14.2 km from Mississippi River

Gary

P7,028

P7,980 total

includes taxes & fees

Sep 29 - Sep 30

A room with a beige leather sofa, a wooden coffee table, a floor lamp, and a patterned carpet.

A wooden table with a bottle of champagne, two glasses, and scattered rose petals.

A hotel room with a bed, two bedside lamps, a headboard, and a patterned carpet.

A compact kitchen with a refrigerator, microwave, and sink.

4. Riverside Inn Hannibal

25.1 km from Mississippi River

Jack

P9,475

P13,091 total

includes taxes & fees

Sep 29 - Sep 30

A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

A multi-level indoor pool area with a clear pool, multiple balconies, and a covered seating area.

A hotel kitchen with a buffet setup, including a coffee station and various food items.

A multi-level indoor pool area with a visible water slide, a towel rack, and a notice board.

5. Best Western On The River

25.3 km from Mississippi River

Raymond

P6,872

P7,926 total

includes taxes & fees

Sep 30 - Oct 1

A hotel room with a large bed, a desk with a computer, a television, and a bathtub.

A hotel room with a sofa, armchair, small table, TV, dresser, and a bathtub.

A bar area with a long counter, multiple bottles, glasses, and a few chairs.

A hotel room with a bathtub, two yellow armchairs, a desk with a chair, a small table, and a lamp.

6. Oak Hill Inn & Suites

71.8 km from Mississippi River

Marie

P6,325

P7,209 total

includes taxes & fees

Oct 4 - Oct 5

An indoor swimming pool with a tiled floor, a rock wall, and a palm tree.

A hotel room with a bed, desk, chair, and a bathroom with a bathtub.

A spacious dining area with wooden flooring and tables, surrounded by glass walls and wooden paneling.

A lobby with leather sofas, a fireplace, a flat-screen TV, and a reception desk.

7. Quality Inn & Suites Hannibal West

30 km from Mississippi River

Gayle

P4,976

P5,790 total

includes taxes & fees

Oct 11 - Oct 12

A modern lobby with orange seating, a flat-screen TV, and a stone accent wall.

A hotel pool area with a hot tub, lounge chairs, and a 'No Diving Allowed' sign.

A gym with treadmills, stationary bikes, and a weight machine.

A hotel room with two beds, a headboard, bedside lamps, a clock, and a window with curtains.

8. Drury Plaza Hotel St. Louis St. Charles

104 km from Mississippi River

Robert

P8,496

P9,849 total

includes taxes & fees

Oct 12 - Oct 13

A modern kitchen with wooden cabinets, a granite countertop, a coffee machine, a microwave, a toaster, and a refrigerator.

A lobby with a reception desk, seating area, and a staircase.

A compact living space with a kitchenette, a sofa, a patterned armchair, and a television.

A compact living space with a dining table, two chairs, a sofa, a desk, and a kitchenette.

9. Heritage Hotel Quincy

47.8 km from Mississippi River

Dustine

P4,866

P5,546 total

includes taxes & fees

Oct 4 - Oct 5

A spacious lobby with a high ceiling, a dining area, and a seating area with sofas and a coffee table.

A spacious lobby with a blue sofa, round coffee table, and blue chairs. There is a reception desk and a seating area with a high ceiling and large windows.

A hotel room with a bed, a dresser, a nightstand with a lamp, a framed map on the wall, and a carpeted floor.

An outdoor patio area with a table and chairs, a glass door entrance, and a visible interior with a dining area.

10. Drury Inn & Suites St. Louis St. Peters

95.3 km from Mississippi River

Tiffany

P6,872

P7,899 total

includes taxes & fees

Oct 4 - Oct 5

A Holiday Inn Express & Suites building with a modern design, featuring a covered entrance and a landscaped area with trees.

A modern hotel corridor with a wooden reception desk, a staircase, and a snack bar with various packaged foods.

A modern breakfast area with a counter displaying various food items and a sign reading "EXPRESS START BREAKFAST".

A modern indoor space with a long white table, blue and orange chairs, a sofa with patterned cushions, and a coffee station.

11. Holiday Inn Express and Suites Alton St Louis Area by IHG

110.6 km from Mississippi River

Chris

P7,372

P8,403 total

includes taxes & fees

Oct 18 - Oct 19

A brick building with a sign reading "Country Inn & Suites."

An indoor swimming pool with a tiled floor, a central window, and multiple chairs around the pool.

A spacious living room with a large window, a wooden bookshelf, a green sofa, and a coffee table.

A modern kitchen with blue cabinetry, a central island with stools, pendant lighting, and a variety of kitchen appliances and utensils.

12. Country Inn & Suites by Radisson, St. Charles Historic District

103.7 km from Mississippi River

Roseanna

P8,895

P10,223 total

includes taxes & fees

Oct 12 - Oct 13

A staircase on a grassy hill with a sunset in the background.

A wooden deck with outdoor furniture, a small table, and a view of a red building and trees.

A kitchen with white cabinetry, a central island, stainless steel appliances, and decorative items on shelves.

A two-story building with a porch, a sign reading 'Green Tree Inn,' and an American flag.

13. The Green Tree Inn

95 km from Mississippi River

Natalie

P15,346

P17,031 total

includes taxes & fees

Oct 12 - Oct 13

A hotel room with a bed, a desk with a computer, a TV, and a bathroom with a shower.

A hotel entrance with a sign reading "Quality Inn & Suites by Choice Hotels".

A modern kitchen with dark cabinets, a central island with bar stools, and pendant lighting.

A reception area with a reception desk, seating area with chairs, a patterned rug, and a large window with a view of the outside.

14. Quality Inn & Suites Quincy - Downtown

47.8 km from Mississippi River

Cathy

P7,435

P8,474 total

includes taxes & fees

Oct 29 - Oct 30

A hotel room with a bed, a sofa, a coffee table, and wall art.

An indoor swimming pool with a clear view of the outside, a metal ladder, and a ceiling with recessed lighting.

A restaurant with wooden tables and chairs, a blue wall with white floral patterns, and a counter with a coffee machine.

A Sleep Inn & Suites hotel with a modern brick facade, a covered entrance, and a parking lot.

15. Sleep Inn & Suites O'Fallon MO - Technology Drive

100.2 km from Mississippi River

Tim

P4,948

P5,836 total

includes taxes & fees

Sep 29 - Sep 30

A hotel room with a bed, a desk with a TV, a chair, a sofa, and a window with curtains.

16. Hampton Inn & Suites St. Louis/Alton

110.3 km from Mississippi River

Kathy

P8,145

P9,284 total

includes taxes & fees

Oct 18 - Oct 19

A hot tub with a rocky backdrop and a mural.

A cozy log cabin interior with a fireplace, wooden furniture, and a television mounted on the wall.

An indoor swimming pool with a 'No Diving' sign, lounge chairs, and a mural on the wall.

A restaurant with wooden walls, a bar area, and multiple seating arrangements.

17. Stoney Creek Inn Quincy

46.5 km from Mississippi River

Kent

P7,535

P8,588 total

includes taxes & fees

Oct 4 - Oct 5

A wooden staircase with a handrail, a small table with a lamp, and a chair in a room with a door and windows.

A cozy living room with a fireplace, a red armchair, a globe, and various framed pictures on the mantel.

A dining area with a table set for four, surrounded by wooden chairs. A chandelier hangs above the table, and a lamp provides additional lighting.

A fireplace with decorative elements, framed pictures, and a vase of red flowers.

18. Garden House Bed and Breakfast

25.2 km from Mississippi River

Edward

P5,788

P6,677 total

includes taxes & fees

Sep 29 - Sep 30

A hotel room with a large bed, two bedside lamps, a modern bathroom, and a vibrant abstract painting on the wall.

A compact kitchen with white cabinets, a microwave, a coffee maker, and a sink.

A spacious bathroom with a large bathtub, a walk-in shower, and a vanity with a mirror.

A modern living room with a grey sofa, a white armchair, a coffee table, and a patterned rug. There is a kitchen in the background with white cabinets and a black door.

19. Lighthouse Inn & Suites

25.8 km from Mississippi River

Kari

P10,549

P12,169 total

includes taxes & fees

Oct 4 - Oct 5

An outdoor patio area with wicker furniture, a stone fire pit, and a building in the background.

A Courtyard by Marriott hotel with a modern design, multiple floors, and a flat roof.

A modern lobby with a sofa, armchairs, a coffee table, and a bookshelf.

20. Courtyard by Marriott St. Louis St. Peters

97.2 km from Mississippi River

Krischel

P7,534

P9,049 total

includes taxes & fees

Oct 5 - Oct 6

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Compare popular hotels close to Mississippi River

Property	Property class	Guest rating
Sleep Inn & Suites Hannibal West	9.6 Exceptional 1,000 reviews	View
River's Edge Motel	9.0 Wonderful 390 reviews	View
The Eagles Nest Inn	9.4 Exceptional 26 reviews	View
Riverside Inn Hannibal	9.6 Exceptional 199 reviews	View
Best Western On The River	8.6 Excellent 1,007 reviews	View

Top Mississippi River Hotel Reviews

Drury Plaza Hotel St. Louis at the Arch

10/10 Excellent

"Can’t say enough how special this hotel, staff and site was for us. I’m a Drury Inn customer and found this site beyond my expectations. Room spotless, and food options great!"

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

10/10 Excellent

"Relaxing night unwinding on rooftop bar."

21C Museum Hotel St Louis

10/10 Excellent

"Such a cool and trendy boutique hotel with all the amenities. Beautiful building. Paid parking around d the corner. 20 minutes walk to the Gateway Arch. So nice to get back to the hotel in the evening, have a few drinks at the bar and finish the evening with a visit to the pool area with hot tub, sauna, and steam room as well as the lap pool. Staff were incredible, so friendly and knowledgeable. Kristos and all the other bartenders were super friendly and made us some great cocktails. Would definitely recommend to friends and family and would stay again if we were back in the area."

Pear Tree Inn St. Louis Near Union Station

8/10 Good

"I wish that the Pear Inn Hotel provided shuttle service to their guests."

Clayton Plaza Hotel & Extended Stay

10/10 Excellent

"We loved our stay. Everything was clean and the bed was the most comfortable hotel bed I’ve slept on. We had a blast. The breakfast was delicious."

Live by Loews - St.Louis

10/10 Excellent

"Wonderful stay. Comfy bed. One of cleanest rooms I’ve ever stayed in. It is convenient to Busch Stadium, but just a heads up that if you stay there, any of the events may be cause for a bit of noise - but with the television on, it just sounded like any metropolitan area. Would not hesitate to stay again."

Renaissance St. Louis Airport Hotel

10/10 Excellent

"Staff was great! Would come back to stay."

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

8/10 Good

"Staff was excellent, rooms are clean, bed and bedding excellent and comfortable, hallways showing a little wear, breakfast choices could offer more variety. Overall the stay was nice for our concert trip"

Hampton Inn St. Charles St. Peters

10/10 Excellent

"Friendly and helpful staff. Very good breakfast and coffee. Clean rooms."

Other attractions near Mississippi River

Mark Twain Cave

8.8/10 (89 reviews)

You can find out about the history of Hannibal with a visit to Mark Twain Cave. While in this trendy area, you can savor the top-notch restaurants.

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Sawyer's Creek Fun Park

7.8/10 (16 reviews)

Explore the great outdoors at Sawyer's Creek Fun Park, a lovely green space in Hannibal. While in this walkable area, you can savor the top-notch restaurants.

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Lovers Leap

8.8/10 (171 reviews)

Find out about the history of Hannibal with a stop at Lovers Leap. While in this walkable area, you can savor the top-notch restaurants.

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Sodalis Nature Preserve

Explore the great outdoors at Sodalis Nature Preserve, a lovely green space in Hannibal. While in this family-friendly area, you can savor the top-notch restaurants.

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Bluff City Theater

7.6/10 (5 reviews)

Enjoy a show at Bluff City Theater, a theater with a story to tell in Hannibal. While in this family-friendly area, you can savor the top-notch restaurants.

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Planters Barn Theater

8.8/10 (22 reviews)

Enjoy a show at Planters Barn Theater, a storied theater in Hannibal. While in this walkable area, you can savor the top-notch restaurants.

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Mark Twain Boyhood Home and Museum

9.0/10 (278 reviews)

Find out about the history of Hannibal when you take a trip to Mark Twain Boyhood Home and Museum. While in this family-friendly area, you can savor the top-notch restaurants.

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Jim's Journey: The Huck Finn Freedom Center

8.4/10 (33 reviews)

You can browse the exhibits at Jim's Journey: The Huck Finn Freedom Center, a museum with a story of its own, during your travels to Hannibal. While in this family-friendly area, you can savor the top-notch restaurants.

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Frequently asked questions

What's the area like around Mississippi River?

Mississippi River is located in an area that travelers like for its baseball games. When you want to settle in and find a place to stay, check out some of the hotels and other accommodations that Expedia offers in the area.

What's the best place to stay close to Mississippi River?

Hollywood Casino & Hotel St. Louis is one of the top choices for your stay based on our traveler data, and this hotel offers a casino and 7 restaurants. You'll find it 65.7 mi (105.7 km) from Mississippi River. Other good options around the area include Hyatt Regency St. Louis at The Arch and Clayton Plaza Hotel & Extended Stay.

If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?

Yes, you'll find most hotel reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and be given a refund within a 24-hour period of booking. Add your dates and click on "Search", then use the filter option "fully refundable" to get top deals close to Mississippi River.

Hotels near Mississippi River

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Our top choices for Mississippi River hotels

1. Sleep Inn & Suites Hannibal West

2. River's Edge Motel

3. The Eagles Nest Inn

4. Riverside Inn Hannibal

5. Best Western On The River

6. Oak Hill Inn & Suites

7. Quality Inn & Suites Hannibal West

8. Drury Plaza Hotel St. Louis St. Charles

9. Heritage Hotel Quincy

10. Drury Inn & Suites St. Louis St. Peters

11. Holiday Inn Express and Suites Alton St Louis Area by IHG

12. Country Inn & Suites by Radisson, St. Charles Historic District

13. The Green Tree Inn

14. Quality Inn & Suites Quincy - Downtown

15. Sleep Inn & Suites O'Fallon MO - Technology Drive

16. Hampton Inn & Suites St. Louis/Alton

17. Stoney Creek Inn Quincy

18. Garden House Bed and Breakfast

19. Lighthouse Inn & Suites

20. Courtyard by Marriott St. Louis St. Peters

Compare popular hotels close to Mississippi River

Top Mississippi River Hotel Reviews

Drury Plaza Hotel St. Louis at the Arch

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

21C Museum Hotel St Louis

Pear Tree Inn St. Louis Near Union Station

Clayton Plaza Hotel & Extended Stay

Live by Loews - St.Louis

Renaissance St. Louis Airport Hotel

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Hampton Inn St. Charles St. Peters

Other attractions near Mississippi River

Mark Twain Cave

Sawyer's Creek Fun Park

Lovers Leap

Sodalis Nature Preserve

Bluff City Theater

Planters Barn Theater

Mark Twain Boyhood Home and Museum

Jim's Journey: The Huck Finn Freedom Center

Frequently asked questions