Hotels near Mississippi River

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 30 - Dec 31
Tomorrow
Dec 31 - Jan 1
This weekend
Jan 2 - Jan 4
Next weekend
Jan 9 - Jan 11

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Mississippi River hotels

Balcony
River's Edge Motel

River's Edge Motel

River's Edge Motel
2.0 star property
13.6 km from Mississippi River
9.0 out of 10, Wonderful, (358)
"Excellent stay !!! Quite "
United States
Bradley
The price is P4,706
P5,343 total
includes taxes & fees
Jan 1 - Jan 2, 2026
River's Edge Motel
Interior
The Eagles Nest Inn

The Eagles Nest Inn

The Eagles Nest Inn
3.0 star property
14.2 km from Mississippi River
9.4 out of 10, Exceptional, (19)
"It was very clean and very nice place to stay, has a very home and cozy feeling walking into the room."
United States
Bryan
The price is P5,625
P6,386 total
includes taxes & fees
Jan 5 - Jan 6, 2026
The Eagles Nest Inn
Desk, laptop workspace, iron/ironing board, free WiFi
Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal
2.5 star property
26.3 km from Mississippi River
6.4 out of 10, (737)
" There actually was a pool & there actually was a hot breakfast. It didn't just say there was & not have what was listed. One of the best we've been to as of late. Would stay again if in the area. "
United States
Thomas
The price is P3,441
P3,979 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Baymont by Wyndham Hannibal
Desk, iron/ironing board, free WiFi, bed sheets
Super 8 by Wyndham O'Fallon MO/St. Louis Area

Super 8 by Wyndham O'Fallon MO/St. Louis Area

Super 8 by Wyndham O'Fallon MO/St. Louis Area
2.0 star property
90.7 km from Mississippi River
6.8 out of 10, (999)
"Very run down and trash around the property, but the room was clean and comfortable for our one night stop. Convenience of the location"
United States
Natalie
The price is P3,900
P4,600 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Super 8 by Wyndham O'Fallon MO/St. Louis Area
Lobby
Economy Inn Wentzville

Economy Inn Wentzville

Economy Inn Wentzville
2.0 star property
86.8 km from Mississippi River
6.4 out of 10, (511)
"The room was dirty so dirty we left didn't spend the night there, and the smell in the building weed or something else not sure which, it was ridiculous so we went to Hannibal and stayed at the Days inn "
United States
paul
The price is P3,529
P4,004 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Economy Inn Wentzville
Lobby
Relax Inn Saint Charles

Relax Inn Saint Charles

Relax Inn Saint Charles
2.0 star property
98 km from Mississippi River
6.6 out of 10, (1004)
"Great place to stay "
United States
Askar
The price is P3,706
P4,259 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Relax Inn Saint Charles
55-inch TV with cable channels, Netflix, Hulu
Riverside Inn Hannibal

Riverside Inn Hannibal

Riverside Inn Hannibal
2.5 star property
25.1 km from Mississippi River
9.4 out of 10, Exceptional, (165)
"Great place to stay!"
United States
Sandy
The price is P9,472
P12,905 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Riverside Inn Hannibal
Indoor pool, seasonal outdoor pool, pool umbrellas, sun loungers
Best Western On The River

Best Western On The River

Best Western On The River
2.5 star property
25.3 km from Mississippi River
8.6 out of 10, Excellent, (1001)
"Great stay! Clean and cozy!!"
United States
Courtney
The price is P5,999
P6,890 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Best Western On The River
Lobby
Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles
2.0 star property
93.8 km from Mississippi River
6.2 out of 10, (1001)
"Room was excellent and clean"
United States
catherine
The price is P3,800
P4,368 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Days Inn by Wyndham St Peters/St Charles
Exterior
Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
2.5 star property
30.3 km from Mississippi River
9.6 out of 10, Exceptional, (1000)
"Great location, breakfast was normal nothing special, hotel was clean and quiet. Yes I would stay there again"
United States
Bernard
The price is P5,771
P6,685 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Sleep Inn & Suites Hannibal West
Premium bedding, desk, laptop workspace, iron/ironing board
La Quinta Inn by Wyndham St. Louis Hazelwood - Airport North

La Quinta Inn by Wyndham St. Louis Hazelwood - Airport North

La Quinta Inn by Wyndham St. Louis Hazelwood - Airport North
3.0 star property
109.6 km from Mississippi River
6.6 out of 10, (1002)
"Staff was great "
United States
Courtney
The price is P3,600
P4,401 total
includes taxes & fees
Jan 1 - Jan 2, 2026
La Quinta Inn by Wyndham St. Louis Hazelwood - Airport North
Property amenity
Extended Stay America Select Suites St Louis Earth City

Extended Stay America Select Suites St Louis Earth City

Extended Stay America Select Suites St Louis Earth City
2.5 star property
107.1 km from Mississippi River
6.6 out of 10, (883)
"Nothing bad to say about this Hotel. Great, clean rooms and awesome staff."
United States
Charles
The price is P4,711
P5,652 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Extended Stay America Select Suites St Louis Earth City
Lobby
Baymont by Wyndham Keokuk

Baymont by Wyndham Keokuk

Baymont by Wyndham Keokuk
2.5 star property
96.1 km from Mississippi River
6.2 out of 10, (492)
"I had to pay for my family to swim in the pool. The poll area was hazardous because there was drywall pealing off from the ceiling and around the pool. "
United States
Clarence and Kari
The price is P3,496
P3,915 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Baymont by Wyndham Keokuk
Exterior
LAKEVIEWINN

LAKEVIEWINN

LAKEVIEWINN
2.5 star property
89.4 km from Mississippi River
5.4 out of 10, (31)
"I enjoyed it! And the owners were so sweet and understanding. I would absolutely stay there again!"
United States
Evelyn
The price is P3,971
P4,485 total
includes taxes & fees
Jan 11 - Jan 12, 2026
LAKEVIEWINN
Interior entrance
Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Americas Best Value Inn & Suites St. Louis, St. Charles Inn
2.5 star property
103.4 km from Mississippi River
5.8 out of 10, (1004)
"Nice staff, respectful."
United States
LaurenRenee
The price is P4,117
P4,773 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Americas Best Value Inn & Suites St. Louis, St. Charles Inn
Down comforters, blackout drapes, iron/ironing board, free WiFi
Lighthouse Inn & Suites

Lighthouse Inn & Suites

Lighthouse Inn & Suites
4.0 star property
25.8 km from Mississippi River
8.8 out of 10, Excellent, (24)
"Very nice room, close enough to walk to riverfront attractions. "
United States
Robert
The price is P9,933
P11,408 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Lighthouse Inn & Suites
Indoor pool, sun loungers
Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
2.5 star property
26.2 km from Mississippi River
7.6 out of 10, Good, (662)
"Below average facility. Needs some upgrades and could use a good cleaning. Staff was helpful."
United States
JACQUI
The price is P4,471
P5,311 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Comfort Inn & Suites - Hannibal
Front of property
Garden House Bed and Breakfast

Garden House Bed and Breakfast

Garden House Bed and Breakfast
2.0 star property
25.2 km from Mississippi River
8.6 out of 10, Excellent, (38)
"Overall stay was great and the host chris is great aswell nothing bad to say about any aspect of our stay!"
United States
Josh
The price is P6,300
P7,236 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Garden House Bed and Breakfast
Lobby sitting area
Motel 6 Hannibal, MO

Motel 6 Hannibal, MO

Motel 6 Hannibal, MO
2.0 star property
26.1 km from Mississippi River
7.4 out of 10, Good, (1003)
"Very clean rooms and staff is very friendly "
United States
Sherrie
The price is P3,411
P3,918 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Motel 6 Hannibal, MO
Lobby
Sleep Inn Saint Charles North

Sleep Inn Saint Charles North

Sleep Inn Saint Charles North
2.5 star property
97.1 km from Mississippi River
5.8 out of 10, (519)
"They closed down breakfast earlier than 9. "
United States
Alicea
The price is P4,087
P4,697 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Sleep Inn Saint Charles North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Mississippi River Hotel Reviews

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

10/10 Excellent
"Room was clean and comfy."
Christina 3-night trip
Posted 13 hours ago
Drury Plaza Hotel St. Louis at the Arch

Hotels near other Mississippi River attractions

Mark Twain Cave

4.4/5 (128 reviews)
Explore the great outdoors at Mark Twain Cave, a lovely green space in Hannibal. While in this trendy area, you can savor the top-notch restaurants.
See properties

Mark Twain Cave and Cameron Cave

4.5/5 (51 reviews)
You can find out about the history of Hannibal with a visit to Mark Twain Cave and Cameron Cave. While in this trendy area, you can savor the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Mississippi River?
Mississippi River is located in an area that travelers like for its baseball games. When you want to settle in and find a place to stay, check out some of the hotels and other accommodations that Expedia offers in the area.
What's the best place to stay close to Mississippi River?
Hyatt Regency St. Louis at The Arch is one of the top choices for your stay based on our traveler data, and this hotel offers 3 restaurants and 2 bars. You'll find it 82.1 mi (132.1 km) from Mississippi River. Other good options around the area include Hampton Inn St. Louis-Downtown (At the Gateway Arch) and Magnolia Hotel St. Louis, a Tribute Portfolio Hotel.
If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?
Yes, you'll find most hotel reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and be given a refund within a 24-hour period of booking. Add your dates and click on "Search", then use the filter option "fully refundable" to get top deals close to Mississippi River.