Mesopotamia Hotels

To Spiti tis Sofias is one of the top choices for your stay based on our traveler data. This guesthouse offers free parking and free WiFi. Two other choices for your visit to the area are Limneon Resort & Spa and Hotel Anastassiou. See all available top hotels, or vacation rentals in Mesopotamia.

Yes! You'll find that most room reservations are refundable provided that you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you might still have the option to cancel and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Mesopotamia.

For more details about picking new dates or cancelling your trip to Mesopotamia, click here.

Hyatt Regency Thessaloniki is a popular 5-star hotel featuring 2 outdoor pools and a full-service spa. It's located a short 1.1 mi (1.8 km) from Macedonia Airport. Other options near the airport are Athina Airport Hotel and Hotel Nikopolis.

Travelers to Mesopotamia will find plenty to explore and enjoy. There are 41 hotels and other accommodations in the surrounding area. Find out more about Mesopotamia.

Places to visit in the wider area include Kastoria Lake, Dragon's Lair, and Holy Monastery of Panagias Mauriotissas. You'll also find Folklore Museum of Kastoria and Neolithic Lakeside Settlement in the area. Check out what more to see and do in Expedia's Mesopotamia guide.

The hottest months are usually August and July with an average temp of 69°F, while the coldest months are January and February with an average of 37°F. Average annual precipitation for Mesopotamia is 28 inches.