A historic building with a dome and columns, surrounded by trees and benches.

Hotels with Spa in Mesagne, Puglia

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Mesagne Hotels with Spa

Tonight
Oct 11 - Oct 12
Tomorrow
Oct 12 - Oct 13
Next weekend
Oct 16 - Oct 18
In two weeks
Oct 23 - Oct 25

Our top choices for Mesagne hotels with a spa

Indoor spa tub
Hallway
Interior
Front of property - evening/night

1. Tenuta Moreno

Tenuta Moreno
Mesagne
  • Relax and rejuvenate at this Beaux Arts hotel with a full-service spa offering aromatherapy and Ayurvedic treatments.
P7,784
P8,562 total
includes taxes & fees
Oct 17 - Oct 18
Tenuta Moreno
A modern indoor pool area with a glass wall, white lounge chairs, and a visible sauna area.
An aerial view of a coastal area with clear turquoise waters, sandy beaches, and lush greenery.
An indoor dining area with tables and chairs, large windows, and potted plants.
A restaurant with white tables and chairs, large windows, and hanging light fixtures.

2. Masseria Elysium

Masseria Elysium
Mesagne
  • Rejuvenate at this Mediterranean farm stay offering indulgent spa services, a hot tub, and a sauna amid serene garden landscapes.
P6,929
P7,622 total
includes taxes & fees
Oct 13 - Oct 14
Masseria Elysium
A modern interior with a glass-enclosed shower, a seating area with candles, and a wooden floor.
A poolside area with a person holding a drink, surrounded by large tropical leaves and a stone wall.
A bedroom with a large bed, white bedding, and a canopy.
A beach scene with a thatched roof structure, white lounge chairs, and a red boat labeled "SAINT FRANCOIS" in the water.

3. Masseria Messapia Wine Resort & SPA

Masseria Messapia Wine Resort & SPA
Mesagne
  • Luxurious Turkish bath and deep-tissue massages await at this winery resort with private beach access.
P14,968
P16,465 total
includes taxes & fees
Oct 17 - Oct 18
Masseria Messapia Wine Resort & SPA
A person lying on a massage table with a view of a pool and outdoor seating.
A stone building with arched windows and a covered outdoor seating area.
A stone building with a sign reading "RISTORANTE" and a bench in front.
A stone pathway leading through a park with trees and ruins.

4. Tenute Al Bano

Tenute Al Bano
Cellino San Marco
  • Enjoy rejuvenating treatments at this rural retreat with couples spa rooms, an outdoor pool, and an attached winery for a complete escape.
P8,307
P9,279 total
includes taxes & fees
Oct 22 - Oct 23
Tenute Al Bano
A modern interior with a stone wall and a curved seating area.
A dining table with a pizza, wine bottle, glasses, and fresh ingredients.
A modern indoor pool area with a large, textured wall and a central pillar.
A restaurant with round tables set for dining, featuring white tablecloths, neatly folded napkins, and wine glasses.

5. Hotel Monte Sarago

Hotel Monte Sarago
Ostuni
  • Indulge in rejuvenating treatments at this upscale hotel with 3 couples' spa rooms, Turkish hammam, and rooftop terrace.
P5,640
P6,626 total
includes taxes & fees
Nov 2 - Nov 3
Hotel Monte Sarago
A spa area with a pool, a massage chair, and a sauna.
A cozy room with a fireplace, two lounge chairs, and a patterned rug.
A spacious lounge with a high stone ceiling, a bar area in the background, and a red carpeted floor.
A stone vaulted room with a wooden table and chairs, a wine rack, and a globe.

6. Masseria Palombara Relais & SPA - Adults only

Masseria Palombara Relais & SPA - Adults only
Oria
  • Country estate offers sauna, seasonal pool, restaurant, yoga sessions, and spa treatments for serene escapes.
P14,419
P15,861 total
includes taxes & fees
Oct 12 - Oct 13
Masseria Palombara Relais & SPA - Adults only
A bathroom with a wooden ladder, a sink, a stone wall, and baskets on the counter.
A hotel room with a bed, a desk with a lamp, a chair, and a view of the city through a window.
A spa area with a hot tub, lounge chairs, and a view of a white building.
A coastal cityscape at dusk with illuminated lanterns and historic buildings.

7. Ostuni Palace Hotel Ristorante & SPA

Ostuni Palace Hotel Ristorante & SPA
Ostuni
  • Luxurious Mediterranean escape with indulgent spa treatments, hot tub, and tranquil garden setting for ultimate relaxation.
P11,426
P12,991 total
includes taxes & fees
Oct 13 - Oct 14
Ostuni Palace Hotel Ristorante & SPA
A sauna with wooden walls and a bench.
A kitchen with white walls, a stone accent wall, a wooden table with a bowl of fruit, a bottle, and a cup. There are two white chairs and a hanging light fixture.
A compact room with a white sofa, a small table with stools, a glass door leading to another room, and pendant lighting.
A modern bathroom with a glass-enclosed shower, a bathtub with green water, and a large mirror.

8. FILIA SOLIS - Old Town SUITEs & SPA

FILIA SOLIS - Old Town SUITEs & SPA
Brindisi Historic Center
  • Relax in the heart of Old Town Brindisi with private hot tubs and luxurious massages at this spa-focused aparthotel retreat.
P7,511
P8,685 total
includes taxes & fees
Nov 1 - Nov 2
FILIA SOLIS - Old Town SUITEs & SPA
A modern bathroom with a large bathtub, a wooden vanity, and a seating area with a bench and cushions.
A hot tub with water bubbling, a wooden cabinet, a potted plant, and a doorway leading to another room.
A modern living room with a curved sofa, a blue armchair, and a wooden cabinet.
A modern bedroom with a bed, bedside tables, a nightstand, a desk with a chair, a potted plant, and a window with curtains.

9. Centrale Suites

Centrale Suites
Brindisi Historic Center
P4,491
P5,291 total
includes taxes & fees
Nov 1 - Nov 2
Centrale Suites
A reception area with a wooden counter, a round mirror, and a chandelier.
A building with a balcony, stairs, and a signboard.
A modern indoor pool with a water feature, arched ceilings, and a reception area visible through an archway.
A modern bathroom with a bathtub, a sink, and a mirror. There are shelves with toiletries and a towel rack.

10. Dimora Nettare

Dimora Nettare
Brindisi Historic Center
  • Soothe away stress at this rejuvenating affittacamere featuring Swedish, Thai, and hot stone massages near Port of Brindisi.
P6,334
P7,320 total
includes taxes & fees
Oct 14 - Oct 15
Dimora Nettare
View all properties

Choose what matters most at spa hotels in Mesagne

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Mesagne Hotel Reviews

Hotel Orientale

Hotel Orientale

10/10 Excellent
"Fabulous! Had a lovely stay in a great location. Staff were brilliant"
Steven 7-night trip
Posted 3 days ago
Hotel Orientale
Le Dune Suite Hotel

Le Dune Suite Hotel

10/10 Excellent
"A bit out of the way and surrounding area isnt the nicest but one of the nicest beaches in Italy so far. Hotel is nice, well maintained, great staff. Excellent breakfast, easy parking and the sunsets from the beach bar are outstanding!"
Penny 1-night trip
Posted 7 days ago
Le Dune Suite Hotel
Ostuni Palace Hotel Ristorante & SPA

Ostuni Palace Hotel Ristorante & SPA

10/10 Excellent
"We really enjoyed our stay at Ostuni Palace Hotel Ristorante & Spa. The location was fantastic, with beautiful views of Ostuni right outside the hotel and only about a 10-minute walk to the historic centre. Our room was very clean and spacious, and the bathroom was surprisingly large, which was a nice bonus. The hotel itself is beautiful and well maintained, and breakfast was very good with a great selection. Another big plus was the free parking, which made having a car in Ostuni so much easier. Breakfast and parking being included made the stay even better value. We didn’t get a chance to try the spa during our stay, but it’s a nice option to have on-site. Overall, a beautiful hotel in a great location for exploring Ostuni."
Teresa 2-night trip
Posted 2 weeks ago
Ostuni Palace Hotel Ristorante & SPA
Masseria Salinola

Masseria Salinola

10/10 Excellent
"Masseria Salinola was everything we hoped a stay at a family-run masseria in Puglia would be: charming, intimate and incredibly welcoming. With only 12 rooms, there was a wonderful sense of connection here that we didn’t experience at larger hotels. We found ourselves chatting with other guests throughout our stay, which made it feel less like staying at a hotel and more like being welcomed into a small community. If you stay here, you absolutely must have dinner at the masseria at least once. Dinner is served by candlelight under the trees on the patio, with fire pits glowing nearby, and the entire setting is simply stunning. It was one of those experiences where the atmosphere becomes as memorable as the meal itself. The family-run nature of Masseria Salinola gives it a warmth and personality that is difficult to manufacture. It was charming, beautiful and genuinely special, and exactly the kind of experience we were hoping to find in Puglia. We would absolutely recommend it."
Kimberly 3-night trip
Posted 1 month ago
Masseria Salinola
Tenuta Moreno

Tenuta Moreno

10/10 Excellent
"My Sons Wedding. Perfect in all ways. Super helpful staff, lovely, clean rooms, Outstanding food, Young man on the bar was brilliant, well kept grounds and pool area, Thank you! A beautiful experience for all our family."
John Richard 3-night trip
Posted 1 month ago
Tenuta Moreno

Frequently asked questions

Looking to vacation at a spa hotel in Mesagne?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the historical sites and restaurants in Mesagne—your day trip starts here. Take in the culture at the monuments and museums during your stay. Spa hotels are a great way to break out of your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Mesagne?
Tenuta Moreno is a top spa hotel featuring a rooftop terrace, a fitness center, tennis courts, and a bar. Enjoy a facial, body scrub, or thalassotherapy at the onsite spa. Another popular spa hotel in Mesagne is Masseria Messapia Wine Resort & SPA.
How many spa hotels are there in Mesagne?
Among Expedia's 84 accommodation options in Mesagne, there are 3 spa hotels.
What's there to see and do in Mesagne?
Enjoy all that Mesagne has to offer and visit Mesagne Castle, Teatro Comunale di Mesagne, and Piazza Orsini del Balzo. If you have some spare time during your trip, you might want to check out Court of Brindisi and Carrisiland Resort.
What is a Mesagne spa hotel?
Spa hotels in Mesagne provide lodging and have a full on-site spa which offers services including facials as well as body treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.

Explore a world of travel with Expedia