La Mesa Vacation Rentals

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Apr 17 - Apr 19
In two months
May 29 - May 31
In three months
Jun 26 - Jun 28
In four months
Jul 24 - Jul 26

Our top choices for La Mesa vacation rentals

Rooftop terrace

Sentral Gaslamp Quarter

Sentral Gaslamp Quarter
4.0 star property
Downtown San Diego
9.4 out of 10, Exceptional, (808 reviews)
"Great location"
United States
Ethan
The price is P7,597
P10,569 total
includes taxes & fees
Apr 2 - Apr 3
Sentral Gaslamp Quarter
Exterior

Marriott Vacation Club®, San Diego

Marriott Vacation Club®, San Diego
3.5 star property
Downtown San Diego
9.4 out of 10, Exceptional, (1,049 reviews)
"The hotel was very clean and had very friendly staff. Location was amazing."
United States
Brenda
The price is P11,298
P13,100 total
includes taxes & fees
Apr 28 - Apr 29
Marriott Vacation Club®, San Diego
3 bedrooms, desk, Internet

Stunning View Mission Bay Luxury Home Private Pool

Stunning View Mission Bay Luxury Home Private Pool
2.0 star property
Bay Park
The price is P21,282
P54,537 total
includes taxes & fees
Apr 12 - Apr 13
Stunning View Mission Bay Luxury Home Private Pool
Beach nearby

Coronado Beach Resort

Coronado Beach Resort
3.0 star property
Historic Downtown Coronado
9.0 out of 10, Wonderful, (780 reviews)
"Excellent location, clean and cozy"
United States
Oksana
The price is P13,733
P15,107 total
includes taxes & fees
Apr 26 - Apr 27
Coronado Beach Resort
Interior

Large Group Wellness Retreat w Spa & Gym

Large Group Wellness Retreat w Spa & Gym
3.0 star property
University City
Large Group Wellness Retreat w Spa & Gym
Interior

Walk to La Jolla Cove: Dtwn Cottage w/ Ocean View!

Walk to La Jolla Cove: Dtwn Cottage w/ Ocean View!
3.0 star property
Village of La Jolla
The price is P37,175
P62,438 total
includes taxes & fees
Apr 14 - Apr 15
Walk to La Jolla Cove: Dtwn Cottage w/ Ocean View!
Aerial view

Wave Crest Resort

Wave Crest Resort
3.0 star property
Del Mar
9.2 out of 10, Wonderful, (151 reviews)
"Clean and convenient location."
United States
Jeffrey
The price is P13,134
P16,900 total
includes taxes & fees
Apr 15 - Apr 16
Wave Crest Resort
Lobby sitting area

Uptown Inn by Vantaggio - Limited Service Apart-Hotel

Uptown Inn by Vantaggio - Limited Service Apart-Hotel
2.5 star property
Hillcrest
8.4 out of 10, Very Good, (326 reviews)
"It is a clean place to stay and budget friendly. Unfortunately the noise from the road can make it hard to sleep."
United States
Afia
The price is P7,096
P8,001 total
includes taxes & fees
Apr 12 - Apr 13
Uptown Inn by Vantaggio - Limited Service Apart-Hotel
Terrace/patio

City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (133 reviews)
"Clean nice place to stay at"
United States
Luis
The price is P8,608
P11,771 total
includes taxes & fees
Apr 6 - Apr 7
City24 Hotel Little Italy Mission Hills
Outdoor pool

Kasa Little Italy San Diego

Kasa Little Italy San Diego
4.5 star property
Downtown San Diego
9.6 out of 10, Exceptional, (399 reviews)
"Excellent location Clean Just as showed in pictures"
United States
Carina Jose
The price is P12,088
P19,103 total
includes taxes & fees
Apr 5 - Apr 6
Kasa Little Italy San Diego
Lobby

Little Italy Inn - Limited Service Apart Hotel

Little Italy Inn - Limited Service Apart Hotel
2.5 star property
Downtown San Diego
8.4 out of 10, Very Good, (117 reviews)
"Perfect stay!"
United States
Kaylee
The price is P6,535
P7,433 total
includes taxes & fees
Apr 2 - Apr 3
Little Italy Inn - Limited Service Apart Hotel
1 bedroom, desk, Internet

NEW Upscale Downtown San Diego Stay Queen Bed Pool Sauna

NEW Upscale Downtown San Diego Stay Queen Bed Pool Sauna
2.0 star property
Downtown San Diego
The price is P14,493
P28,454 total
includes taxes & fees
Apr 12 - Apr 13
NEW Upscale Downtown San Diego Stay Queen Bed Pool Sauna
Individually decorated, individually furnished, laptop workspace

Kasa Gaslamp Quarter San Diego

Kasa Gaslamp Quarter San Diego
3.5 star property
Downtown San Diego
7.8 out of 10, Good, (176 reviews)
"Clean room, air conditioning worked and security is great "
United States
Elizabeth
The price is P5,740
P6,541 total
includes taxes & fees
Apr 6 - Apr 7
Kasa Gaslamp Quarter San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top La Mesa Hotel Reviews

Paradise Point Resort & Spa

Paradise Point Resort & Spa

6/10 Okay
"The lodging accommodations need some love. There was peeling paint and damage at the bottom of the doors to our bathroom. The tub spigot looks like a cut off pipe. The grounds around our lodging were very sloppy looking...leaves and limbs laying everywhere. The pergolas outside on our patio all seemed slanted and falling apart. However, the pool and the rest of the grounds seemed to be in great shape. We went to the casual restaurant for breakfast and were seated right away. Unfortunately, we sat for 15 minutes without waitstaff coming to our table. We alerted the bus boy, who I saw speak with someone about it. We waited 5 more minutes after that and when no one showed up we left. Then we went over to the cafe and they were out of the first 4 items we tried to order. Seems like maybe the resort was not prepared for the spring break crowd. The staff who did help us were very nice.This looks like a place that was once a top-notch resort, but now has room for improvement."
Katherine 1-night trip
Posted 1 hour ago
Paradise Point Resort & Spa

Find out more about La Mesa

Search for holiday rentals in La Mesa on Expedia! You can easily find your home rentals, villas, holiday apartments in La Mesa using one of the methods below:

  • View our selection of featured holiday rentals in La Mesa
  • Use the map to find apartments and other holiday homes in the La Mesa neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in La Mesa while they last

Look no further and take a look at our great range of rental properties in La Mesa!

Frequently asked questions

Are there vacation rentals in La Mesa?

Yes, you can find vacation rentals in La Mesa near La Mesa Memorial Fine Arts Center, or you can choose a secluded option if you'd like a relaxing place to stay. Visitors like the top-notch restaurants and shops in La Mesa. Leave some time to check out the zoo and entertainment venues during your trip.

How many vacation rentals are there in La Mesa?

With 64 Expedia vacation rentals, you're sure to find just the right place for your La Mesa stay.

What can I see and do in La Mesa?

Explore the area and cultural attractions such as Computer Museum of America, or visit a family-friendly sight such as San Diego Zoo. While in the area, you can also visit popular places like Mission Bay and Petco Park.

What are vacation rentals like in La Mesa?

Vacation rentals are privately owned properties you can book for several days or more in La Mesa. Vacation rentals feature amenities such as WiFi and washers and dryers so you'll have everything you need. If you're concerned about a clean environment, vacation rentals can provide a sense of safety away from shared hotel elevators and busy lobbies while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great choice for families.