Santa Cruz Trips (flight + hotel)

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Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center

Historical Center

7 out of top 10 points of interest in this area

Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.

Find hotels in Historical Center

Top hotels in Santa Cruz

Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4 out of 5
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
The price is P13,524 per night from Apr 13 to Apr 14
P13,524
P14,876 total
Apr 13 - Apr 14
includes taxes & fees
9.2/10 Wonderful! (1,005 reviews)
Staying at this hotel is an adventure in history. To think that we walked the same paths as Christoper Columbus and crew was humbling and gave us a sense of Sevilla’s role in bridging the new world with the old. The hotel is centrally located in the Santa Cruz neighborhood close to all of the must ...

Reviewed on Apr 2, 2026

Las Casas de la Judería, Sevilla Historic City Center
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

5 out of 5
San Fernando 2 Seville Seville
Fully refundableReserve now, pay when you stay
The price is P44,702 per night from Apr 27 to Apr 28
P44,702
P49,172 total
Apr 27 - Apr 28
includes taxes & fees
9.4/10 Exceptional! (1,002 reviews)
Simply amazing property. Amazing service

Reviewed on Apr 8, 2026

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
Hotel Fernando III

Hotel Fernando III

4 out of 5
San Jose 21 Seville Seville
The price is P16,633 per night from May 4 to May 5
P16,633
P18,296 total
May 4 - May 5
includes taxes & fees
9.6/10 Exceptional! (1,490 reviews)
The breakfast was fine

Reviewed on Apr 5, 2026

Hotel Fernando III
See all 436 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Cruz vacation package cost?
Get ready to book, because a trip to Santa Cruz starts from a tempting . When you combine your hotels, flights and car rentals into a package, you'll enjoy the biggest deals.
How do I get a cheap travel package to Santa Cruz?
Just think of all the fun things you could do in Santa Cruz with a pile of extra cash in your pocket. Watch your savings stack up when you combine your travel bookings into a Santa Cruz vacation package. You have plenty of choice when it comes to booking with Expedia too. In fact, you can select from over 550 airlines and 1,000,000 properties around the world. Whether you're enjoying a break with the whole family or traveling with someone special, exploring Santa Cruz is better with a package.
Where should I stay in Santa Cruz?
Most people who visit Santa Cruz put both Seville Cathedral and Alcázar on their must-see lists. Why not choose a hotel close to one of these iconic attractions?
What are the top hotels in Santa Cruz?
Puerta Catedral Holiday Suites and San Isidoro Hostel Sevilla are among the most well-known properties in Santa Cruz. Why not check out the rates and facilities at each and then make up your mind?
How far in advance should I book my Santa Cruz vacation?
Reserving your seat early with Expedia means one less thing to have to worry about. Most carriers advertise prices up to 12 months prior to take off. This is generally the cheapest time to book. If circumstances have left you booking late, great deals to Santa Cruz sometimes emerge in the weeks leading up to departure.
What does an Expedia Santa Cruz travel package include?
Hotels, car rentals and flights — we bring you the very best deals. All you'll have to do is decide on your ideal combination. Once you've made your booking, you can add on the fun stuff like activities and tours. Our travel packages make it easy to craft an awesome Santa Cruz trip.
What should I know before booking a Santa Cruz travel package?
You'll pick up impressive savings when you bundle your flights, hotels and rental cars into a package. Plus, booking everything in one place just makes things easier. So why waste your time or money? Whether you're putting together an upscale romantic escape or a budget family adventure, explore our vacation packages today.
Can I choose my airline with a Santa Cruz Expedia vacation package?
Yes — that's the beauty of an Expedia package. You're in control. We have more than 550 airline partners around the world, so you have loads of choice when organizing your Santa Cruz getaway.
If I'm not able to travel, can I cancel my Santa Cruz vacation package?
Yes, it's possible to cancel your Santa Cruz booking if your travel plans have changed. Whether you'll be charged a fee or not depends on your airline, hotel or car rental company. You may be able to change or cancel for free if you booked in the last 24 hours. Visit our Customer Service Portal to learn more.

Popular places to visit

Giralda Tower

Giralda Tower

This ornate belfry has an interesting past; before being one of the Cathedral's towers, it was a minaret.

Giralda Tower

Things to do

a narrow dirt road leading to a town in Spain

White Villages & Ronda Day Trip from Seville

P5,523
per adult
92% of travellers recommend
White Villages & Ronda Day Trip from Seville
Skip the line combo tour to Alcazar & Cathedral of Seville

Cathedral & Alcázar of Seville Guided Tour Combo

P2,307
per adult
92% of travellers recommend
Cathedral & Alcázar of Seville Guided Tour Combo
Boat Trip "Los Rincones del Guadalquivir"

Boat Trip "Los Rincones del Guadalquivir"

P1,748
per adult
88% of travellers recommend
Boat Trip "Los Rincones del Guadalquivir"
See all activities in Seville
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.