Hotels with Spa in Hannibal, Missouri

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Hannibal Hotels with Spa

Tonight
Dec 31 - Jan 1
Tomorrow
Jan 1 - Jan 2
This weekend
Jan 2 - Jan 4
Next weekend
Jan 9 - Jan 11

Our top choices for Hannibal hotels with a spa

Indoor pool, sun loungers
Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
2.5 star property
Hannibal
7.6 out of 10, Good, (662)
"Below average facility. Needs some upgrades and could use a good cleaning. Staff was helpful."
United States
JACQUI
The price is P4,472
P5,313 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Comfort Inn & Suites - Hannibal
Exterior
Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG
3.0 star property
Quincy
8.8 out of 10, Excellent, (611)
"Overall very nice property. "
United States
Jeffrey
The price is P6,532
P7,445 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Holiday Inn Quincy East by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Hannibal Hotel Reviews

Best Western On The River

Best Western On The River

10/10 Excellent
"Exceptional hotel. Price fair. Staff great. Facilities nice and clean. Only thing is upgrade breakfast. "
Randy 2-night trip
Posted 2 days ago
Best Western On The River

Frequently asked questions

Looking to vacation at a spa hotel in Hannibal?
Forget the stress of everyday life and book yourself a hotel with a spa. Travelers recommend the gourmet restaurants in Hannibal. Enjoy the shopping and riverfront during your vacation. Spa hotels are a great way to break out of your routine and add a layer of luxury to your vacation.
What is the best spa hotel in Hannibal?
Comfort Inn & Suites - Hannibal is a top spa hotel featuring a 24-hour fitness center and an indoor pool. Kick back and relax in the hot tub.
How many spa hotels are there in Hannibal?
Among Expedia's 52 accommodation options in Hannibal, there is 1 spa hotel.
What's there to see and do in Hannibal?
Take in the sights and attractions that Hannibal offers with a visit to Rockcliffe Mansion, Molly Brown Museum and Home, and Jim's Journey: The Huck Finn Freedom Center. If you have a little extra time during your trip, you might want to check out Mark Twain Boyhood Home and Museum and Mark Twain Memorial Lighthouse.
What is a Hannibal spa hotel?
Spa hotels in Hannibal provide lodging and have an on-site spa offering services such as couples massages and beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.

Explore a world of travel with Expedia