Hotels near Greenville Hospital System

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 24 - Dec 25
Tomorrow
Dec 25 - Dec 26
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Greenville Hospital System hotels

Exterior
Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG

Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG

Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG
2.5 star property
1.3 km from Greenville Hospital System
9.4 out of 10, Exceptional, (512)
"Friendly staff and everything was well kept."
United States
Ronny
The price is P7,885
P8,674 total
includes taxes & fees
Dec 25 - Dec 26
Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG
Lobby lounge
Fairfield Inn & Suites by Marriott Greenville Simpsonville

Fairfield Inn & Suites by Marriott Greenville Simpsonville

Fairfield Inn & Suites by Marriott Greenville Simpsonville
2.5 star property
0.9 km from Greenville Hospital System
9.2 out of 10, Wonderful, (667)
"Hotel is good, just not excellent. I would stay here again."
United States
Catherine
The price is P6,988
P7,687 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Fairfield Inn & Suites by Marriott Greenville Simpsonville
Free daily continental breakfast
Hampton Inn Simpsonville

Hampton Inn Simpsonville

Hampton Inn Simpsonville
2.5 star property
0.7 km from Greenville Hospital System
8.8 out of 10, Excellent, (591)
"Everyone was very courteous. Room was very nice. Continental breakfast was excellent every morning."
United States
Karla
The price is P6,748
P7,921 total
includes taxes & fees
Dec 30 - Dec 31
Hampton Inn Simpsonville
Pillowtop beds, desk, laptop workspace, blackout drapes
Comfort Suites Simpsonville - Greenville

Comfort Suites Simpsonville - Greenville

Comfort Suites Simpsonville - Greenville
2.5 star property
1.5 km from Greenville Hospital System
8.2 out of 10, Very Good, (774)
"Great stay! Just wish there would have been a few more healthy breakfast food choices "
United States
Elizabeth
The price is P5,502
P6,052 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Comfort Suites Simpsonville - Greenville
Desk, laptop workspace, iron/ironing board, free WiFi
Quality Inn Simpsonville - Greenville

Quality Inn Simpsonville - Greenville

Quality Inn Simpsonville - Greenville
2.5 star property
0.8 km from Greenville Hospital System
7.4 out of 10, Good, (162)
"Clean and great for the price. Breakfast was sub par though."
United States
Stephen
The price is P3,633
P4,232 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Quality Inn Simpsonville - Greenville
Exterior
Motel 6 Simpsonville, SC - Greenville

Motel 6 Simpsonville, SC - Greenville

Motel 6 Simpsonville, SC - Greenville
2.0 star property
0.9 km from Greenville Hospital System
7.4 out of 10, Good, (353)
"Good son was happy "
United States
Samuel
The price is P4,110
P4,521 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Motel 6 Simpsonville, SC - Greenville
Desk, iron/ironing board, rollaway beds, free WiFi
Days Inn by Wyndham Simpsonville

Days Inn by Wyndham Simpsonville

Days Inn by Wyndham Simpsonville
2.0 star property
0.8 km from Greenville Hospital System
7.2 out of 10, Good, (415)
"Breakfast was limited, rooms were ok, staff okay and nice. Bed had a smoke hole in the sheets. "
United States
Rudes
The price is P4,119
P4,531 total
includes taxes & fees
Dec 25 - Dec 26
Days Inn by Wyndham Simpsonville
Exterior
WoodSpring Suites Greenville Simpsonville

WoodSpring Suites Greenville Simpsonville

WoodSpring Suites Greenville Simpsonville
2.5 star property
2.8 km from Greenville Hospital System
7.0 out of 10, Good, (158)
"Was a good stay no issues "
United States
Kevin
The price is P3,758
P4,134 total
includes taxes & fees
Dec 25 - Dec 26
WoodSpring Suites Greenville Simpsonville
Restaurant
Hotel Hartness

Hotel Hartness

Hotel Hartness
4.0 star property
13.6 km from Greenville Hospital System
9.8 out of 10, Exceptional, (631)
"Beautiful location, friendly staff"
United States
Andrew
The price is P8,906
P11,783 total
includes taxes & fees
Dec 28 - Dec 29
Hotel Hartness
Property amenity
Courtyard by Marriott Greenville Mauldin

Courtyard by Marriott Greenville Mauldin

Courtyard by Marriott Greenville Mauldin
3.0 star property
10 km from Greenville Hospital System
9.2 out of 10, Wonderful, (301)
"Excellent stay "
United States
Shellie
The price is P6,120
P6,732 total
includes taxes & fees
Dec 28 - Dec 29
Courtyard by Marriott Greenville Mauldin
Restaurant
DoubleTree by Hilton Greenville Woodruff Road

DoubleTree by Hilton Greenville Woodruff Road

DoubleTree by Hilton Greenville Woodruff Road
3.0 star property
12.6 km from Greenville Hospital System
9.4 out of 10, Exceptional, (1005)
"Clean modern comfortable convenient location great cookie "
United States
Jimmy
The price is P5,940
P6,534 total
includes taxes & fees
Dec 30 - Dec 31
DoubleTree by Hilton Greenville Woodruff Road
Indoor pool, outdoor pool
Drury Inn & Suites Greenville

Drury Inn & Suites Greenville

Drury Inn & Suites Greenville
3.0 star property
12.8 km from Greenville Hospital System
9.4 out of 10, Exceptional, (1003)
"The staff was really nice, and the room was clean"
United States
Taina
The price is P6,341
P6,976 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Drury Inn & Suites Greenville
Property amenity
Staybridge Suites Greenville I-85 Woodruff Road by IHG

Staybridge Suites Greenville I-85 Woodruff Road by IHG

Staybridge Suites Greenville I-85 Woodruff Road by IHG
3.0 star property
12.3 km from Greenville Hospital System
9.2 out of 10, Wonderful, (317)
"The stay was wonderful. The staff was amazing. Breakfast was an awesome buffet of good food."
United States
Jemmiel
The price is P8,750
P9,625 total
includes taxes & fees
Dec 25 - Dec 26
Staybridge Suites Greenville I-85 Woodruff Road by IHG
Terrace/patio
Tru by Hilton Greenville Woodruff Road

Tru by Hilton Greenville Woodruff Road

Tru by Hilton Greenville Woodruff Road
2.5 star property
12.8 km from Greenville Hospital System
9.2 out of 10, Wonderful, (293)
"Very clean property felt welcoming staff was great"
United States
Christopher
The price is P5,489
P6,594 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Tru by Hilton Greenville Woodruff Road
Property amenity
Residence Inn by Marriott Greenville

Residence Inn by Marriott Greenville

Residence Inn by Marriott Greenville
3.0 star property
12.8 km from Greenville Hospital System
9.2 out of 10, Wonderful, (450)
"Comfortable bed, great location, great water pressure "
United States
Brad
The price is P7,575
P8,333 total
includes taxes & fees
Dec 25 - Dec 26
Residence Inn by Marriott Greenville
Lobby
Comfort Suites Greenville Airport

Comfort Suites Greenville Airport

Comfort Suites Greenville Airport
2.5 star property
15.1 km from Greenville Hospital System
9.4 out of 10, Exceptional, (1006)
"Clean room and very friendly front desk staff"
United States
Lakisha
The price is P5,562
P6,285 total
includes taxes & fees
Dec 30 - Dec 31
Comfort Suites Greenville Airport
Lobby
Hilton Garden Inn Greenville

Hilton Garden Inn Greenville

Hilton Garden Inn Greenville
3.0 star property
12.8 km from Greenville Hospital System
9.0 out of 10, Wonderful, (1000)
"Staff was delightful, especially the front desk and bar staff."
United States
Jason
The price is P5,260
P5,959 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hilton Garden Inn Greenville
Terrace/patio
Homewood Suites by Hilton Greenville

Homewood Suites by Hilton Greenville

Homewood Suites by Hilton Greenville
3.0 star property
12.8 km from Greenville Hospital System
9.0 out of 10, Wonderful, (393)
"Very cleaned and great breakfast selection "
United States
Pedro
The price is P6,707
P7,599 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Homewood Suites by Hilton Greenville
Front of property
Pettigru Place Bed & Breakfast

Pettigru Place Bed & Breakfast

Pettigru Place Bed & Breakfast
3.5 star property
19.3 km from Greenville Hospital System
10.0 out of 10, Exceptional, (125)
"Room was great, clean and comfortable. Staff was outstanding. Great breakfast as well. Super place to stay "
United States
Blake
The price is P11,627
P12,790 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Pettigru Place Bed & Breakfast
Free daily buffet breakfast
Hampton Inn Greenville I-385 - Woodruff Rd.

Hampton Inn Greenville I-385 - Woodruff Rd.

Hampton Inn Greenville I-385 - Woodruff Rd.
3.0 star property
12.1 km from Greenville Hospital System
8.8 out of 10, Excellent, (790)
"Vanessa and Rhonda were excellent hosts and made our stay very comfortable!!"
United States
Victor L
The price is P5,971
P6,765 total
includes taxes & fees
Dec 30 - Dec 31
Hampton Inn Greenville I-385 - Woodruff Rd.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Greenville Hospital System Hotel Reviews

Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG

Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG

10/10 Excellent
"Good"
Trenton 1-night trip
Posted 13 days ago
Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG
Days Inn by Wyndham Simpsonville

Days Inn by Wyndham Simpsonville

10/10 Excellent
"I was a bit skeptical from some of the reviews but it was a lovely stop for us. I felt safe, and the room was clean and good for an overnight trip. We have traveled quite a bit and this was one of the nicer, yet more affordable places we’ve stayed. "
Hannah 1-night trip
Posted 2 months ago
Days Inn by Wyndham Simpsonville

Hotels near other Greenville Hospital System attractions

Fairview Station

You can browse for the perfect souvenirs at Fairview Station during your trip to Simpsonville. Take in the live music and sunrises in the area.
See properties

Piedmont Plaza

You can browse for the perfect souvenirs at Piedmont Plaza during your visit to Simpsonville. Experience the area's live music and theater scene.
See properties

Frequently asked questions

What's the area like around Greenville Hospital System?
Greenville Hospital System is located in Simpsonville. If you're looking for a convenient place to stay, check out the 14 hotels and other accommodations you'll find within a mile.
What's the best hotel to stay close to Greenville Hospital System?
Hampton Inn Simpsonville is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an outdoor pool. It's located just a short 0.4 mi (0.7 km) from Greenville Hospital System. Other good choices close by include Days Inn by Wyndham Simpsonville and Fairfield Inn & Suites by Marriott Greenville Simpsonville.
How many hotels will I be able to find near Greenville Hospital System?
Expedia has 14 hotels and other accommodations within a mile from Greenville Hospital System.
If I need to cancel the hotel reservation for my stay near Greenville Hospital System, will I receive a refund?
Yes, most hotel reservations are refundable if you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of check in. If you have a reservation that's non-refundable, you might still have the option to cancel and receive a refund within 24 hours of booking. Plug in your dates, click on "Search", then use the "fully refundable" filter to review the best deals near Greenville Hospital System.
What can I see and do near Greenville Hospital System?
You can watch performances at Heritage Park, CCNB Amphitheatre, and Younts Center for Performing Arts if you're interested in local theater. Create some family memories at Discovery Island Water Park and Golden Lanes and Golden Skate. A shopping trip to Beck Plaza, Bradford Plaza, or Fairview Station, might be the perfect place to find that souvenir you've been looking for.