Florida Keys Scenic Highway Trips (flight + hotel)

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    Better together
    Save up to P 3,118 when you book a flight and hotel together*
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Top hotels in Florida Keys Scenic Highway

Cheeca Lodge & Spa
Cheeca Lodge & Spa
5 out of 5
81801 Overseas Highway, Mile Marker 82, Marker 82, Islamorada, FL
Fully refundableReserve now, pay when you stay
The price is P9,536 per night from Jul 14 to Jul 15
P9,536
P14,537 total
Jul 14 - Jul 15
includes taxes & fees
9/10 Wonderful! (1,113 reviews)
"Amazing, we will be back as soon as possible. Luxury vacation!"

Reviewed on Jul 4, 2025

Cheeca Lodge & Spa
Chesapeake Beach Resort
Chesapeake Beach Resort
3.5 out of 5
83409 Overseas Hwy, Islamorada, FL
Fully refundableReserve now, pay when you stay
The price is P13,884 per night from Jul 23 to Jul 24
P13,884
P18,793 total
Jul 23 - Jul 24
includes taxes & fees
9/10 Wonderful! (1,479 reviews)
"Super nice staff! Great place to stay!"

Reviewed on Jul 2, 2025

Chesapeake Beach Resort
Hampton Inn Key Largo Manatee Bay
Hampton Inn Key Largo Manatee Bay
2.5 out of 5
102400 Overseas Hwy, Key Largo, FL
Fully refundableReserve now, pay when you stay
The price is P6,848 per night from Aug 4 to Aug 5
P6,848
P7,704 total
Aug 4 - Aug 5
includes taxes & fees
8.6/10 Excellent! (1,002 reviews)
"This is a great property with its own small beach, a tiki bar and a nice pool. Good breakfast included. Spacious rooms with outside seating area. Would recommend a stay here."

Reviewed on Jul 4, 2025

Hampton Inn Key Largo Manatee Bay
See all 8,212 properties in Florida Keys Scenic Highway
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Florida Keys Scenic Highway vacation package cost?
Starting from as low as , a vacation package is your passport to affordable travel. Custom make your Florida Keys Scenic Highway getaway by choosing from our extensive range of airfares, hotels and rental cars.
How do I get a cheap travel package to Florida Keys Scenic Highway?
Just think of all the awesome things you could do in Florida Keys Scenic Highway with a pile of extra cash in your pocket. Watch your savings stack up when you combine your airfare and hotel bookings into a Florida Keys Scenic Highway vacation package. You have loads of choice with Expedia too. In fact, you can pick from over 550 air carriers and 1,000,000 hotels around the globe. Whether you're vacationing with the whole family or going it alone, exploring Florida Keys Scenic Highway is better with a package.
How far in advance should I book my Florida Keys Scenic Highway vacation?
Your best bet is to book early. Air carriers typically release flight tickets up to 12 months ahead of departure, and this is a perfect opportunity to score some of the cheapest prices. Boss just told you to take some vacation time next month? No problem! Expedia are never short of fantastic deals to whisk you away on the getaway of your dreams, at an affordable price.
What does an Expedia Florida Keys Scenic Highway travel package include?
It comes down to what you're looking for. If you're traveling by yourself, you might decide to bundle hotels and flights. Taking the entire family to Florida Keys Scenic Highway? A travel package that includes hotels, flights and rental cars might be a better fit. Expedia gives you the freedom and flexibility to customize your travel package.
What should I know before booking a Florida Keys Scenic Highway travel package?
When you book your flights, hotels and car rentals together, you'll nab great discounts. Whether you're planning a mountain getaway in a cabin or want to stay in a luxurious city hotel, Expedia will make it happen for less.
Can I choose my airline with a Florida Keys Scenic Highway Expedia vacation package?
You can, and with over 550 airlines to choose from throughout the world, you have loads of choice. Search the available options and see which airline fits your budget and needs.
If I'm not able to travel, can I cancel my Florida Keys Scenic Highway vacation package?
We understand --- unexpected stuff happens. If you've booked a Florida Keys Scenic Highway vacation package and have to amend or cancel it, we're here to help. We suggest visiting our Customer Service Portal first for information. But generally speaking, if you've booked your package within 24 hours, you may be able to amend or cancel your itinerary free of charge. If it's been longer than 24 hours, your hotel, airline or car rental company may impose a fee.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.