First Car Rental Car Rentals in Ladys Island

Pick-up and drop-off

Same as pick-up

Pick-up time

Drop-off time

Compare car suppliers to unlock big savings, and package your flight, hotel, and car to save even more.

Heading to Ladys Island? Explore Ladys Island with Expedia's Travel Guides to find the best hotels, vacation packages, car rental deals and more!

Members save 10% or more on over 100,000 hotels worldwide when you’re signed in