Lodging Image

Main Street Fort Pierce Hotels near Fort Pierce

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Oct 9 - Oct 11
Next weekend
Oct 16 - Oct 18

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Main Street Fort Pierce hotels

A hotel lobby with a large reception desk, multiple seating areas, and a patterned carpet.

1. Fairfield Inn & Suites by Marriott Fort Pierce

Fairfield Inn & Suites by Marriott Fort Pierce
3.0 star property
7.7 km from Main Street Fort Pierce
8.8 out of 10, Excellent, (1,001 reviews)
"Plenty of parking and cozy room."
United States
Katherine
The price is P5,816
P6,514 total
includes taxes & fees
Oct 11 - Oct 12
Fairfield Inn & Suites by Marriott Fort Pierce
A hotel lobby with a long dining table, multiple chairs, and a coffee bar with various beverages.

2. Hampton Inn & Suites Ft. Pierce

Hampton Inn & Suites Ft. Pierce
2.5 star property
7.9 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1,001 reviews)
"My weekend stay was a 10/10.I will definitely book my next stay here"
United States
Angela
The price is P6,083
P6,813 total
includes taxes & fees
Nov 1 - Nov 2
Hampton Inn & Suites Ft. Pierce
A modern reception area with a long corridor, a reception desk, and a seating area with tables and chairs.

3. Holiday Inn Express Hotel & Suites Fort Pierce West by IHG

Holiday Inn Express Hotel & Suites Fort Pierce West by IHG
2.5 star property
8.3 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (899 reviews)
"Quiet, fantastic place"
United States
Iosif
The price is P6,278
P7,031 total
includes taxes & fees
Oct 11 - Oct 12
Holiday Inn Express Hotel & Suites Fort Pierce West by IHG
An outdoor seating area with fire feature, stone walls, and a view into the building.

4. Home2 Suites by Hilton Ft. Pierce I-95

Home2 Suites by Hilton Ft. Pierce I-95
3.0 star property
7.8 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (274 reviews)
"Nice little breakfast...very clean and easy check in and check out..."
United States
JERRY
The price is P7,425
P8,316 total
includes taxes & fees
Oct 25 - Oct 26
Home2 Suites by Hilton Ft. Pierce I-95
A pool area with lounge chairs and a hot tub, surrounded by palm trees and a view of the ocean.

5. Hutchinson Island Hotel

Hutchinson Island Hotel
2.5 star property
3.1 km from Main Street Fort Pierce
8.2 out of 10, Very good, (1,376 reviews)
"Great place to stay and enjoy the beach!"
United States
Kathleen
The price is P5,727
P7,580 total
includes taxes & fees
Oct 18 - Oct 19
Hutchinson Island Hotel
A spacious living area with a grey sofa, a blue sofa, and a wooden accent wall with a flat-screen TV.

6. La Quinta Inn & Suites by Wyndham Ft. Pierce

La Quinta Inn & Suites by Wyndham Ft. Pierce
3.0 star property
7.9 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,000 reviews)
"Very clean friendly staff good breakfast"
United States
riad
The price is P5,523
P6,186 total
includes taxes & fees
Nov 8 - Nov 9
La Quinta Inn & Suites by Wyndham Ft. Pierce
A hotel entrance with a welcome sign, a black mat, and two potted plants.

7. At Home Inn

At Home Inn
2.5 star property
8.2 km from Main Street Fort Pierce
8.0 out of 10, Very good, (1,316 reviews)
"Room was clean. Staff was very helpful respectful and breakfast was sufficient"
United States
Ronald
The price is P3,600
P4,033 total
includes taxes & fees
Nov 6 - Nov 7
At Home Inn
A hotel lobby with a reception desk, seating area, and a hallway leading to other rooms.

8. Days Inn & Suites by Wyndham Fort Pierce I-95

Days Inn & Suites by Wyndham Fort Pierce I-95
2.5 star property
7.8 km from Main Street Fort Pierce
7.4 out of 10, Good, (1,000 reviews)
"The staff was excellent"
United States
Carlton
The price is P3,834
P4,294 total
includes taxes & fees
Oct 25 - Oct 26
Days Inn & Suites by Wyndham Fort Pierce I-95
A hotel lobby with a reception desk, a chandelier, a clock, and a sofa.

9. Sleep Inn Fort Pierce I-95

Sleep Inn Fort Pierce I-95
2.5 star property
7.9 km from Main Street Fort Pierce
7.6 out of 10, Good, (916 reviews)
"Staff was very friendly and rooms were clean"
United States
Charity
The price is P4,612
P5,166 total
includes taxes & fees
Oct 9 - Oct 10
Sleep Inn Fort Pierce I-95
A hotel room with a bed, a sofa, and a small table. There are framed pictures on the wall.

10. Comfort Suites Fort Pierce I-95

Comfort Suites Fort Pierce I-95
2.5 star property
7.7 km from Main Street Fort Pierce
7.8 out of 10, Good, (968 reviews)
"Clean rooms, friendly staff"
United States
Marina
The price is P5,291
P5,926 total
includes taxes & fees
Nov 1 - Nov 2
Comfort Suites Fort Pierce I-95
A hotel room with two beds, a television, a ceiling fan, and a view of the beach.

11. The Royal Inn Beach Hotel Hutchinson Island

The Royal Inn Beach Hotel Hutchinson Island
2.5 star property
3.8 km from Main Street Fort Pierce
7.2 out of 10, Good, (1,000 reviews)
"My go-to hotel when I need a place to get away!"
United States
Taylor
The price is P5,932
P7,652 total
includes taxes & fees
Oct 13 - Oct 14
The Royal Inn Beach Hotel Hutchinson Island
A spacious hotel lobby with seating areas, a kitchenette, and large windows.

12. Hampton Inn & Suites Port St. Lucie, West

Hampton Inn & Suites Port St. Lucie, West
2.5 star property
17.4 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (1,003 reviews)
"Our room was very clean and the breakfast was good. Coffee was excellent!"
United States
Hilton
The price is P6,083
P6,813 total
includes taxes & fees
Oct 25 - Oct 26
Hampton Inn & Suites Port St. Lucie, West
A modern living room with a fireplace, a dining area with bar stools, and a large TV mounted on the wall.

13. Hampton Inn & Suites Vero Beach Downtown

Hampton Inn & Suites Vero Beach Downtown
2.5 star property
22.1 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1,000 reviews)
"Easy access and secure parking"
United States
Cameron
The price is P8,183
P9,165 total
includes taxes & fees
Nov 3 - Nov 4
Hampton Inn & Suites Vero Beach Downtown
A Holiday Inn Express & Suites hotel with a modern design, featuring a prominent entrance, well-maintained landscaping, and a clear view of the sky.

14. Holiday Inn Express & Suites Port St. Lucie West by IHG

Holiday Inn Express & Suites Port St. Lucie West by IHG
2.5 star property
17.1 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,000 reviews)
"Great stay"
United States
AEON
The price is P6,905
P7,734 total
includes taxes & fees
Nov 4 - Nov 5
Holiday Inn Express & Suites Port St. Lucie West by IHG
A clear blue swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a gazebo.

15. Best Western Port St. Lucie

Best Western Port St. Lucie
2.5 star property
14 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,000 reviews)
"Good place for a short stay"
United States
BRIAN
The price is P5,649
P6,327 total
includes taxes & fees
Oct 25 - Oct 26
Best Western Port St. Lucie
A multi-story hotel with a modern design, featuring a prominent sign for 'Springhill Suites Marriott'.

16. SpringHill Suites Port St. Lucie

SpringHill Suites Port St. Lucie
3.0 star property
17.2 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,000 reviews)
"Enjoyed my stay!"
United States
Kevin
The price is P6,441
P7,214 total
includes taxes & fees
Oct 15 - Oct 16
SpringHill Suites Port St. Lucie
A spacious lobby with a stone fireplace, comfortable seating, and a bar area.

17. Staybridge Suites Vero Beach by IHG

Staybridge Suites Vero Beach by IHG
3.0 star property
24.1 km from Main Street Fort Pierce
9.6 out of 10, Exceptional, (718 reviews)
"Friendly, helpful staff- comfy beds, safe shuttle service and delicious breakfasts- we ll definitely be back!"
United States
Christine
The price is P7,783
P8,717 total
includes taxes & fees
Oct 18 - Oct 19
Staybridge Suites Vero Beach by IHG
A restaurant interior with a bar area, wooden flooring, and multiple seating arrangements.

18. Days Inn & Suites by Wyndham Fort Pierce Midtown

Days Inn & Suites by Wyndham Fort Pierce Midtown
2.0 star property
4.5 km from Main Street Fort Pierce
7.0 out of 10, Good, (1,000 reviews)
"Good value"
United States
Cynthia
The price is P3,842
P4,303 total
includes taxes & fees
Oct 11 - Oct 12
Days Inn & Suites by Wyndham Fort Pierce Midtown
An outdoor patio area with a fire pit, red and black wicker furniture, and string lights.

19. Residence Inn by Marriott Port St. Lucie

Residence Inn by Marriott Port St. Lucie
3.0 star property
17.8 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (1,000 reviews)
"Great place to stay"
United States
Eduardo
The price is P6,340
P7,101 total
includes taxes & fees
Oct 18 - Oct 19
Residence Inn by Marriott Port St. Lucie
A hotel room with two beds, a small round table, and artwork depicting a beach scene and a zebra.

20. Redfinn Inn

Redfinn Inn
2.5 star property
0.7 km from Main Street Fort Pierce
6.4 out of 10, (418 reviews)
"Great newish renovated property, super clean very quiet excellent staff!"
United States
Robert
The price is P3,814
P4,271 total
includes taxes & fees
Oct 11 - Oct 12
Redfinn Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Main Street Fort Pierce

Find the best Main Street Fort Pierce areas and neighborhoods for the activities you enjoy most.
A coastal area with a narrow waterway, a beach, and residential buildings.

Lakewood Park

While Lakewood Park isn't home to many top sights, McKee Botanical Garden and Avalon State Park are some notable places to visit nearby.

Spanish Lakes Country Club Village

While there might not be top attractions in Spanish Lakes Country Club Village, you can explore the larger area and discover places like Harbor Branch Ocean Discovery Center and McKee Botanical Garden.

A calm lake reflecting trees and a clear sky.

Spanish Lakes Fairways

While Spanish Lakes Fairways might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Lakewood Park Regional Park / Pool and Indrio Road Park / Schoolhouse.

A coastal city with a bay, mangrove islands, and a clear blue sky.

Meadowood

If you're looking for some top things to see and do in Meadowood and surrounding area, you can visit Endless Summer Vineyard & Winery and Al's Family Farms.

A mosaic sign with 'Mainstreet Fort Pierce' written on it.

Panther Woods

If you're looking for some top things to see and do in Panther Woods and surrounding area, you can visit Endless Summer Vineyard & Winery and Al's Family Farms.

Top Main Street Fort Pierce Hotel Reviews

Costa d'Este Beach Resort and Spa

Costa d'Este Beach Resort and Spa

10/10 Excellent
"Q"
Laura 3-night trip
Posted 14 hours ago
Costa d'Este Beach Resort and Spa

Frequently asked questions

What is Main Street Fort Pierce like?
Main Street Fort Pierce is a neighborhood that travelers like for its waterfront, art, and shopping. Be sure to check out Sunrise Theater and Fort Pierce Farmer's Market as part of your Main Street Fort Pierce travel plans.
How many hotels can I expect to find in Main Street Fort Pierce?
Book one of Expedia's 7 hotels and other accommodations in Main Street Fort Pierce and start exploring everything Fort Pierce has to offer.
If I need to cancel my hotel reservation in Main Street Fort Pierce, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then use the filter option "fully refundable" to review the top deals on offer in Main Street Fort Pierce.
What is there to do in this Fort Pierce neighborhood?
Sights like Sunrise Theater and Official Highwaymen Art Gallery can be part of your cultural tour of Main Street Fort Pierce. Fort Pierce Farmer's Market and Fort Pierce City Marina are also a couple of places to visit in the neighborhood. A few places to visit in the area around Main Street Fort Pierce include Manatee Education and Observation Center, House of Seven Gables, and A.E. Backus Museum. Marina at Fort Pierce and Causeway Cove are also worth a visit when you're out sightseeing in Fort Pierce.

Explore a world of travel with Expedia