A large white dome building with a red brick base, surrounded by green trees and a clear blue sky.

Luxury Hotels in Central Missouri, Missouri

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check availability on Central Missouri Luxury Hotels

Tonight
Sep 12 - Sep 13
Tomorrow
Sep 13 - Sep 14
Next weekend
Sep 18 - Sep 20
In two weeks
Sep 25 - Sep 27

Our top choices for Central Missouri luxury hotels

1. DoubleTree by Hilton Hotel Jefferson City

DoubleTree by Hilton Hotel Jefferson City
Jefferson City
P7,919
P9,095 total
includes taxes & fees
Sep 20 - Sep 21
DoubleTree by Hilton Hotel Jefferson City

2. voco The Tiger Hotel Columbia, MO by IHG

voco The Tiger Hotel Columbia, MO by IHG
Columbia
  • Historic charm meets modern luxury in Columbia's heart with pillowtop beds, 24-hour service, and immaculate spaces.
P10,096
P12,485 total
includes taxes & fees
Sep 20 - Sep 21
voco The Tiger Hotel Columbia, MO by IHG

3. Camden on the Lake Resort & Spa

Camden on the Lake Resort & Spa
Lake Ozark
  • Lakeside spa resort offers luxury treatments and poolside cocktails for a serene escape.
P5,413
P8,234 total
includes taxes & fees
Oct 5 - Oct 6
Camden on the Lake Resort & Spa

4. Lodge Of Four Seasons Golf Resort, Marina & Spa

Lodge Of Four Seasons Golf Resort, Marina & Spa
Lake Ozark
  • Lakeside retreat features spa treatments, 36 holes of championship golf, and Japanese gardens.
P5,224
P7,144 total
includes taxes & fees
Oct 11 - Oct 12
Lodge Of Four Seasons Golf Resort, Marina & Spa

5. Drury Plaza Hotel Columbia East

Drury Plaza Hotel Columbia East
Columbia
P5,894
P6,659 total
includes taxes & fees
Sep 27 - Sep 28
Drury Plaza Hotel Columbia East

6. The Broadway Columbia - a DoubleTree by Hilton

The Broadway Columbia - a DoubleTree by Hilton
Columbia
P9,513
P10,795 total
includes taxes & fees
Oct 4 - Oct 5
The Broadway Columbia - a DoubleTree by Hilton

7. Hermann Hill

Hermann Hill
Hermann
P22,058
P25,361 total
includes taxes & fees
Sep 16 - Sep 17
Hermann Hill

8. Walnut Waters Bed & Breakfast

Walnut Waters Bed & Breakfast
Lone Jack
P19,995
P21,490 total
includes taxes & fees
Sep 27 - Sep 28
Walnut Waters Bed & Breakfast

9. Up Up and Away Lodging

Up Up and Away Lodging
Hermann
P16,595
P17,773 total
includes taxes & fees
Sep 14 - Sep 15
Up Up and Away Lodging

10. The Mercantile on the Katy Trail

The Mercantile on the Katy Trail
Hermann
  • Newly renovated Victorian retreat offers golf, garden sanctuary, and luxury suites on the Katy Trail.
P11,994
P12,891 total
includes taxes & fees
Sep 15 - Sep 16
The Mercantile on the Katy Trail
View all properties

Top Central Missouri Hotel Reviews

Baymont by Wyndham Columbia, MO

Baymont by Wyndham Columbia, MO

10/10 Excellent
"a lot nicer than I thought it would be. Good beds"
Jackie 1-night trip
Posted 1 hour ago
Baymont by Wyndham Columbia, MO
Capitol Plaza Hotel Jefferson City

Capitol Plaza Hotel Jefferson City

8/10 Good
"Our tv didn’t work and parking was $10, which is weird since we’re staying at their hotel. But room was clean and beds were very comfortable. I would stay again."
Donna 2-night trip
Posted 7 hours ago
Capitol Plaza Hotel Jefferson City
Margaritaville Lake Resort Lake of the Ozarks

Margaritaville Lake Resort Lake of the Ozarks

10/10 Excellent
"Property was clean staff was very helpful. Great restaurants and pools!"
Tony 2-night trip
Posted 1 day ago
Margaritaville Lake Resort Lake of the Ozarks

Explore a world of travel with Expedia