Expedia is your one-stop shop for organizing every aspect of your getaway. Find the ideal car rental to tour around Piazza del Duomo, then add on your flights and hotel to land the best possible price. Many car rental outlets offer free cancellation, so there's no need to stress if your plans change. Make sure you join Expedia Rewards to earn points on your car rental and other bookings. They'll help you save on your next big adventure, whether that's a few days in the city or a transcontinental road trip!