Cairo Hotels

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Tonight
Nov 22 - Nov 23
Tomorrow
Nov 23 - Nov 24
Next weekend
Nov 28 - Nov 30
In two weeks
Dec 5 - Dec 7

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Top 10 trending Cairo hotels

Lobby
Quality Inn Cairo I-57

Quality Inn Cairo I-57

2.5 star property
Cairo
6.6 out of 10, (272)
"Break fast was excellent "
United States
Uma
The price is P4,021
P4,462 total
includes taxes & fees
Nov 28 - Nov 29
Quality Inn Cairo I-57
Front of property - evening/night
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
Charleston
6.6 out of 10, (609)
"Staff was great! Room was nice. "
United States
Lana
The price is P3,162
P3,509 total
includes taxes & fees
Nov 23 - Nov 24
Super 8 by Wyndham Charleston/Sikeston East MO
Desk, laptop workspace, blackout drapes, iron/ironing board
Quality Inn Charleston - Sikeston

Quality Inn Charleston - Sikeston

2.5 star property
Charleston
6.8 out of 10, (406)
"The staff was very friendly and accommodating "
United States
Arturo
The price is P3,866
P4,290 total
includes taxes & fees
Dec 1 - Dec 2
Quality Inn Charleston - Sikeston
Desk, iron/ironing board, free WiFi, alarm clocks
Eagle Inn Charleston

Eagle Inn Charleston

2.0 star property
Charleston
6.8 out of 10, (102)
"Middle of nowhere hotel was ok"
United States
David
The price is P3,559
P3,950 total
includes taxes & fees
Nov 23 - Nov 24
Eagle Inn Charleston
Interior
Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah

3.0 star property
Cunningham
The price is P7,885
P16,159 total
includes taxes & fees
Dec 22 - Dec 23
Quiet Country Stay: Modern Home Near Paducah
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Cairo attractions

Fort Defiance State Park

You can take time to visit Fort Defiance State Park during your travels to Cairo. Stroll along the riverfront or visit the churches while you're in the area.
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Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artifacts from this once-thriving river port town.

See all hotels in Cairo
Cairo Ohio River Bridge traversing over the Ohio River at sunset

Top Cairo Hotel Reviews

La Center Motel

La Center Motel

10/10 Excellent
"The place was very clean"
Victoria 1-night trip
Posted 3 months ago
La Center Motel
Upscale & Quiet Paducah Retreat on 15 Acres!

Upscale & Quiet Paducah Retreat on 15 Acres!

10/10 Excellent
"This was our first time in Kentucky visiting family, had an awesome time. Being able to stay in a cabin was great, have our own space to enjoy the family without the hotel feel. "
Victor 5-night trip
Posted 8 months ago
Upscale & Quiet Paducah Retreat on 15 Acres!

More cheap stays in Cairo

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO
The price is P3,162 per night from Nov 23 to Nov 24
P3,162
P3,509 total
Nov 23 - Nov 24
includes taxes & fees
6.6/10 (607 reviews)

Frequently asked questions

Where is the best place for a stay in Cairo?
Based on our traveler data, Quality Inn Cairo I-57 is one of the top choices for your stay. This hotel offers free breakfast and free parking. Other good choices for your trip to the area are Super 8 by Wyndham Charleston/Sikeston East MO and Quality Inn Charleston - Sikeston. See all available top hotels, or vacation rentals in Cairo.
If I need to cancel my hotel reservation in Cairo, will I receive a refund?
Yes! Most hotel room reservations are refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cairo.
What is staying in Cairo like?
Visitors can enjoy all that Cairo has to offer including the restaurants, entertainment choices, and riverfront. This city also attracts tourists with its small-town vibe. There are 25 hotels and other accommodations in the surrounding area. Find out more about Cairo.
What should I see while I'm in Cairo?
The picturesque setting of Mississippi River and Ohio River Valley exemplify the area's natural beauty. Additionally, you might want to add Fort Defiance State Park to your itinerary. Check out what more to see and do in Expedia's Cairo guide.
What's the seasonal weather like in Cairo?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.

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