Cairo Hotels

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Aug 2 - Aug 3
Tomorrow
Aug 3 - Aug 4
Next weekend
Aug 8 - Aug 10
In two weeks
Aug 15 - Aug 17

Filter by

Guest rating
Guest rating
Star rating

Top 10 trending Cairo hotels

La Center Motel
Relax in this inviting room with two single beds, a desk, and a bathroom featuring a sink and mirror.

La Center Motel

2.0 star property
7.8 out of 10, Good, (14)
"Front desk staff was amazing. Room was comfy and quiet! Clean! Husband and I needed a place to crash on our long ride home and this motel did not disappoint!"
La Center Motel
Quality Inn Cairo I-57
Relax in the stylish lobby, featuring a reception desk, comfortable seating areas, and beautiful artwork.

Quality Inn Cairo I-57

2.5 star property
6.6 out of 10, (263)
"The hotel is in need of some serious upkeep and cleaning. It is in fairly poor condition, but it the only hotel in town."
The price is P4,238
P4,703 total
includes taxes & fees
Aug 12 - Aug 13
Quality Inn Cairo I-57
Super 8 by Wyndham Charleston/Sikeston East MO
Welcome to Simmons Hotel, where guests can enjoy a convenient covered entrance and parking.

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
6.6 out of 10, (577)
"Located very close to the expanse of corn fields, quiet, clean rooms, everything is neat, the bathroom is also very clean. Friendly receptionist."
The price is P3,510
P3,895 total
includes taxes & fees
Aug 10 - Aug 11
Super 8 by Wyndham Charleston/Sikeston East MO
Quality Inn Charleston - Sikeston
Two single beds with matching headboards, a wooden dresser, and a desk with a chair.

Quality Inn Charleston - Sikeston

2.5 star property
6.8 out of 10, (396)
"I consistently choose to stay there due to positive past encounters."
The price is P3,963
P4,398 total
includes taxes & fees
Aug 12 - Aug 13
Quality Inn Charleston - Sikeston
Eagle Inn Charleston
Two single beds with white linens and dark headboards, a green accent wall, and a window with a brown curtain.

Eagle Inn Charleston

2.0 star property
6.8 out of 10, (100)
"Comfortable bed, easy access to room"
The price is P3,710
P4,118 total
includes taxes & fees
Sep 1 - Sep 2
Eagle Inn Charleston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about Cairo

Escape to quaint Cairo! Enjoy its ruins, history, and entertainment.

See all hotels in Cairo

Top Cairo Hotel Reviews

La Center Motel

La Center Motel

10/10 Excellent
"Front desk staff was amazing. Room was comfy and quiet! Clean! Husband and I needed a place to crash on our long ride home and this motel did not disappoint!"
ChelseaMae 1-night trip
Posted 1 month ago
La Center Motel
Upscale & Quiet Paducah Retreat on 15 Acres!

Upscale & Quiet Paducah Retreat on 15 Acres!

10/10 Excellent
"This was our first time in Kentucky visiting family, had an awesome time. Being able to stay in a cabin was great, have our own space to enjoy the family without the hotel feel. "
Victor 5-night trip
Posted 4 months ago
Upscale & Quiet Paducah Retreat on 15 Acres!

Frequently asked questions

Where is the best place for a stay in Cairo?

Based on our traveler data, Quality Inn Cairo I-57 is one of the top choices for your stay. This hotel offers free breakfast and free parking. Other good choices for your trip to the area are Super 8 by Wyndham Charleston/Sikeston East MO and Quality Inn Charleston - Sikeston. See all available top hotels, or vacation rentals in Cairo.

If I need to cancel my hotel reservation in Cairo, will I receive a refund?

Yes! Most hotel room reservations are refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cairo.

Where can I learn more about changing or cancelling my trip to Cairo?

For more information about updating your trip to Cairo or cancelling it, head over to our customer service page.

Where is the best hotel to stay close to Fort Defiance?

Quality Inn Cairo I-57 is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 4.9 mi (7.8 km) from Fort Defiance. Other good options around the area include Victorian Splendor in So. Illinois: wallmanor.com and Eagle Inn Charleston.

What are some hotels with pools in Cairo?

Quality Inn Cairo I-57 is a top hotel with a seasonal outdoor pool, free full breakfast, and free WiFi.

What's the best hotel for staying near Barkley Regional Airport (PAH)?

Drury Inn & Suites Paducah is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and an indoor pool. It's located 4.7 mi (7.6 km) from Barkley Regional Airport. Other choices close to the airport include La Quinta Inn & Suites by Wyndham Paducah and Baymont by Wyndham Paducah.

What is staying in Cairo like?

Visitors can enjoy all that Cairo has to offer including the restaurants, entertainment choices, and riverfront. This city also attracts tourists with its small-town vibe. There are 24 hotels and other accommodations in the surrounding area. Find out more about Cairo.

What should I see while I'm in Cairo?

A couple of favorite places to visit are Mississippi River and Fort Defiance State Park. You'll also find Mound City National Cemetery and Columbus-Belmont State Park in the area. Check out what more to see and do in Expedia's Cairo guide.

What's the seasonal weather like in Cairo?

The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.